Sensitivity of Danio rerio (Teleostei, Cyprinidae) During Two Stages of Development Based on Acute Toxicity Tests

Freiry, Raquel Fontoura; Stelzer, Julio Alberto Alegre; Maltchik, Leonardo; Arenzon, Alexandre

doi:10.1007/s00128-014-1367-6

Cited by 11 publications

(4 citation statements)

References 3 publications

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“…Eggs were microscopically checked for fertility (overall fertility >90%) and viability. For the FET, embryos were used up to 90 min post fertilization, and for other comparative methods the organisms were nurtured until they had reached the appropriate age/size for testing following Freiry et al (). For all replicates, mortality rates of spawning events were <20% up to the latest life stage tested (juveniles).…”

Section: Methodsmentioning

confidence: 99%

Is fish embryo test (FET) according to OECD 236 sensible enough for delivering quality data for effluent risk assessment?

Stelzer

Rosin

Bauer

et al. 2018

Enviro Toxic and Chemistry

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Over the past few years, the fish embryo test (FET) has become widely accepted as an animal-friendly protocol for ecotoxicological research. As Organisation for Economic Co-operation and Development (OECD) 236, the FET has been widely applied for simple mixture exposures under the Registration, Evaluation, Authorisation, and Restriction of Chemicals regulation of the European Union; and now its use is spreading worldwide as a supposedly reliable whole-effluent test (i.e., the testing of complex mixture exposures). However, comparative peer-reviewed data regarding the FET's efficiency for whole-effluent tests are virtually nonexistent. The primary objective of the present study was to make the first comparative test between the FET according to OECD 236 and other standard and slightly modified standard fish protocols used worldwide for whole-effluent tests. For that, we used an untreated hospital effluent considered to be highly toxic but disposed of in municipal sewerage. The base methods were OECD 203 (juvenile), US Environmental Protection Agency method 2000.0 (larvae), and OECD 236 (embryo). We also evaluated the addition of 3 virtually costless sublethal metrics (immobility, nonhatching, and pericardial edema) that could enhance the sensitivity of OECD 236. We observed acute toxicity in all 8 methodologies tested, with a clear escalation in sensitivity (larvae > juvenile ≥ embryo). Larvae were the most sensitive life stage for whole-effluent tests. The addition of sublethal metrics to OECD 236 enhanced its previous sensitivity in over 30%. Thus we conclude that OECD 236 acts below its potential and that the embryonic stage (as used in the FET) may not be the most sensitive life stage for whole-effluent tests. Environ Toxicol Chem 2018;37:2925-2932. © 2018 SETAC.

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Section: Methodsmentioning

confidence: 99%

Is fish embryo test (FET) according to OECD 236 sensible enough for delivering quality data for effluent risk assessment?

Stelzer

Rosin

Bauer

et al. 2018

Enviro Toxic and Chemistry

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show abstract

“…The difference in toxicity between road salt and NaCl was attributed to the presence of other chemicals in road salt (such as cyanide) which might increase its toxicity to fish. Another study by Freiry et al, (2014) examined the differences in sensitivity of the zebrafish ( Danio rerio ) to three chemicals, including NaCl, at two stages of development. The results implied that the larval phase (10 days after hatching) of D .…”

Section: Impacts Of Deicers On Aquatic Resourcesmentioning

confidence: 99%

“…The results implied that the larval phase (10 days after hatching) of D . rerio is more sensitive (48‐h LC50 of 6.75 g/L) to NaCl than the post‐larval phase (60 days after hatching) with 48‐h LC50 of 8.9 g/L (Freiry et al, 2014). This study showed that the post‐larval stage of D .…”

Section: Impacts Of Deicers On Aquatic Resourcesmentioning

confidence: 99%

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Toxicological impacts of roadway deicers on aquatic resources and human health: A review

Nazari

Potapova

McIntyre

et al. 2021

Water Environment Research

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During winter, snow and ice on roads in regions with cold weather can increase traffic crashes and casualties, resulting in travel delays and financial burdens to society. Anti‐icing or deicing the roads can serve a cost‐effective method to significantly reduce such risks. Although traditionally the main priorities of winter road maintenance (WRM) have been level of service, cost‐effectiveness, and corrosion reduction, it is increasingly clear that understanding the environmental impacts of deicers is vital. One of the most important problems in this regard is environmental contamination caused by cumulative use of deicers, which has many detrimental effects on the aquatic systems. Among the deicers, the chloride‐based ones raise the most toxicological concerns because they are highly soluble, can migrate quickly in the environment and have cumulative effects over time. In this review, we summarize and organize existing data, including the latest findings about the adverse effects of deicers on surface water and groundwater, aquatic species, and human health, and identify future research priorities. In addition, the data provided can be used to develop a framework for quantifying some of the variables that stakeholders and agencies use when preparing guidelines and standards for WRM programs. Practitioner points Pollution from the increasing use of roadway deicers may have detrimental effects on the environment. Of particular concern are the acute and cumulative risks that chloride salts pose to aquatic species. Chloride salts are water‐soluble, very difficult to remove, highly mobile, and non‐degradable. Deicers cause water stratification, change the chemicophysical properties of water, and affect aquatic species and human health. Current guidelines may not be appropriate for environmental protection and need to be revised.

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Identifying Behavioral Response Profiles of Two Common Larval Fish Models to a Salinity Gradient

Scarlett

Lovin

Steele

et al. 2022

Arch Environ Contam Toxicol

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Sensitivity of Danio rerio (Teleostei, Cyprinidae) During Two Stages of Development Based on Acute Toxicity Tests

Cited by 11 publications

References 3 publications

Is fish embryo test (FET) according to OECD 236 sensible enough for delivering quality data for effluent risk assessment?

Is fish embryo test (FET) according to OECD 236 sensible enough for delivering quality data for effluent risk assessment?

Toxicological impacts of roadway deicers on aquatic resources and human health: A review

Identifying Behavioral Response Profiles of Two Common Larval Fish Models to a Salinity Gradient

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