Sensitive determination of Anastrozole and Letrozole in urine samples by novel magnetic nanoparticles containing tetraethylenepentamine (TEPA) prior to analysis by high-performance liquid chromatography-diode array detection

In the current work, a new type of micelle is designed that has active connectivity in respond to exterior stimulus and the desired water solubility. Two end-ornamented homopolymers, polystyrene-beta-cyclodextrin (PS-β-CD) and polyethylene oxide-ferrocene (PE-FE), can aggregate as a supramolecular micelle (PS-β-CD/PE-FE) by the guest–host interactions. Our results showed that the Lennard–Jones and hydrophobic interactions are the main powerful forces for the micelle formation process. It was found that the electrical field plays a role as a driving force in the reversible assembly-disassembly of the micellar system. Moreover, for the first time, we examined the PS-β-CD/PE-FE micelle interaction as a drug delivery system with anastrozole (ANS) and mitomycin C (MIC) anti-cancer drugs. The investigation of the total energy between PS-β-CD/PE-FE micelle and drugs predicts the drug adsorption process as favorable (Etotal = − 638.67 and − 259.80 kJ/mol for the Micelle@ANS and Micelle@MIC complexes, respectively). Our results offer a deep understanding of the micelle formation process, the electrical field-respond, and drug adsorption behaviors of the micelle. This simulation study has been accomplished by employing classical molecular dynamics calculation.

show abstract

“…The serious side effects of ANC drug include high blood pressure, hot flashes, unitability in circulation, etc. 10 , 11 .…”

Section: Introductionmentioning

confidence: 99%

Validation of an MD simulation approach for electrical field responsive micelles and their application in drug delivery

Razavi

Raissi

Farzad

2023

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Although these method has superior advantage according to exist method, it has some lacking. Thus, researchers go on to study new material and led to the find of several microextraction techniques [10]. As a result of the evaluation of different micro-extraction techniques, it was revealed that the deficiency in all these techniques was caused by the coating technology used for fixed the sorbent on the substrate surface and the physical format of the extraction systems determining PCSA [11].…”

Section: Introductionmentioning

confidence: 99%

Sensitive Determination of Venlafaxine in Urine Samples by Using HPLC-DAD System After Fabric Phase Sorptive Extraction

ÖZDEMİR

Ulusoy

Morgül

et al. 2022

Cumhuriyet Science Journal

Self Cite

View full text Add to dashboard Cite

This study is focused on developing a sensitive analytical method for Venlafaxine molecule which is antidepressant drug belonging to the serotonin-noradrenaline reuptake inhibitors (SNRI) group. With this study, a separation and preconcentration method based on fabric phase sorptive extraction(FPSE) method was developed for low levels of Venlafaxine in urine samples. Experimental variables such as pH, ionic strength, desorption solvent, and other parameters were studied and optimized step by step. The linearity of method under optimized conditions is in the range of 15.00-750.00 ng mL-1 while limit of detection is 4.28 ng mL-1. The relative standard deviation (RSD %) obtained from model solutions containing 300 ng mL-1 of Venlafaxine was lower than 3.1 % and pre-concentration factor was calculated as 62.50 for target molecule. In order to test accuracy of the method, recovery tests were carried out by means of spiked urine samples. As a result of recovery tests, quantative values were obtained in the range of 97.5-104.2 % successively.

show abstract

“…In addition, functionalized nanoparticles increase the stability of the sorbent because bare nanoparticles tend to accumulate and be oxidized when exposed to air [8][9][10]. Different compounds such as metal-organic frameworks, polymers, carbon-based nanoparticles, molecularly imprinted polymers [11,12], decanoic acid modified Fe 3 O 4 [13], carbon nanofiber-coated magnetic nanoparticles [14], and magnetic nanoparticles containing tetraethylenepentamine [15] have been prepared and utilized as selective and efficient sorbents. Despite significant successes in the improvement of coating properties, some drawbacks such as insufficient selectivity, thermal instability, lack of uniform formation of coatings, limited reusability, and strategies for growing the selected sorbent coating on the desired substrate are remaining.…”

mentioning

confidence: 99%

Magnetic solid‐phase extraction of warfarin and gemfibrozil in biological samples using polydopamine‐coated magnetic nanoparticles via core‐shell nanostructure

Ghani

Jafari

Maleki

et al. 2022

J of Separation Science

View full text Add to dashboard Cite

Herein, polydopamine-coated Fe 3 O 4 spheres were synthesized using a very simple, easy, cost-effective, efficient, and fast method. First, magnetic nanoparticles (Fe 3 O 4 ) were synthesized and were followed by accommodating polydopamine on the surface of the prepared Fe 3 O 4 . The prepared polydopamine-coated Fe 3 O 4 spheres were utilized as a sorbent in magnetic solid phase extraction of gemfibrozil and warfarin (as the model analytes). The extracted model analytes were desorbed by a suitable organic solvent and were analyzed by high-performance liquid chromatography. Under optimized condition, the linearity of the method was in the range of 0.1-200.0 μg/L for the selected analytes in water. The limits of detection were calculated to be in the range of 0.026-0.055 μg/L for warfarin and gemfibrozil, respectively. The limits of quantification were calculated to be in the range of 0.089-0.185 μg/L. The inter-day and intra-day relative standard deviations were determined to be in the range of 1.4%-3.3% in three concentrations in order to calculate the method precision. Furthermore, the enrichment factors were found to be 78 and 81 for warfarin and gemfibrozil, respectively. Moreover, the calculated absolute recoveries were between 78% and 81%. The obtained recoveries indicated that the method was useful and applicable in complicated real samples.

show abstract

Sensitive determination of Anastrozole and Letrozole in urine samples by novel magnetic nanoparticles containing tetraethylenepentamine (TEPA) prior to analysis by high-performance liquid chromatography-diode array detection

Cited by 6 publications

References 26 publications

Validation of an MD simulation approach for electrical field responsive micelles and their application in drug delivery

Validation of an MD simulation approach for electrical field responsive micelles and their application in drug delivery

Sensitive Determination of Venlafaxine in Urine Samples by Using HPLC-DAD System After Fabric Phase Sorptive Extraction

Magnetic solid‐phase extraction of warfarin and gemfibrozil in biological samples using polydopamine‐coated magnetic nanoparticles via core‐shell nanostructure

Contact Info

Product

Resources

About