Sensitive Detection of Acetaminophen with Graphene-Based Electrochemical Sensor

Detection of acetaminophen using cyclic voltammetry on MnFe2O4/polyaniline

“…This sensing material was characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM), and high-resolution transmission electron microscopy (HR-TEM). [2] Several methods have been employed to determine the concentration of acetaminophen, including capillary zone electrophoresis, [3] thermometric titration, [4] spectrofluorometry, [5] electrochemical analysis, [6][7][8][9] and high-performance liquid chromatography (HPLC). Furthermore, the sensor responses were 2.05-22.44.…”

“…However, overdose of acetaminophen harms the liver and kidneys. [6][7][8][9] Using HPLC for dissolution testing and analysis of acetaminophen resulted in the separation of three analytes and excipients within several minutes. [2] Several methods have been employed to determine the concentration of acetaminophen, including capillary zone electrophoresis, [3] thermometric titration, [4] spectrofluorometry, [5] electrochemical analysis, [6][7][8][9] and high-performance liquid chromatography (HPLC).…”

“…[2] Several methods have been employed to determine the concentration of acetaminophen, including capillary zone electrophoresis, [3] thermometric titration, [4] spectrofluorometry, [5] electrochemical analysis, [6][7][8][9] and high-performance liquid chromatography (HPLC). [6][7][8][9] Several sensing materials have been used to measure the acetaminophen concentration in electrochemical analysis. In addition, it satisfactorily achieves separation between paminophenol and acetaminophen.…”

“…[10] A migration behavior can be discerned, and quantification of acetaminophen concentration can be achieved through capillary zone electrophoresis, which has a sensitivity of detection of 4.2 ng/mL. [7][8][9] Single-walled carbon nanotube graphene nanosheet hybrid films modified using a GCE exhibited substantial linearity from 0.05 × 10 −6 to 64.5 × 10 −6 M. [7] A Y 2 O 3 NPs/CNTs/ GCE demonstrated a lower DL of 3.0 × 10 −11 M for determining the acetaminophen concentration; this GCE did not interfere with ascorbic acid and tyrosine. [3] Thermometric titration can be used to determine acetaminophen concentration, which is ≧75 mg in pure or medicinal form; the excipient test for starch, talc, or lactose does not affect the accuracy.…”

“…[3] Thermometric titration can be used to determine acetaminophen concentration, which is ≧75 mg in pure or medicinal form; the excipient test for starch, talc, or lactose does not affect the accuracy. [9] Polyaniline (PANI) is a conducting polymer and it exhibits high electrical conductivity. [5] A cuprous oxide nanoparticle-graphene nanocomposite was used to modify a glassy carbon electrode (GCE); a detection limit (DL) of 6.67 × 10 −9 M was obtained for concentrations from 2.0 × 10 −8 to 1.3 × 10 −6 M and a sensitivity of 14,397.7 μA/mM through electrochemical analysis was obtained.…”