Sensitivity to Sulfadiazine Resembling Acute Disseminated Lupus Erythematosus

Hoffman, Byron J.

doi:10.1001/archderm.1945.01510210032007

Cited by 117 publications

(47 citation statements)

References 3 publications

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“…Often the diagnosis is late, with the average duration of onset of lesions up to the diagnosis of 13.5 years. The process may have a chronic, localized or benign course; however, patients need a follow up and to be monitored for progression to systemic amyloidosis and plasmocytic dyscrasias, which occurs in about 7% to 50% of patients [12] [14] [16]. The patient in the present report claimed that his lesions had started about 3 years before which shows late diagnosis and its chronic course, which reveals the importance of early diagnosis and follow-up.…”

Section: Discussionmentioning

confidence: 71%

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Nodular Amyloidosis Overlapping and Polymyositis in a Patient with Skin Manifestations Lupus Fax: Case Report

Filho¹,

Couto²,

Soares³

et al. 2017

JBM

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Amyloidosis is the result of fibrous and insoluble amyloid protein deposition in extracellular spaces of tissues and organs, including the skin. Through the analysis of medical records, clinical condition and laboratory tests, this article proposes a rare case report of an adult patient with symptoms and diagnosis of polymyositis, histopathology of nodular amyloidosis with skin lesions suggestive of lupus. The patient is still being followed at the dermatology clinic of Valença Medical School, in order to improve the prognosis and prevent the progression of existing symptoms.

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Section: Discussionmentioning

confidence: 71%

“…The pathology also occurs in both sexes, with a mean age at diagnosis of 60.8 years [12] [14] [16]. Often the diagnosis is late, with the average duration of onset of lesions up to the diagnosis of 13.5 years.…”

Section: Discussionmentioning

confidence: 99%

Nodular Amyloidosis Overlapping and Polymyositis in a Patient with Skin Manifestations Lupus Fax: Case Report

Filho¹,

Couto²,

Soares³

et al. 2017

JBM

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“…Over the following 30 years, disease studies registered the actuality of wire-loop lesions in individuals with glomerulonephritis and nonbacterial verrucous endocarditis (Libman-Sacks Lupus 20 disease), discovered and named by Emanuel Libman and Benjamin Sacks [26,27]; it was these reviews at the autopsy table that led to the fabrication of collagen disease, which was suggested by Kemperer and colleagues in the 1940s [28]. Major advancements in the field of lupus occurred during 1920-1930 by the pathologists working at Mt.…”

Section: Lupusmentioning

confidence: 99%

Introduction and Physiology of Lupus

Zaman¹

2017

Lupus

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“…O primeiro relato de LES induzido pelo uso de um medicamento, a sulfadiazina, foi feito em 1945 (2) . A introdução de novas drogas na prática clínica tem sido acompanhada pelo aumento no número de medicamentos implicados como desencadeantes dessa condição patológica (3) .…”

Section: Introductionunclassified

“…, Gustavo Pavlik Haddad (2) , Rodrigo Aires Corrêa Lima (3) , Jozélio Freire de Carvalho (4) , Maria Imaculada Muniz-Junqueira (5) , Leopoldo Luiz dos Santos Neto (6) , Francisco Aires Corrêa Lima (7) RESUMO O lúpus induzido por drogas (LID) é descrito como o desenvolvimento de sintomas semelhantes ao do lúpus eritematoso sistêmico idiopático, temporalmente relacionado à exposição a drogas, havendo, comumente, a resolução do quadro com a suspensão do medicamento desencadeante. A associação mais clássica é feita com a procainamida e a hidralazina.…”

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Lúpus induzido por drogas: da imunologia básica à aplicada

Mota

Haddad

Lima

et al. 2007

Rev. Bras. Reumatol.

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RESUMOO lúpus induzido por drogas (LID) é descrito como o desenvolvimento de sintomas semelhantes ao do lúpus eritematoso sistêmico idiopático, temporalmente relacionado à exposição a drogas, havendo, comumente, a resolução do quadro com a suspensão do medicamento desencadeante. A associação mais clássica é feita com a procainamida e a hidralazina. Recentemente, com a introdução de novas drogas na prática clínica, tem sido relatado um aumento no número de medicamentos implicados como causadores da doença, e a lista atual inclui quase uma centena de drogas relacionadas à ocorrência de LID. Embora descrito há mais de 60 anos, o mecanismo imunológico básico do LID ainda não está totalmente compreendido. Há várias hipóteses para o processo de indução de auto-imunidade pelas drogas, e o fenômeno geralmente é interpretado como uma inapropriada ativação do sistema imunitário. Entre as diversas teorias propostas, as mais aceitas são: a inibição da metilação do ácido desoxirribonucléico (DNA) por algumas drogas, o que permitiria a ativação das células T; a oxidação de certas substâncias pelos monócitos, gerando metabólitos ativos que ocasionariam ativação das células apresentadoras de antígenos e/ou a interferência dos metabólitos de determinadas drogas com a tolerância do sistema imune. Novos estudos são necessários para a melhor compreensão da imunopatogenia do LID, objetivando desenvolver tratamentos específicos com base no melhor conhecimento dos mecanismos patogênicos.Palavras-chave: lúpus induzido por drogas, imunologia, lúpus eritematoso sistêmico, droga, auto-imunidade. ABSTRACTDrug-induced lupus (DIL) has been described as the development of idiopathic systemic lupus erythematous-like symptoms, temporarily associated to the exposition to drugs, and as a rule, the condition is improved with the suspension of the triggering medication. The most classical association is with procainamide and hydralazine. Recently, with the introduction of new drugs in the clinical practice, an increase on the number of medications associated with the occurence of the disease has been reported, and the current list includes almost one hundred drugs associated to the occurrence of DIL. The basic DIL immunologic mechanism, although described for more than 60 years, is not yet fully understood. There are several hypotheses for the druginduced autoimmunity process, and the phenomenon is generally interpreted as an inappropriate activation of the immune system. Among the several theories proposed, the most accepted ones are: the inhibition of the DNA methylation by some drugs, what would allow the activation of T-cells; the oxidation of some substances by monocytes, what would generate active metabolites that in turn would lead to the activation of antigen-presenting cells and/or the interference of the metabolites of some drugs with the immune system tolerance. Further studies should be conducted in order to elucidate the DIL immunopathogeny with the objective of developing specific treatments based on the better knowledge on the pathog...

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Sensitivity to Sulfadiazine Resembling Acute Disseminated Lupus Erythematosus

Cited by 117 publications

References 3 publications

Nodular Amyloidosis Overlapping and Polymyositis in a Patient with Skin Manifestations Lupus Fax: Case Report

Nodular Amyloidosis Overlapping and Polymyositis in a Patient with Skin Manifestations Lupus Fax: Case Report

Introduction and Physiology of Lupus

Lúpus induzido por drogas: da imunologia básica à aplicada

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