Utilization ofN-Bromosuccinimide as a Brominating Agent for the Determination of Sumatriptan Succinate in Bulk Drug and Tablets

Abstract

One titrimetric and two spectrophotometric methods which are simple, sensitive, and economic are described for the determination of sumatriptan succinate (STS) in bulk drug and in tablet dosage form using N-bromosuccinimide (NBS) as a brominating agent. In titrimetry, aqueous solution of STS is treated with a measured excess of NBS in acetic acid medium, and after the bromination of STS is judged to be complete, the unreacted NBS is determined iodometrically (method A). Spectrophotometric methods entail addition of a known excess of NBS in acid medium followed by the determination of residual NBS by its reaction with excess iodide, and the liberated iodine (I3 −) is either measured at 370 nm (method B) or liberated iodine is reacted with starch followed by the measurement of the blue colored starch-iodine complex at 570 nm (method C). Titrimetric method is applicable over range 1.0–10.0 mg STS (method A), and the reaction stoichiometry is found to be 1 : 3 (STS : NBS). The spectrophotometric methods obey Beer's law for concentration range 0.6–15.0 μg mL−1 (method B) and 0.2–4.0 μg mL−1 (method C). The calculated apparent molar absorptivity values were found to be 2.10 × 104 and 7.44 × 104 L mol−1 cm−1, for method B and method C, respectively.

New Smartphone based Colorimetric Method Development and validation for the Drugs containing Nitrogen, Sulphur and Phosphorus in Bulk and Tablet Dosage Form

“…Triptans' potential mechanisms of action in migraine include cerebral vasoconstriction, decrease of neuropeptide and protein extravasation across dural arteries, and central inhibition of impulse transmission within the trigeminovascular system. 7,8 Triptans' major function in migraine, in our opinion, is to constrict dilated cranial extracerebral blood arteries, which is a 5-HT1B impact. When pure 5-HT1D receptor agonists have been produced and tested for efficacy in migraine, the potential contribution of triptans' neuronal impact can be assessed.…”

Determination of cefdinir in pharmaceutical preparations by oxidative conjugation method

“…Effect of reagent concentration: To observe how increasing amounts of reagent para-aminobenzoic acid at a concentration of 0.01 M, influenced uptake, the largest supplied volume of the reagent was 1 ml, as shown in figure (3): Effect of the use the bases different: Determine which base has the best absorption while forming the product, the bases (NaOH, NH4OH, and KOH) were employed with a concentration of 1.0M for each, as well as the same volume of 0.5ml, (table 1) reveals that the best base to produce the product is sodium hydroxide [21,22]. Effect of base volume: The volume that delivers the maximum absorption was determined by adding increasing volumes of NaOH at a concentration of 1.0 molar, with the optimal volume added from the base being 0.5 m [23][24][25][26], is shown in (Fig. 4).…”

Spectrophotometric Determination of Alzheimer’s Drug, Memantine Hydrochloride in Biological Samples Using Ninhydrin and Ferric Chloride

“…When reacting with these free amines, a deep blue or purple color known as Ruhemann's purple is evolved [24,25]. Ninhydrin is known to yield a complex, which are applied in the determination of many pharmaceutical compounds [26][27][28][29][30][31][32][33][34].…”