Nanocarrier‐Mediated Photochemotherapy and Photoradiotherapy

Denkova, Antonia G.; Kruijff, Robin M. de; Serra‐Crespo, Pablo

doi:10.1002/adhm.201701211

Cited by 49 publications

(27 citation statements)

References 157 publications

(148 reference statements)

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“…Yoon et al7 have found that PDT with ALA-hx (hexenyl ester of 5-aminolaevulinic acid) more efficiently produced reactive oxygen species (ROS) and suppressed MCF-7/ADR cells viability; the findings suggest that ALA-hx PDT may be used as a therapeutic alternative for drug-resistant breast cancer 7. In addition, the combination of PDT and chemotherapy always has potential advantages compared with traditional treatments, such as high selectivity, minimal invasiveness, and effectiveness in overcoming chemotherapy drug resistance 8–10…”

Section: Introductionmentioning

confidence: 99%

<p>Magnetic And pH Dual-Responsive Nanoparticles For Synergistic Drug-Resistant Breast Cancer Chemo/Photodynamic Therapy</p>

Wang¹,

Li²,

Li³

et al. 2019

IJN

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BackgroundDrug resistance is one of the prime reasons of chemotherapy failure in breast cancer and is also an important factor affecting prognosis.PurposeIn this study, we constructed a functional magnetic mesoporous silica-based nanocomposite (MMSN) for breast cancer chemotherapy/photodynamic therapy.MethodsMMSN was characterized by scanning electron microscopy and transmission electron microscopy to observe the morphology. The size distribution and zeta potential of the MSNs were determined using Malvern Particle Size Analyzer. Anti-tumor activity in vitro was investigated by CCK-8 assay, flow cytometry and transwell experiment, and the anti-tumor activity in vivo was probed into by magnetic targeting, toxicity, and antitumor effects in breast cancer-bearing BABL/c nude mice.ResultsThe results showed that the release of doxorubicin in the nanocomposites was pH sensitive, and the cumulative release rate reached 80.53% at 60 h under acidic conditions. The nanocomposites had a high cellular uptake ability in MCF-7/ADR cells, and the IC50 value of the nanocomposites on MCF-7/ADR cells was 4.23 μg/mL, much smaller than that of free DOX (363.2 μg/mL). The nanocomposites could effectively reverse resistance and induce apoptosis of MCF-7/ADR cells. The blood biochemistry parameters and H&E staining results showed no serious adverse effects after treatment with the nanocomposites. Prussian blue staining showed that the nanocomposites were able to target tumor tissues in tumor-bearing mice under a magnetic field. The combined chemical/photodynamic therapy significantly inhibited tumor growth in vivo.ConclusionNanocomposites with magnetic and pH dual-responsive performance has shown a promising platform for enhanced drug-resistant breast cancer treatment.

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Section: Introductionmentioning

confidence: 99%

<p>Magnetic And pH Dual-Responsive Nanoparticles For Synergistic Drug-Resistant Breast Cancer Chemo/Photodynamic Therapy</p>

Wang¹,

Li²,

Li³

et al. 2019

IJN

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“…Therefore, it is a tendency to explore nanomaterials with excellent biocompatibility which can be prepared by a simple synthesis. Moreover, light source plays a vital role in PDT and PTT, so it is indispensable to find the ideal wavelength of light [ 203 , 204 ].…”

Section: Chemo-photothermal Combination Therapymentioning

confidence: 99%

Nanotechnology for Cancer Therapy Based on Chemotherapy

et al. 2018

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Chemotherapy has been widely applied in clinics. However, the therapeutic potential of chemotherapy against cancer is seriously dissatisfactory due to the nonspecific drug distribution, multidrug resistance (MDR) and the heterogeneity of cancer. Therefore, combinational therapy based on chemotherapy mediated by nanotechnology, has been the trend in clinical research at present, which can result in a remarkably increased therapeutic efficiency with few side effects to normal tissues. Moreover, to achieve the accurate pre-diagnosis and real-time monitoring for tumor, the research of nano-theranostics, which integrates diagnosis with treatment process, is a promising field in cancer treatment. In this review, the recent studies on combinational therapy based on chemotherapy will be systematically discussed. Furthermore, as a current trend in cancer treatment, advance in theranostic nanoparticles based on chemotherapy will be exemplified briefly. Finally, the present challenges and improvement tips will be presented in combination therapy and nano-theranostics.

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“…优点是PTT驱动诱导肿瘤内热疗, 同时增加肿瘤组织内的血流量, 改善氧合作用, 从而使细胞对辐射更敏感. 用于该组合的纳米材料呈现高NIR吸光值并且可以产生局部的温度升高, 同时具有放射增敏作用 [96] . Li等人 [97]…”

Section: 通过Ptt升高局部肿瘤温度进行的热疗已被证明是Rt的有力增强剂结合这两种治疗方案的主要unclassified