Cyclodextrin polyrotaxanes assembled from a molecular construction kit in aqueous solution

Abstract

ABSTRACT:We describe a molecular construction kit in which amphiphilic polymers and functionalized cyclodextrins are arranged into sophisticated molecular architectures in aqueous solution without the need to perform chemical reactions. Therefore, these systems are highly biocompatible and show programmable lifetimes. The kinetic stabilities of our polyrotaxane structures are tunable using sterically demanding groups that hinder dissociation. These cyclodextrinbased polymer systems are applicable in principle for the detection of analytes at the level of single molecules. These systems may also serve well in targeted drug delivery and gene transfection.

Synthesis, Photophysical, and Morphological Properties of Azomethine‐Persylilated α‐Cyclodextrin Main‐Chain Polyrotaxane

“…[11][12][13][14][15][16][17][18][19][20] The encapsulation into macrocyclic cavities, i.e., native cyclodextrins (CDs) of PAMs present noticeable advantages for optoelectronic applications, compared to those observed on nonrotaxane counterparts, due to easier processability and adhesivity on the substrates of solid fi lms, as well as the improvements of morphological characteristics. [ 16,17,19,21,22 ] The use of permodifi ed CDs derivatives, which exhibit higher solubility in nonpolar organic solvents and lower propensity to aggregate formations [ 23,24 ] has been employed as an alternative supramolecular approach for the synthesis of polyrotaxanes with conjugated polymers. [25][26][27][28][29][30] Recently, permethylated αCD has been shown to produce PAMs main-chain polyrotaxanes with better solubility in common organic solvents and easier processability with respect to the nonrotaxane ones.…”

Synthesis of a resin monomer-soluble polyrotaxane crosslinker containing cleavable end groups

“…Generally, PRX derivatives show poor solubility in various organic solvents, including liquid resin monomers, due to a large number of hydroxy groups on α-CDs [ 20 ]. Therefore, research work has been conducted to enhance the solubility of the PRX-based materials in a variety of solvents [ 21 – 23 ]. In the present study, PRX derivatives soluble in resin monomers, i.e., a mixture of HEMA and UDMA, were synthesized.…”

Synthesis of the anionic hydroxypropyl-β-cyclodextrin:poly(decamethylenephosphate) polyrotaxane and evaluation of its cholesterol efflux potential in Niemann–Pick C1 cells

“…The kinetics followed a stretched exponential time law (Equation 1) as is typical for one-dimensional diffusion. 60,61 The occupancy y approaches a limiting value of y ∞ = 48. (1)…”