Sensitivity to Gentian Violet (Methylrosaniline)

Two-Dimensional Cellular and Three-Dimensional Bio-Printed Skin Models to Screen Topical-Use Compounds for Irritation Potential

“…Methyl violet has been reported as a carcinogen and eye irritant in mice (Littlefield et al, 1985), as well as a few reports of contact sensitization to this dye (Bielicky and Novák, 1969;Bajaj and Gupta, 1986). The first report of methylrosaniline-caused allergy was as early as 1940 (Goldstein, 1940). At that time, 3% methylrosaniline solution was applied in an intertriginous space; meaning that the observed response could be due to toxicity or irritancy rather than a physical allergy.…”

Compound allergy to a skin marker for patch testing: a chromatographic analysis

“…Reported cases of allergic contact dermatitis from gentian violet, with positive patch or intradermal tests, have generally been in patients with "stasis" eczema or ulceration of the leg (7)(8)(9), although a patient treated for pruritus vulvae has also been reported (10). I reported patient with leg ulceration was additionally sensitive to several other medicaments (9).…”

Gentian violet: Revisited

“…There are reports of irritant contact dermatitis with gentian violet 3% preparation. 36,37 The predisposing factors mentioned in these reports were application on intertriginous area and prolonged contact. Pasricha et al 38 and Bajaj et al 39 found contact sensitivity to gentian violet.…”