Accurate monitoring of exposure to organic vapors, such as acetone, is an important part of maintaining a safe working environment and adhering to long-and short-term exposure limits.Here, a novel acetone vapor detection system is described based on the use of a reactive chiral dopant in a nematic liquid crystal thin film, which can accurately monitor the total exposure over a given timeframe through changes in the reflection band of the film. It was found that films exposed to 1000 parts per million by volume (ppmv) of acetone vapor for two hours exhibited a shift in reflection band of 12 nm, with smaller shifts observed at lower concentrations of acetone. Such sensors have potential applications in industrial hygiene.