Sensitive monitoring and bioimaging intracellular highly reactive oxygen species based on gold nanoclusters@nanoscale metal-organic frameworks

Cao, Xuanyu; Cheng, Shasha; You, Yi; Zhang, Shiming; Luo, Xianzhu

doi:10.1016/j.aca.2019.09.051

Cited by 37 publications

(25 citation statements)

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“…Due to the small size of precious MNCs, a suitable template preparation (such as glutathione) is chosen to make them quickly cleared by the kidneys and are therefore discharged out of the body after biological imaging [80,81]. While targeting tumor cells, precious MNCs can also provide sufficient information on cancer cells by detecting other substances in the organism (such as a high concentration of reactive oxygen species [82], PH value [83], etc.).…”

Section: Noble Mncs In Biotargeting and Bioimagingmentioning

confidence: 99%

Biological nanoscale fluorescent probes: From structure and performance to bioimaging

Wan

Zhang

et al. 2020

Reviews in Analytical Chemistry

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In recent years, nanomaterials have attracted lots of attention from researchers due to their unique properties. Nanometer fluorescent materials, such as organic dyes, semiconductor quantum dots (QDs), metal nano-clusters (MNCs), carbon dots (CDs), etc., are widely used in biological imaging due to their high sensitivity, short response time, and excellent accuracy. Nanometer fluorescent probes can not only perform in vitro imaging of organisms but also achieve in vivo imaging. This provides medical staff with great convenience in cancer treatment. Combined with contemporary medical methods, faster and more effective treatment of cancer is achievable. This article explains the response mechanism of three-nanometer fluorescent probes: the principle of induced electron transfer (PET), the principle of fluorescence resonance energy transfer (FRET), and the principle of intramolecular charge transfer (ICT), showing the semiconductor QDs, precious MNCs, and CDs. The excellent performance of the three kinds of nano fluorescent materials in biological imaging is highlighted, and the application of these three kinds of nano fluorescent probes in targeted biological imaging is also introduced. Nanometer fluorescent materials will show their significance in the field of biomedicine.

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Section: Noble Mncs In Biotargeting and Bioimagingmentioning

confidence: 99%

Biological nanoscale fluorescent probes: From structure and performance to bioimaging

Wan

Zhang

et al. 2020

Reviews in Analytical Chemistry

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“…Hence, monitoring the concentration of hROS is crucial and can also be accomplished by MOF/AuNCs assemblies. For instance, glutathione-protected AuNCs were encapsulated into ZIF-8 in situ, yielding AuNCs@ZIF-8 nanocomposites with increased fluorescence intensity and lifetime [ 87 ]. The fluorescence intensity of AuNCs@ZIF-8 was enhanced approximately ten fold that of GSH–AuNCs, possessing high quantum yield of 11%.…”

Section: Luminescence Sensingmentioning

confidence: 99%

Metal–Organic Frameworks-Mediated Assembly of Gold Nanoclusters for Sensing Applications

Wang

Tan

et al. 2022

J. Anal. Test.

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Gold nanoclusters (AuNCs) are an emerging type of ultrasmall nanomaterials possessing unique physicochemical characteristics. Metal–organic frameworks (MOFs), a singular kind of porous solid and crystalline material, have attracted tremendous attention in recent years. The combination of AuNCs and MOFs can integrate and improve the prominent properties of both components, such as high catalytic activities, tunable optical properties, good biocompatibility, surface functionality and stability, which make the composites of MOFs and AuNCs promising for sensing applications. This review systematically summarizes the recent progress on the sensing of various analytes via MOFs-mediated AuNCs assemblies based on strategies of luminescence sensing, colorimetric sensing, electrochemiluminescence sensing, and electrochemical and photoelectrochemical sensing. A brief outlook regarding the future development of MOFs-mediated AuNCs assemblies for sensing application is presented as well.

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“…Recently, another work was also reported on the synthesis of Au NCs@NMOFs and their application of live‐cell imaging. [ 61 ] Similarly, GSH stabilized gold nanoclusters were successfully encapsulated in ZIF‐8 via in situ growth. It is worth noting that the fluorescence intensity of Au NCs@NMOFs increased by 10 times and the QY was up to about 11%, attributed to the aggregation‐induced emission (AIE) of Au NCs.…”

Section: Mofs For Fluorescence Imaging In Living Cellsmentioning

confidence: 99%

Metal‐Organic Frameworks‐Based Fluorescent Nanocomposites for Bioimaging in Living Cells and in vivo^†

et al. 2021

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Metal‐organic frameworks (MOFs) as a class of porous functional materials have attracted more and more attention for biomedical applications. To date, MOFs have been developed for bioimaging based on a series of advantages such as the large surface areas, high porosity, fluorescence functionalities and good biocompatibility. It is worth noting that organic or inorganic fluorescent materials such as fluorescent dyes, quantum dots, metal nanoclusters and nanosheets can combine MOFs or be encapsulated in MOFs to form fluorescent nanocomposites for excellent imaging function. Importantly, excellent imaging capabilities are of great significance in living cells and in vivo for detection, diagnosis and cancer therapy. In this review, we focus on the recent research of the bioimaging in living cells and in vivo based on various MOF‐based nanocomposites and their potential biological clinical applications.

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Sensitive monitoring and bioimaging intracellular highly reactive oxygen species based on gold nanoclusters@nanoscale metal-organic frameworks

Cited by 37 publications

References 50 publications

Biological nanoscale fluorescent probes: From structure and performance to bioimaging

Biological nanoscale fluorescent probes: From structure and performance to bioimaging

Metal–Organic Frameworks-Mediated Assembly of Gold Nanoclusters for Sensing Applications

Metal‐Organic Frameworks‐Based Fluorescent Nanocomposites for Bioimaging in Living Cells and in vivo^†

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Sensitive monitoring and bioimaging intracellular highly reactive oxygen species based on gold nanoclusters@nanoscale metal-organic frameworks

Cited by 37 publications

References 50 publications

Biological nanoscale fluorescent probes: From structure and performance to bioimaging

Biological nanoscale fluorescent probes: From structure and performance to bioimaging

Metal–Organic Frameworks-Mediated Assembly of Gold Nanoclusters for Sensing Applications

Metal‐Organic Frameworks‐Based Fluorescent Nanocomposites for Bioimaging in Living Cells and in vivo†

Contact Info

Product

Resources

About

Metal‐Organic Frameworks‐Based Fluorescent Nanocomposites for Bioimaging in Living Cells and in vivo^†