Sensitive Bromatometric Methods for the Determination of Sumatriptan Succinate in Pharmaceutical Formulations

Kosaraju, Satyanarayana; Rao, P. Nageswara

doi:10.1155/2011/562749

Cited by 5 publications

(4 citation statements)

References 12 publications

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“…1) is a selective serotonin (5-HT1) agonist and commonly utilized for the remediation of severe headache period of migraine symptoms [1] . Different procedures were reported for the estimation of STS in different matrices such as spectro uorimetry [2] , spectrophotometry [3][4][5][6][7][8] , HPLC [9][10][11][12][13][14] and thin-layer chromatography [15][16][17] . The current work pursued to promote and validate a straightforward, fast, sensitive, and speci c spectro uorimetric method for the estimation of STS, using its inherent uorescence of its methanolic solution at acidic pH.…”

Section: Introductionmentioning

confidence: 99%

Novel fluorimetric procedure for estimation of Sumatriptan in its tablet formulation and in human plasma; Implementation to content symmetry testing

Alrofaidi,

Omar,

Abdelmageed

et al. 2023

Preprint

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A rapid, simple & specific fluorimetric method has been described for estimation of Sumatriptan succinate in its pharmaceutical preparation and in human plasma. The proposed procedure is based on the measurement of the fluorescence intensity of studied drug in sulphuric acid / methanol at 350 nm (λex 286 nm). Straight correlation was obtained between the fluorescence intensity and concentrations studied over the concentration range 0.1 -2.0 µg/ml with correlation coefficient of 0.999. The detection and quantitation limits were 0.019 and 0.057 µg/ml, respectively. The suggested procedure was validated according to ICH and USP guidelines. It was applied successfully implemented to the estimation of STS in its tablet formulation and content uniformity testing. The suggested method was sensitive enough to allow the estimation of STS in human plasma.

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Section: Introductionmentioning

confidence: 99%

Novel fluorimetric procedure for estimation of Sumatriptan in its tablet formulation and in human plasma; Implementation to content symmetry testing

Alrofaidi,

Omar,

Abdelmageed

et al. 2023

Preprint

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“…Based on a well-known redox reaction and employing Folin-Ciocalteu's reagent [35], the drug in pharmaceutical dosage forms was determined by Tipre and Vivia. Satyanarayana and Rao [36] have described two methods using the reaction between drug and in situ bromine and the unreacted bromine measured either by methyl orange or indigo carmine. …”

Section: Introductionmentioning

confidence: 99%

Utilization ofN-Bromosuccinimide as a Brominating Agent for the Determination of Sumatriptan Succinate in Bulk Drug and Tablets

Prashanth

Basavaiah

Raghu

2013

International Journal of Analytical Chemistry

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One titrimetric and two spectrophotometric methods which are simple, sensitive, and economic are described for the determination of sumatriptan succinate (STS) in bulk drug and in tablet dosage form using N-bromosuccinimide (NBS) as a brominating agent. In titrimetry, aqueous solution of STS is treated with a measured excess of NBS in acetic acid medium, and after the bromination of STS is judged to be complete, the unreacted NBS is determined iodometrically (method A). Spectrophotometric methods entail addition of a known excess of NBS in acid medium followed by the determination of residual NBS by its reaction with excess iodide, and the liberated iodine (I3 −) is either measured at 370 nm (method B) or liberated iodine is reacted with starch followed by the measurement of the blue colored starch-iodine complex at 570 nm (method C). Titrimetric method is applicable over range 1.0–10.0 mg STS (method A), and the reaction stoichiometry is found to be 1 : 3 (STS : NBS). The spectrophotometric methods obey Beer's law for concentration range 0.6–15.0 μg mL−1 (method B) and 0.2–4.0 μg mL−1 (method C). The calculated apparent molar absorptivity values were found to be 2.10 × 104 and 7.44 × 104 L mol−1 cm−1, for method B and method C, respectively.

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“…Besides, SMT in pharmaceuticals is reported to have been determined by visible spectrophotometry employing different reaction schemes. Satyanarayana and Rao [28] have described two methods using in situ bromine, methyl orange, and indigo carmine as reagents. Based on a wellknown redox reaction and employing Folin-Ciocalteu's reagent [22], the drug in pharmaceutical dosage forms was determined byTipre and Vavia .…”

Section: Introductionmentioning

confidence: 99%

Use of Charge Transfer Complexation Reactions for the Spectrophotometric Determination of Sumatriptan in Pharmaceuticals

et al. 2012

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Studies were carried out to use the charge-transfer reactions of sumatriptan (SMT), extracted from neutralized sumatriptan succinate (STS), as n-electron donor with the π-acceptor, 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and σ-acceptor, and iodine (I2). The formation of the colored complexes was utilized for the development of simple, rapid, and accurate spectrophotometric methods for the determination of SMT in pure form as well as in its tablets. The quantification of colored products was made spectrophotometrically at 585 nm for the CT complex formed between SMT and DDQ (DDQ method) and at 375 nm for the CT complex formed between SMT and I2 (I2 method). Beer’s law is obeyed over the concentration ranges of 4.0–56.0 μg mL−1 and 2.0–28.0 for DDQ and I2, respectively, with correlation coefficients () of 0.9997 and 0.9998. The analytical parameters such as apparent molar absorptivity, Sandell’s sensitivities, and limits of detection (LOD) and quantification (LOQ) are also reported for both methods. The described methods were successfully applied to the determination of SMT in tablets. No interference was observed from the common excipients present in tablets. The reaction stoichiometry in both methods was evaluated by Job’s method of continuous variations and was found to be 1 : 1 (donor : acceptor).

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Sensitive Bromatometric Methods for the Determination of Sumatriptan Succinate in Pharmaceutical Formulations

Cited by 5 publications

References 12 publications

Novel fluorimetric procedure for estimation of Sumatriptan in its tablet formulation and in human plasma; Implementation to content symmetry testing

Novel fluorimetric procedure for estimation of Sumatriptan in its tablet formulation and in human plasma; Implementation to content symmetry testing

Utilization ofN-Bromosuccinimide as a Brominating Agent for the Determination of Sumatriptan Succinate in Bulk Drug and Tablets

Use of Charge Transfer Complexation Reactions for the Spectrophotometric Determination of Sumatriptan in Pharmaceuticals

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