Sensitive detection of a pseudo-polyrotaxane ultrathin film by SPR and QCM-D methods

Tawa, Keiko; Kuboyama, Norihito; Ahmed, Saleh; Tanaka, Mutsuo; Nakaoki, Takahiko

doi:10.1016/j.snb.2009.01.068

Cited by 9 publications

(8 citation statements)

References 34 publications

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“…However, when more numbers of CDs are threaded onto a PEG chain, the space for the movement of CDs is restricted leading to low molecular mobility [19]. This molecular mobility or the mobility factor has been quantified using methods such as wet and dry contact angle measurements and quartz crystal microbalance dissipation (QCM-D) studies [20,21]. Furthermore, some researchers have shown that these CD rings can also be crosslinked to act like pulleys for the polymeric chains, which leads to the formation of very highly stretchable biomaterials [22].…”

Section: Polyrotaxanes and Molecular Mobilitymentioning

confidence: 99%

Polyrotaxanes as emerging biomaterials for tissue engineering applications: a brief review

et al. 2020

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The field of tissue engineering and regeneration constantly explores the possibility of utilizing various biomaterials’ properties to achieve effective and uneventful tissue repairs. Polyrotaxanes (PRXs) are supramolecular assemblies, which possess interesting mechanical property at a molecular scale termed as molecular mobility. This molecular mobility could be utilized to stimulate various cellular mechanosignaling elements, thereby altering the cellular functions. Apart from this, the versatile nature of PRXs such as the ability to form complex with growth factors and peptides, numerous sites for chemical modifications, and processability into different forms makes them interesting candidates for applications towards tissue engineering. This literature briefly reviews the concepts of PRXs and molecular mobility, the versatile nature of PRXs, and its emerging utility towards certain tissue engineering applications.

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Section: Polyrotaxanes and Molecular Mobilitymentioning

confidence: 99%

Polyrotaxanes as emerging biomaterials for tissue engineering applications: a brief review

et al. 2020

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“…Chemical structure of biocleavable polyrotaxane nanoassemblies (a) cationic polyrotaxane, (b) polyelectrolyte complex of the polyrotaxane with plasmid DNA, (c) scission of stopper groups by enzymes within the cell, and (d) dissociation of the nanoparticle, liberation of the pDNA. 83 monolayers on gold, [85][86][87] shape-control of polymers by dendritic side groups, 88 nanorod formation of peptides, 89 and biotin-streptavidin recognition 90 to construct sophisticated functional molecular architectures in solution, at liquid-liquid interfaces or at solid surfaces. This study is just a beginning, and there is still plenty of opportunity to explore.…”

Section: Possible Applications Of CD Polyrotaxanes In the Futurementioning

confidence: 99%

“…Therefore, they will be useful in products with high value, including analytic kits, diagnostics systems, drug delivery systems, gene delivery systems, and other bio-or nanotechnologies. The self-organization of CDs and polymers into polyrotaxanes can be combined with other types of self-organization, such as layer-by-layer assembly, 84 self-assembly of thiol 83 monolayers on gold, [85][86][87] shape-control of polymers by dendritic side groups, 88 nanorod formation of peptides, 89 and biotin-streptavidin recognition 90 to construct sophisticated functional molecular architectures in solution, at liquid-liquid interfaces or at solid surfaces. This study is just a beginning, and there is still plenty of opportunity to explore.…”

Section: Possible Applications Of CD Polyrotaxanes In the Futurementioning

confidence: 99%

Cyclodextrin polyrotaxanes assembled from a molecular construction kit in aqueous solution

Wenz

2009

J. Polym. Sci. A Polym. Chem.

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ABSTRACT:We describe a molecular construction kit in which amphiphilic polymers and functionalized cyclodextrins are arranged into sophisticated molecular architectures in aqueous solution without the need to perform chemical reactions. Therefore, these systems are highly biocompatible and show programmable lifetimes. The kinetic stabilities of our polyrotaxane structures are tunable using sterically demanding groups that hinder dissociation. These cyclodextrinbased polymer systems are applicable in principle for the detection of analytes at the level of single molecules. These systems may also serve well in targeted drug delivery and gene transfection.

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“…XRR is a scattering based technique allowing the layer thickness, density and surface roughness to be accurately determined ( 12 – 14 ). QCM-D experiment is capable of determining mass changes with a sensitivity of ngcm −2 as it was proven in several publications ( 15 , 16 ). Furthermore changes in the dissipative responds of the crystal on film changes (mass change, swelling, …) allow interactions to be elucidated ( 17 , 18 ).…”

Section: Introductionmentioning

confidence: 96%

Dissolution Testing of Hardly Soluble Materials by Surface Sensitive Techniques: Clotrimazole from an Insoluble Matrix

et al. 2014

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PurposeThe low aqueous solubility of many drugs impedes detailed investigation as the detection limit of standard testing routines is limited. This is further complicated within application relevant thin films typical used in patches or stripes for buccal or topical routes.MethodsIn this work a model system is developed based on spin – casting technique allowing defined clotrimazole and clotrimazole – polystyrene composite films preparation at a solid surface. Various highly sensitive techniques including quarz crystal microbalance (QCM), X-ray reflevtivity (XRR) and X-ray photon spectroscopy (XPS) are used to investigate the drug release over time into an aqueous media.ResultsThe results reveal a steady drug release for both samples over the course of the experiments but with the release from the composite being significantly slower. In addition the dissolution rate of the clotrimazole sample initially increases up to 30 min after which a decrease is noted. XRR shows that this is a result of surface roughening together with film thickness reduction. The results for the composite show that the release in the composite film is a result of drug diffusion within the matrix and collapsing PS film thickness whereby XPS shows that the amount of clotrimazole at the surface after 800 min immersion is still high.ConclusionIt can be stated that the applied techniques allow following low mass drug release in detail which may also be applied to other systems like pellets or surface loaded nano-carriers providing information for processing and application relevant parameters.

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Sensitive detection of a pseudo-polyrotaxane ultrathin film by SPR and QCM-D methods

Cited by 9 publications

References 34 publications

Polyrotaxanes as emerging biomaterials for tissue engineering applications: a brief review

Polyrotaxanes as emerging biomaterials for tissue engineering applications: a brief review

Cyclodextrin polyrotaxanes assembled from a molecular construction kit in aqueous solution

Dissolution Testing of Hardly Soluble Materials by Surface Sensitive Techniques: Clotrimazole from an Insoluble Matrix

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