Sensitization of the Mouse to Bradykinin.

Regulation of bradykinin receptor level by cholera toxin, pertussis toxin and forskolin in cultured human fibroblasts

“…The initial report of a toxin-induced enhancement of bradykinin action was made by Malkiel & Hargis (1967), who described the increased lethality of an injection of bradykinin into mice previously treated with pertussis toxin. In 1988, Moss et al demonstrated that the stimulation of prostaglandin production by bradykinin was greater in cultured fibroblasts that were pretreated with various agents, including cholera and pertussis toxin, than in untreated cells.…”

<i>Bordetella pertussis</i> as a Beta-Adrenergic Blocking Agent

“…It has been shown that both B. pertussis and /7-adrenergic blocking agents, such as propranolol, can attenuate or abolish several of the effects normally elicit ed by epinephrine including its hyperglycemic, free fatty acid-mobilizing, as well as its positive chronotropic effects [8,11,25]. Similarly, both B. pertussis and propranolol enhance the sensitivity of mice to pharmacolog ical agents such as histamine, serotonin, and bradykinin [17,19,22], Our results indicate that the sensitizing actions shared by HSF and proprano lol in mice can be extended to include a variety of additional stressful stimuli, including experimental immune hemolytic anemia, cold stress, and endotoxin.…”

“…Although several possible mechanisms of HSF action have been explored in detail [4,8,19], accumulated evidence suggests that it may exert its sensitizing effects by inducing a blockade of the /9-adrenergic receptors of the autonomic nervous system. It has been shown that yS-adrenergic blocking agents, such as propranolol, can be successfully substituted for HSF in altering physiological reactivity, as well as in en hancing the susceptibility of mice to pharmacological agents, such as his tamine, serotonin and bradykinin [17,19,22], We considered it of inter est to determine whether both HSF and propranolol could similarly heighten the sensitivity of mice to other forms of stressful stimuli. In this paper we report the effect of extracted HSF, and propranolol, on the sus ceptibility of mice to experimental immune hemolytic anemia, hypo thermic stress, and bacterial endotoxin.…”

Comparison of vaccination of mice and rats with Haemophilus influenzae and bordetella pertussis as models of atopy

“…After B. pertussis vaccination of mice, enhanced sensitivities are also described for histamine, methacholine, adrenaline, bradykinin and serotonin, dependent on the mouse strain used (Dietrich, Komarek, Pericin, 1971 ;Fishel & Szentivanyi, 1963;Malkiel & Hargis, 1967;Townley et al, 1967). The specificity of B. pertussis in this respect has not been extensively investigated, therefore, the effect of H. infhrenzue vaccination was tested on the sensitivity to several drugs.…”