Sensitivity to Rubber Chemicals and Latex Among Hemodialysis Patients

Abstract

Sir, and a positive CAP to latex (6.22 kU/l). By history, the latex allergy was induced by hemodialysis. She did not manifest Patients undergoing chronic hemodialysis can, although rarely, develop hypersensitivity reactions to substances used in dialysis dermatitis or pruritus, nor a history of atopy. None of the other subjects had latex sensitivity based on skin tests or CAP. equipment (1, 2). The aim of our study was to evaluate the frequency of latex and rubber chemical hypersensitivity in Eighty-three patients (53.9%) accepted to undergo the patch test. A history of atopic disease was reported by 6 subjects patients undergoing long-term hemodialysis. (7.2%), pruritus by 35 (42.2%) and dermatitis by 22 (26.5%). Sixteen patients (19.3%), exhibited positive patch tests to PATIENTS AND METHODS rubber antigens (Table I). For 9 of them, the rubber allergy We enrolled 154 consecutive hemodialysis patients (66 women and 88 was considered clinically relevant, as these patients had previmen). The median time of dialysis was 53Ô 44 months, with a range ously had episodes of allergic contact dermatitis following of 1± 205 months. Skin-prick tests were performed with a standardized exposure to the rubber allergens. However, it was not possible commercial extract of non-ammoniated latex (StallergeÁ nes, Paris, to assess whether the sensitivity to the rubber chemicals was France) and with glove extracts prepared as previously reported (3). Brie¯y, twenty 1 cm2 (400 mg total weight) freshly cut glove pieces

Hypersensitive Reactions During Hemodialysis Treatment: What Do We Need to Know?

“…Other allergens -Hypersensitivity reactions to dialysis membranes may not depend on the main membrane component but to any component of dialysis machinery including acetate [79], latex [80,81], topical bovine thrombin [82], nickel [83], povidone-iodine [28], polyvinylpyrrolidone [47], lidocaine [28], bisphenol A [84],…”