Sensitization potential and potency of terpene hydroperoxides in the cocultured activation test method

Hennen, Jennifer; Sousa, Marta Silva E; Sahli, Fatma; Lichter, Jutta; Lepoittevin, Jean‐Pierre; Giménez‐Arnau, Elena; Blömeke, Brunhilde

doi:10.1111/cod.13286

Cited by 9 publications

(13 citation statements)

References 36 publications

(77 reference statements)

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“…Probably the "hottest" topic in the field of fragrance contact allergy is the role of terpene hydroperoxides as autoxidation products of terpenes used as fragrances, and specifically, of limonene and linalool hydroperoxides (Lim-OOHs and Lin-OOHs, respectively). These have been demonstrated to be important contact allergens when patch tested (in consecutive patients) [66][67][68], in accordance with experimental results [69]. However, hitherto there is still uncertainty regarding the quantity and eliciting role of hydroperoxides present in cosmetic products patients have actually been using.…”

Section: Fragrancessupporting

confidence: 69%

Contact Allergy—Emerging Allergens and Public Health Impact

Uter

Werfel

Lepoittevin

et al. 2020

IJERPH

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Contact allergy (sensitisation) and allergic contact dermatitis (ACD) resulting from it have a considerable public health impact. For the present review, all pertinent articles were systematically searched via Medline and Web of Science™; additionally, all available issues of the journals “Contact Dermatitis” and “Dermatitis” were manually searched, covering the years 2018–2019, thereby extending and re-focusing a previous similar review. New allergens, or previously described allergens found in a new exposure context or of other current importance, are described in sections according to substance classes, e.g., metals, preservatives, fragrances. As a common finding in many investigations, a lack of information on product composition has been noted, for instance, regarding a newly described allergen in canvas shoes (dimethylthiocarbamylbenzothiazole sulfide) and, most notably, absence of co-operation from manufacturers of glucose-monitoring devices and insulin pumps, respectively. These latter devices have been shown to cause severe ACD in a considerable number of diabetic patients caused by the liberation of isobornyl acrylate and N,N’-dimethylacrylamide, respectively, as demonstrated by an international collaboration between dermatologists and chemists. Improved and complete ingredient labelling for all types of products, and not just as we have with cosmetics at present (apart from full listing of fragrance substances) in Europe, must be put on the legislative agenda.

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Section: Fragrancessupporting

confidence: 69%

Contact Allergy—Emerging Allergens and Public Health Impact

Uter

Werfel

Lepoittevin

et al. 2020

IJERPH

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“…Details on synthesized hydroperoxides are given in Appendix S2 (see Supporting Information). Concentrations for R‐OOHs (300 µmol L −1 ) and 2,4‐dinitrochlorobenzene (DNCB) (20 µmol L −1 ) are based on previous experiments 22 and allowed for direct comparison of the results.…”

Section: Methodsmentioning

confidence: 99%

Skin sensitization to fragrance hydroperoxides: interplay between dendritic cells, keratinocytes and free radicals

et al. 2020

Self Cite

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“…Furthermore, the in vitro COCAT method was also shown to be able to identify the potency of skin sensitizers (Hennen and Blömeke, 2017a) and rank structurally related hair dye molecules Blömeke, 2017b, 2018). Further, coculture of THP-1 cells with reconstructed human epidermis (RHE) takes penetration of the compounds into consideration (Schellenberger et al, 2019;Hennen et al, 2019).…”

Section: The Cocatmentioning

confidence: 99%

The HaCaT/THP-1 Cocultured Activation Test (COCAT) for skin sensitization: a study of intra-lab reproducibility and predictivity

Eskes¹,

Hennen

Schellenberger

et al. 2019

ALTEX

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Regulation requires that skin sensitization hazard and potency of chemicals is assessed by a combination of in vitro and in chemico studies and that in vivo testing is conducted only as a last resort (EU, 2016).Given the complexity of the biological mechanisms underlying skin sensitization, it is generally recognized that a combination of mechanistically-based test methods is needed for both skin sensitization hazard assessment and potency prediction (Jowsey et al., 2006;OECD, 2014). Considerable progress has been made in the last decade regarding the development, validation, and adoption of alternative methods for skin sensitization hazard identification. In particular, a number of OECD Test Guidelines (TG) have been adopted that address the three major key events of the adverse outcome pathway (AOP) leading to skin sensitization. These are i) the covalent binding of electrophilic substances to nucleophilic centers in skin proteins as the molecular initiating event or first key event (OECD, 2019),

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Sensitization potential and potency of terpene hydroperoxides in the cocultured activation test method

Abstract: Background: Positive patch test reactions to mixtures of oxidized terpenes con-

Cited by 9 publications

References 36 publications

Contact Allergy—Emerging Allergens and Public Health Impact

Contact Allergy—Emerging Allergens and Public Health Impact

Skin sensitization to fragrance hydroperoxides: interplay between dendritic cells, keratinocytes and free radicals

The HaCaT/THP-1 Cocultured Activation Test (COCAT) for skin sensitization: a study of intra-lab reproducibility and predictivity

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