Sensitivity to Bee Venom Antigen Phospholipase A2: Association With Specific HLA Class I and Class II Alleles and Haplotypes in Beekeepers and Allergic Patients

Sánchez-Velasco, Pablo; Antón, E.; Muñoz, D.; Martínez-Quesada, Jorge; Alegrı́a, Carlos Ruı́z de; López-Hoyos, Marcos; García-Martín, Alfredo; Jiménez, I Fernández; Alonso, S.; Duque, S.; Suárez, Alicia; Jerez, J.; Leyva-Cobián, Francisco

doi:10.1016/j.humimm.2005.04.001

Cited by 4 publications

(4 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Higher frequencies of DRB1*0101 and DQB1*0501 alleles have also been shown in the Caucasian subjects sensitized to bee venom allergen phospholipase A 2 (Sanchez-Velasco et al 2005) and cockroach (Donfack et al 2000) than in non-sensitized controls. An increased risk for cockroach allergy is especially interesting since the cockroach allergen Bla g 4 is also a lipocalin protein (Arruda et al 1995).…”

Section: Discussionmentioning

confidence: 81%

“…This study affiliates farming to the occupations in which genetic factors have been shown to associate with allergic sensitization. Previously, HLA associations have been shown for example in health care workers (hevein) (Rihs et al 2002), sawmill workers (western red cedar) (Horne et al 2000), laboratory animal workers (rat urine) (Jeal et al 2003), and bee-keepers (insect venom) (Sanchez-Velasco et al 2005). Knowing the HLA associations of common sensitizers can facilitate the diagnosis of occupational disorders.…”

Section: Discussionmentioning

confidence: 99%

“…Sensitization, for example, to Art v 1 of mugwort (Jahn-Schmid et al 2002;Torio et al 2003) or phospholipase A 2 (PLA 2 ) of bee venom (Sanchez-Velasco et al 2005) have been associated with HLA-DRB1*01 and HLA-DRB1*16, or with DRB1*0101, DRB1*0103 and DQB1*0501, respectively. Associations with HLA class II alleles have also been shown with allergies to cockroach (Donfack et al 2000;Kalpaklioglu and Turan 2002) and rat (Jeal et al 2003).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Association of HLA class II alleles with sensitization to cow dander Bos d 2, an important occupational allergen

et al. 2012

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association of HLA class II alleles with sensitization to cow dander Bos d 2, an important occupational allergen

et al. 2012

View full text Add to dashboard Cite

“…For instance, HLA-B*18 and HLA-Cw*07 were significantly more frequent among Turkish bee-and/or wasp venom-allergic patients (135). Among HLA class II genotypes, DRB1*0101, DRB1*0103, DQA1*0101, and DQB1*0501 were found to be associated with an increased risk of being sensitized to Api m 1 (136). Still, to our knowledge, no conclusive statement regarding HLA class I and II frequencies and venom allergy or risk of SR is possible.…”

Section: Genetic Markersmentioning

confidence: 67%

Precision Medicine in Hymenoptera Venom Allergy: Diagnostics, Biomarkers, and Therapy of Different Endotypes and Phenotypes

et al. 2020

View full text Add to dashboard Cite

Allergic reactions to stings of Hymenoptera species may be severe and are potentially fatal deviations of the immunological response observed in healthy individuals. However, venom-specific immunotherapy (VIT) is an immunomodulatory approach able to cure venom allergy in the majority of affected patients. An appropriate therapeutic intervention and the efficacy of VIT not only depend on a conclusive diagnosis, but might also be influenced by the patient-specific manifestation of the disease. As with other diseases, it should be borne in mind that there are different endotypes and phenotypes of venom allergy, each of which require a patient-tailored disease management and treatment scheme. Reviewed here are different endotypes of sting reactions such as IgE-mediated allergy, asymptomatic sensitization or a simultaneous presence of venom allergy and mast cell disorders including particular considerations for diagnosis and therapy. Additionally, phenotypical manifestations of venom allergy, as e.g. differences in age of onset and disease severity, multiple sensitization or patients unsusceptible to therapy, are described. Moreover, biomarkers and diagnostic strategies that might reflect the immunological status of the patient and their value for therapeutic guidance are discussed. Taken together, the increasing knowledge of different disease manifestations in venom hypersensitivity and the growing availability of diagnostic tools open new options for the classification of venom allergy and, hence, for personalized medical approaches and precision medicine in Hymenoptera venom allergy.

show abstract

Current World Literature

2006

Current Opinion in Allergy &Amp; Clinical Immunology

View full text Add to dashboard Cite

Sensitivity to Bee Venom Antigen Phospholipase A2: Association With Specific HLA Class I and Class II Alleles and Haplotypes in Beekeepers and Allergic Patients

Cited by 4 publications

References 36 publications

Association of HLA class II alleles with sensitization to cow dander Bos d 2, an important occupational allergen

Association of HLA class II alleles with sensitization to cow dander Bos d 2, an important occupational allergen

Precision Medicine in Hymenoptera Venom Allergy: Diagnostics, Biomarkers, and Therapy of Different Endotypes and Phenotypes

Current World Literature

Contact Info

Product

Resources

About