Sensitive detection of esculetin based on a CdSe nanoparticles-decorated poly(diallyldimethylammonium chloride)-functionalized graphene nanocomposite film

Abstract

An electrochemical sensor based on a CdSe nanoparticles (NPs)-decorated poly(diallyldimethylammonium chloride) (PDDA)-functionalized graphene (CdSe-PDDA-G) nanocomposite was fabricated for the sensitive detection of esculetin. The nanocomposite was characterized by X-ray diffraction (XRD), ultraviolet/visible spectra (UV-vis) and transmission electron microscopy (TEM). Cyclic voltammetry (CV) and differential pulse voltammetry (DPV) were used to investigate the electrochemical behaviors of esculetin on the CdSe-PDDA-G composite film-modified glassy carbon electrode (GCE). The experimental results indicated that the incorporation of CdSe NPs with PDDA-G greatly enhanced the electrochemical response of esculetin. This electrochemical sensor displayed satisfactory analytical performance for esculetin detection over a range from 1.0 × 10(-8) to 5.0 × 10(-5) mol L(-1) with a detection limit of 4.0 × 10(-9) mol L(-1) (S/N = 3). Moreover, the sensor also exhibited good reproducibility and stability, and could be used for the detection of esculetin in real samples with satisfactory results.

Nanomaterials for bio-functionalized electrodes: recent trends

“…Recently, graphene-supported nanocomposites (Table 1) have shown fascinating advantages in electrochemistry for sensor development. [129][130][131][132][133][134][135][136][137][138][139][140][141][142][143][144][145][146][147] Graphene based enzyme biosensors have been reported in many publications which have been welldocumented in recent review articles. 33,37,[148][149][150][151][152] For example, a graphene-Au nanocomposite hybrid was synthesized by in situ growth of Au nanoparticles (AuNPs) on the surface of graphene nanosheets in the presence of poly(diallyldimethylammonium chloride) (PDDA), which improved the AuNPs dispersion and also stabilized cholinesterase with high activity and loading efficiency.…”

Sol–gel synthesis of palladium nanoparticles supported on reduced graphene oxide: an active electrocatalyst for hydrogen evolution reaction

“…17,18 Another example is CdSe NCs decorated graphene with promising properties for applications in photovoltaics. 9,[21][22][23] The hydrogen evolution reaction (HER) is an electrochemical process that has received wide attention because of its importance in both fundamental and technological electrochemistry such as fuel cell technology. [24][25][26][27] For development of the hydrogen-based fuel cell systems as power sources for emission-free electric vehicles, preparation of an active electrocatalyst is still the main subject.…”

Esculetin unveiled: Decoding its anti‐tumor potential through molecular mechanisms—A comprehensive review

“…According to the findings, esculetin can exhibit anti‐tumor activity after being loaded into PLGA nano‐micelles, and nano‐encapsulation increases its cytotoxic action in vitro with 92% encapsulation efficiency 90 . Lu et al stated that the electrochemical response of esculetin was significantly improved by the addition of CdSe NPs to PDDA‐G over a range from 1.0 × 10 −8 to 5.0 × 10 −5 mol L −1 with a detection limit of 4.0 × 10 −9 mol L −1 ( S / N = 3) 91 . Administration of esculetin with zinc oxide nanoparticles elevated caspase‐3 expression 92 .…”