Sensitivity-to-change and validity of semi-automatic joint space width measurements in hand osteoarthritis: a follow-up study

Abstract

Assessment of progression in hand OA defined by JSW measurements is possible, but performs less well than progression defined by JSN scoring. Therefore, the value of JSW measurements in hand OA clinical trials remains questionable.

Radiographic temporal subtraction analysis can detect finger joint space narrowing progression in rheumatoid arthritis with clinical low disease activity

“…studied the validity of semi-automatic JSW measurements using US findings and reported that progression in both semi-automatic JSW and conventional scoring methods showed associations with inflammatory US features at baseline (31). In the current study, we also found association between US findings and progression of semi-quantitative JSN scoring and semi-automated JSW measurements.…”

Clinimetrics of ultrasound pathologies in osteoarthritis: systematic literature review and meta-analysis

“…For semi-quantitative score, the kappa values varied from slight in cartilage thickness 51 to substantial in osteophyte and synovitis 5,12 . For quantitative score, ICC was excellent in synovial hypertrophy 54 .…”

“…There were four inter-rater reliability studies for binary scores 50e53 , three for semi-quantitative scores 5,12,51 and one for quantitative scores 54 .The binary scoring system provided the kappa ranging from slight in cartilage thickness 51 to excellent in synovitis, effusion and osteophyte 52 . For semi-quantitative score, the kappa values varied from slight in cartilage thickness 51 to substantial in osteophyte and synovitis 5,12 .…”

Guidelines for the conduct of pharmacological clinical trials in hand osteoarthritis: Consensus of a Working Group of the European Society on Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO)

“…The primary endpoint may be assessed either as radiographic change using semi-quantitative scoring systems such as the KL grading scale, which is a global OA scale, or the OARSI atlas, which assesses individual OA features [49]. Alternatively, change in quantitative joint space width (JSW) or progression quantified as joint space narrowing (JSN) and measured by conventional X-ray can be used [50]. However, JSW assessment has not been fully validated and the optimal analysis of JSW measurement to maximise sensitivity to change is to be determined.…”