Sensitive Ratiometric Fluorescent Metal-Organic Framework Sensor for Calcium Signaling in Human Blood Ionic Concentration Media

Abstract

A two-dimensional fluorescent metal-organic framework (MOF) sensor, TMU-5S, was synthesized by introducing rhodamine B into the framework of TMU-5. This dye-sensitized MOF was explored as a ratiometric fluorescent sensor for Ca2+ signaling in the presence of interfering cations in ionic concentrations similar to that of blood plasma that exhibits exceptional sensitivity and selectivity to Ca2+ and faster response and recovery times than any other reported fluorescent sensor. This can be attributed to strong electrostatic interactions between basic azine groups in the narrow pore walls of TMU-5S and Ca2+ as hard–hard acid–base interactions. The results show that the two-dimensional signal transduction can reduce interfering responses from the environment and thus create exceptional sensitivity.

Electrodeposited Metal Organic Framework toward Excellent Hydrogen Sensing in an Ionic Liquid

“…MOFs are a new class of functional porous materials with inorganic and organic species arranged in a regular pattern. − The inorganic component in MOFs is usually a metal or metal oxide node, and the organic part is a multidentate ligand such as a benzene carboxylic acid. The metal and ligand can be arranged in specific patterns to form one-dimensional (1D), two-dimensional (2D), and three-dimensional (3D) nanoporous materials.…”

Specific Coordination between Zr-MOF and Phosphate-Terminated DNA Coupled with Strand Displacement for the Construction of Reusable and Ultrasensitive Aptasensor

“…A metal–organic framework (MOF) is a three-dimensional porous nanomaterial. , The high surface area, abundant metal active sites, and convenient modification enable the MOF to be used as an outstanding sensing material candidate in the development of high-performance biosensors. , A typical example is the Zr-based MOF that shows a high affinity toward phosphate groups (−PO 4 3– ) by forming a strong Zr–O–P coordination bond, leading to its capacity for the highly selective and effective accumulation of phosphate-contained biomolecules . On the basis of this feature, Mirkin et al fabricated the PO 4 3– -terminated DNA on the surface of UiO-66 nanoparticles, which was used to detect the cellular endotoxin.…”

Sensing Intra‐ and Extra‐Cellular Ca2+ in the Islet of Langerhans

“…The results also showed that TMU‐5S preferentially binds to Ca 2+ over other metal cations at physiological concentrations, and exhibits a 5‐s response (the time required to obtain the 90% real value) and 40‐s recovery (the time for releasing up to 90% from a specific target). [ 125 ] The temporal responsiveness is sufficient for tracing slow Ca 2+ changes, but may be too protracted for fast‐tracking or instantaneous reading of [Ca 2+ ] changes.…”