Sensitivity and specificity of Munro microabscess detected by reflectance confocal microscopy in the diagnosis of psoriasis vulgaris

Zhong, Liansheng; Wei, Zhiyuan; Yan-qun, Liu

doi:10.1111/j.1346-8138.2011.01366.x

Cited by 16 publications

(30 citation statements)

References 5 publications

(4 reference statements)

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“…showed a high sensitivity (90·0%) and specificity (96·4%) for Munro microabscesses. (Pseudo)Pautrier microabscesses may resemble Munro microabscesses; however, cells in Pautrier microabscesses were less refractile and smaller …”

Section: Resultsmentioning

confidence: 99%

“…Fifteen studies revealed RCM features for diagnostic and monitoring applications in psoriasis (Table ) . The most observed features were parakeratosis, thinning or absence of the stratum granulosum (SG), Munro microabscesses, infiltrating cells in the epidermis, nonedged dermal papillae (DP), papillomatosis and tortuous, twisted and dilated blood vessels (BV) in DP (Tables and S4).…”

Section: Resultsmentioning

confidence: 99%

“…In PRP, a lack of neutrophils, maintenance of the SG, and irregular‐shaped and sized DP at the dermoepidermal junction (DEJ) were observed . Zhong et al . showed a high sensitivity (90·0%) and specificity (96·4%) for Munro microabscesses.…”

Section: Resultsmentioning

confidence: 99%

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The value ofin vivoreflectance confocal microscopy in the diagnosis and monitoring of inflammatory and infectious skin diseases: a systematic review

et al. 2015

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In vivo examination of the skin by reflectance confocal microscopy (RCM) has been performed for about 20 years, leading to a broad spectrum of imaged infectious and inflammatory skin diseases (ISD) with many described RCM features. We systematically reviewed all available literature concerning ISD evaluated by RCM. Furthermore, we assessed the accuracy of the features and defined recommendations for future studies after indicating the limitations in the current published literature. PubMed, Embase, Cochrane Library and Web of Science databases were searched for literature. All studies on RCM and ISD were reviewed and quality assessment was determined by using the STrengthening the Reporting of OBservational studies in Epidemiology (STROBE) checklist. The literature search revealed 77 eligible studies for inclusion. Different RCM features in a broad spectrum of ISD have been described. Further, RCM has been used for monitoring treatment and evolution of ISD, as well as for diagnostic purposes. This systematic review provides an overview of the broad spectrum of ISD imaged by RCM. Although RCM seems to be a promising monitoring and diagnostic tool for ISD, studies with appropriate methodological quality are necessary to create adequate guidelines and protocols for further implementation of RCM in clinical practice.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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The value ofin vivoreflectance confocal microscopy in the diagnosis and monitoring of inflammatory and infectious skin diseases: a systematic review

et al. 2015

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“…Within the 11 702 studies identified from the search strategy no clinical examination‐based diagnostic criteria for psoriasis in adults or children were found. Only 23 studies met the inclusion criteria; they presented a broad range of diagnostic criteria including genetic, molecular, dermoscopy, confocal microscopy, histopathology, questionnaire‐based, computer‐aided and traditional Chinese medicine criteria (Table S1; see Supporting Information). Sixteen studies were of a case–control design, five studies were case series, one study was cross‐sectional and one study was a Delphi consensus study.…”

Section: Resultsmentioning

confidence: 99%

“…These scores reflect not only the study quality but also the quality of study reporting; for example the details reported by Liu et al . and Zhong et al . were brief and therefore many of the domains were scored as unclear.…”

Section: Resultsmentioning

confidence: 99%

A systematic review of diagnostic criteria for psoriasis in adults and children: evidence from studies with a primary aim to develop or validate diagnostic criteria

et al. 2018

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Assessment of atopic dermatitis in all phototypes using line‐field confocal optical coherence tomography (LC‐OCT) and reflectance confocal microscopy (RCM)

Ouellette,

Truong,

Khan

et al. 2024

JEADV Clinical Practice

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BackgroundTheclinical presentation of atopic dermatitis (AD) varies in different skin phototypes and has been evaluated previously using reflectance confocal microscopy (RCM). Line‐field confocal optical coherence tomography (LC‐OCT) is a new noninvasive imaging modality with additional capabilities.ObjectivesThis prospective cohort study aimed to assess the capabilities of LC‐OCT and RCM in visualizing and quantifying microscopic features of AD lesions.MethodsTen patients with clinically diagnosed AD and visible active lesions were included in the study. LC‐OCT and RCM imaging were performed on lesional and perilesional skin during routine dermatology visits. Image analysis included quantitative measurements of living and total epidermal thickness and dermo‐epidermal junction (DEJ) undulation using LC‐OCT, as well as visual assessment of characteristic features such as spongiosis, exocytosis, perivascular inflammation, and atypical blood vessels using both LC‐OCT and RCM.ResultsLC‐OCT provided precise measurements of epidermal landmarks and shared similar microscopic features compared to RCM. AD lesions exhibited increased stratum corneum thickness, living epidermis thickness, total epidermis thickness, and DEJ undulation compared to clinically normal skin. Spongiosis, exocytosis, perivascular inflammation, blood vessel proliferation, and dilation were prominent features observed in AD lesions on both LC‐OCT and RCM images. Interestingly, some inflammatory features were also detected in the visually normal skin of AD patients.ConclusionsLC‐OCT showed potential as a fast and noninvasive imaging tool for assessing inflammatory skin pathologies, including AD. Its ability to visualize microscopic features and quantify epidermal changes may aid in diagnosis and treatment monitoring. These findings suggest that LC‐OCT could provide valuable insights, particularly for patients with darker skin types where clinical severity assessment may be challenging. Further studies are warranted to explore the full potential of LC‐OCT and its integration into clinical practice.

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Sensitivity and specificity of Munro microabscess detected by reflectance confocal microscopy in the diagnosis of psoriasis vulgaris

Cited by 16 publications

References 5 publications

The value ofin vivoreflectance confocal microscopy in the diagnosis and monitoring of inflammatory and infectious skin diseases: a systematic review

The value ofin vivoreflectance confocal microscopy in the diagnosis and monitoring of inflammatory and infectious skin diseases: a systematic review

A systematic review of diagnostic criteria for psoriasis in adults and children: evidence from studies with a primary aim to develop or validate diagnostic criteria

Assessment of atopic dermatitis in all phototypes using line‐field confocal optical coherence tomography (LC‐OCT) and reflectance confocal microscopy (RCM)

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