Sensitivity to antitubulin chemotherapeutics is potentiated by a photoactivable nanoliposome

Wang, Xiaobing; Liu, Xiufang; Li, Yixiang; Wang, Pan; Feng, Xiaolan; Liu, Quanhong; Yan, Fei; Zheng, Hairong

doi:10.1016/j.biomaterials.2017.06.034

Cited by 44 publications

(23 citation statements)

References 59 publications

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“…With decades of research, the development of liposomes has gone through several generations. With regard to cancer therapy, liposomes provide a good platform for in vivo delivery of many anti-tumor drugs, such as doxorubicin and paclitaxel, among other chemotherapeutic agents, as well as nucleic acids (Chen et al, 2010;Wang X. et al, 2017). In the field of breast and prostate cancer (Yari et al, 2019), the application of liposomes has been increasingly common (Satsangi et al, 2015;Tang B. et al, 2020).…”

Section: Organic Npsmentioning

confidence: 99%

Nanoparticle-Based Drug Delivery in Cancer Therapy and Its Role in Overcoming Drug Resistance

Yao

Zhou

Liu

et al. 2020

Front. Mol. Biosci.

599

346

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Nanotechnology has been extensively studied and exploited for cancer treatment as nanoparticles can play a significant role as a drug delivery system. Compared to conventional drugs, nanoparticle-based drug delivery has specific advantages, such as improved stability and biocompatibility, enhanced permeability and retention effect, and precise targeting. The application and development of hybrid nanoparticles, which incorporates the combined properties of different nanoparticles, has led this type of drug-carrier system to the next level. In addition, nanoparticle-based drug delivery systems have been shown to play a role in overcoming cancer-related drug resistance. The mechanisms of cancer drug resistance include overexpression of drug efflux transporters, defective apoptotic pathways, and hypoxic environment. Nanoparticles targeting these mechanisms can lead to an improvement in the reversal of multidrug resistance. Furthermore, as more tumor drug resistance mechanisms are revealed, nanoparticles are increasingly being developed to target these mechanisms. Moreover, scientists have recently started to investigate the role of nanoparticles in immunotherapy, which plays a more important role in cancer treatment. In this review, we discuss the roles of nanoparticles and hybrid nanoparticles for drug delivery in chemotherapy, targeted therapy, and immunotherapy and describe the targeting mechanism of nanoparticle-based drug delivery as well as its function on reversing drug resistance.

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Section: Organic Npsmentioning

confidence: 99%

Nanoparticle-Based Drug Delivery in Cancer Therapy and Its Role in Overcoming Drug Resistance

Yao

Zhou

Liu

et al. 2020

Front. Mol. Biosci.

599

346

View full text Add to dashboard Cite

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“…A variety of organic materials such as liposomes, block copolymer micelles, and lipid particles have been tested as vehicles. The advantages of liposomes as compared to other systems are their ability to deliver hydrophilic and hydrophobic substances, as well as the fact that they have clinical acceptance.…”

Section: Photodynamic Therapy and Chemotherapymentioning

confidence: 99%

“…Recently, Wang et al have demonstrated the encapsulation of PTX and the photosensitizer sinoporphyrin sodium (DVDMS) in liposomes for the treatment of a MCF‐7 (breast cancer) xenografted model. [89a] In vitro studies have shown that the dual‐loaded liposomes mainly accumulate in the cytoplasm. The ROS produced upon laser irradiation have caused mitochondrial dysfunction and thus have sensitized cell apoptosis by PTX, showing again how two different therapeutic modalities can enhance one another.…”

Section: Photodynamic Therapy and Chemotherapymentioning

confidence: 99%

Nanocarrier‐Mediated Photochemotherapy and Photoradiotherapy

Denkova

Kruijff

Serra‐Crespo

2017

Adv Healthcare Materials

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Photothermal therapy (PTT) and photodynamic therapy (PDT) both utilize light to induce a therapeutic effect. These therapies are rapidly gaining importance due to the noninvasiveness of light and the limited adverse effect associated with these treatments. However, most preclinical studies show that complete elimination of tumors is rarely observed. Combining PDT and PTT with chemotherapy or radiotherapy can improve the therapeutic outcome and simultaneously decrease side effects of these conventional treatments. Nanocarriers can help to facilitate such a combined treatment. Here, the most recent advancements in the field of photochemotherapy and photoradiotherapy, in which nanocarriers are employed, are reviewed.

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“…In order to reduce solvent hypersensitivity risks, improve body distribution target, and enhance the human body's tolerance to PTX, liposomal formulation (Lipusu ® approved by state FDA of PR China) and the albumin-based formulation of PTX have been used in clinical application. [2][3][4] The tumor cell killing efficiency of PTX and its drug resistance were not settled appropriately. Therefore, the challenge to improve the cancer cell sensitivity of PTX and simultaneously reduce its undesirable side effects still remains.…”

Section: Introductionmentioning

confidence: 99%

<p>Combined administration of PTX and S-HM-3 in TPGS/Solutol micelle system for oncotarget therapy</p>

Xue

2019

IJN

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BackgroundS-HM-3 is a tumor angiogenesis inhibitor with short half-life (25 min). In this present, TPGS/Solutol polymeric micelles was prepared to load together insoluble paclitaxel (PTX) and soluble S-HM-3, expecting to together deliver them to the tumor site with long-circulating, targeting function and combating multi-drug resistance (MDR).Materials and methodsPTX and S-HM-3 loaded TPGS/Solutol micelles (PHTSm) were prepared by the method of thin-film evaporation, and characterized by dynamic light scattering, transmission electron microscope (TEM), atomic force microscopy (AFM) and releasing properties. The anticancer effect of the polymeric micelles system was evaluated and confirmed by experiments of in vitro cell uptake study, in vivo pharmacokinetics, and pharmacodynamics studies.ResultsMicelles exhibited smooth spherical morphology with 20~30 nm and low critical micelle concentration (CMC) value of 0.000124 mg/mL. Only about 30% of PTX were slowly released from micelles at 48h, which can beneficial to the long circulation in blood. The results of in vitro cell assay proved that S-HM-3 could be easier to get into MDA-MB-231 cell, and its angiogenesis inhibition ability was also enhanced after integrating into micelles. In particular, the results of in vivo studies showed that the half-life of S-HM-3 and PTX was significantly prolonged 25.27 and 5.54 folds, and their AUC0–∞ was enhanced 129.78 and 15.65 times, respectively. Meanwhile 83.05% tumor inhibition rate of PHTSm was achieved compared with 59.99% of PTX.ConclusionsTPGS and Solutol micelles hold promising potential to resolve the conundrum of combined therapy of cytotoxic drug and angiogenesis inhibitor with different physicochemical property and anticancer mechanism in clinical use.

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Sensitivity to antitubulin chemotherapeutics is potentiated by a photoactivable nanoliposome

Cited by 44 publications

References 59 publications

Nanoparticle-Based Drug Delivery in Cancer Therapy and Its Role in Overcoming Drug Resistance

Nanoparticle-Based Drug Delivery in Cancer Therapy and Its Role in Overcoming Drug Resistance

Nanocarrier‐Mediated Photochemotherapy and Photoradiotherapy

<p>Combined administration of PTX and S-HM-3 in TPGS/Solutol micelle system for oncotarget therapy</p>

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