Sensitive kinetic spectrophotometric determination of captopril and ethamsylate in pharmaceutical preparations and biological fluids

Indirect spectrophotometric method for determination of captopril using Cr(VI) and diphenylcarbazide

“…Moreover, some of the reported methods are alike or more sensitive but have drawbacks such as having a narrow linear dynamic range, 18,24,27,33 or involving organic solvents 13,30 and heating. 24 …”

“…19 Numerous spectrophotometric methods have also been proposed for CP determination. 1,[20][21][22][23][24][25][26][27][28][29][30][31][32][33] Generaly, these approaches involve the use of reagents that react with this compound to form species with absorb in the visible region. The US Pharmacopoeia recommends volumetric and HPLC methods for the assay in bulk and tablet formulations.…”

A Novel Use of 3-Methyl-2-Benzothiazolinone Hydrazone Hydrochloride Monohydrate for Kinetic Spectrophotometric Determination of Captopril in Pharmaceutical Formulations

“…As it is seen in this table, some of the reported procedures are more sensitive but have drawbacks such as having a narrow linear range [11][12][13], involving heating [11], and some methods are not simple and required expensive or sophisticated instruments [10]. …”

“…About 30% of the drug is bound to plasma protein [2][3]. In order to assure the quality of CPT containing pharmaceutical formulations, several analytical methods have been reported for its determination, including spectrophotometric [4][5][6][7][8][9], kinetic spectrophotometric methods [10][11][12][13], high performance liquid chromatography (HPLC) [14][15][16], polarography [17], stripping voltammetry [18][19], fluorimetry [20], atomic absorption spectrophotometry [21], flow injection analysis [22][23][24][25],and potentiometry [26].…”

Application and Equivalence Assessment for Determining Ethamsylate by Using Potassium Ferricyanide as Spectroscopic Probe Reagent

“…1 This agent is commonly given for the prophylaxis and control of hemorrhages from small blood vessels in surgery and clinical conditions. [2][3][4] Although this compound has been extensively applied for clinical purposes, only a few methods have been reported for the quantitative determination of ethamsylate in pharmaceutical and biological fluids; these include spectrophotometry, 1 electrochemistry, [5][6][7] chemiluminescence, 8 and HPLC method. 9 Equivalence assessment will demonstrate that results obtained will not differ importantly when different methods are used for the same intent.…”