Sensitive and selective voltammetric determination of anti˗cancer agent shikonin on sepiolite clay/TiO 2 nanoparticle/MWCNTs composite carbon paste sensor and investigation of its electro˗oxidation mechanism

Bayraktepe, Dilek Eskiköy; Yazan, Zehra; Polat, Kamran

doi:10.1016/j.jelechem.2016.08.035

Cited by 35 publications

(14 citation statements)

References 28 publications

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“…The slopes of −0.055, −0.046 and −0.042 V/pH are close to the theoretical Nernstian value of 0.059 V/pH . According to the Nernstian equation, the results showed that the number of protons and electrons are equal in the redox oxidation mechanism of PAR, A and ASA.…”

Section: Resultssupporting

confidence: 80%

“…As indicated in the insets of Figure , with increasing pH values the peak potentials of all compounds shift to more negative values. This phenomenon indicated that the oxidation reactions of PAR, A and ASA were accompanied by proton transfer . The relation between the anodic peak potentials, Ep and pH is as follows:

true E p_{(normalA)} = - 0.055 p H + 0.3612 (R^{2} = 0.8741)

true E p_{(PAR)} = - 0.046 p H + 0.7095 (R^{2} = 0.9695)

true E p_{(ASA)} = - 0 . 042 p H + 1.1249 (R^{2} = 0.9759)

…”

Section: Resultsmentioning

confidence: 94%

“…The SEP/MWCNTs/pPGE composite electrode may be attributed to the fact that the pretreatment and modifiers added caused the surface area of the pencil graphite electrode to increase . The active surface areas of five electrodes were calculated in 5.0 mM Fe(CN) 6 3−/4− in 0.1 M KCl using the Randles‐Sevcik equation . This quantity for SEP/MWCNTs/pPGE composite (0.814 cm 2 ) was found to be the greatest compared to the other electrodes (PGE: 0.393; pPGE: 0.458; chit/pPGE: 0.720; MWCNTs/pPGE: 0.714; SEP/pPGE: 0.780 cm 2 ).…”

Section: Resultsmentioning

confidence: 99%

“…Cyclic voltammetry is known as an important tool to investigate the electrochemical behavior of various compounds and possible surface activity . For this reason, we have studied the electrochemical performance of unmodified and four modified electrodes including bare (PGE), pretreated PGE (pPGE), Chit/pPGE, SEP/pPGE and SEP/MWCNTs/pPGE.…”

Section: Resultsmentioning

confidence: 99%

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Application of Single‐use Electrode Based on Nano‐clay and MWCNT for Simultaneous Determination of Acetaminophen, Ascorbic Acid and Acetylsalicylic Acid in Pharmaceutical Dosage

Bayraktepe

Yazan

2020

Electroanalysis

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In this study, a highly sensitive, selective and cost‐effective electrochemical nano‐sensor has been developed for the first time so as to facilitate the simultaneous and low‐level detection of acetaminophen (paracetamol, PAR), ascorbic acid (A) and acetylsalicylic acid (ASA) ternary mixture. The sensor is based on nano‐sepiolite clay (SEP) with multiwall carbon nanotubes (MWCNTs) onto electrochemically pretreated pencil graphite electrode (pPGE). The surface properties of the sensor were examined by using cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and scanning electron microscopy (SEM) techniques. The pH effect, composition of modifiers, immobilization time, deposition potential and deposition time values were optimized to reach the best response of PAR, A and ASA. Moreover, in optimum analytical conditions, adsorptive stripping differential pulse voltammmetric (AdsDPV) method was developed for the simultaneous analysis of the ternary mixtures concerned by using SEP/MWCNTs/pPGE sensor. This sensor exhibited the low detection limits of 0.018, 0.042 and 0.047 μM for PAR, A and ASA ternary mixture, respectively. The developed AdsDPV method was applied for quantitative determination of PAR, A and ASA in the pharmaceutical formulation. The recovery experiments were carried out to control the accuracy and precision of the method. The obtained voltammetric recoveries were comparable with the HPLC data given in the literature.

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Section: Resultssupporting

confidence: 80%

true E p_{(normalA)} = - 0.055 p H + 0.3612 (R^{2} = 0.8741)

true E p_{(PAR)} = - 0.046 p H + 0.7095 (R^{2} = 0.9695)

true E p_{(ASA)} = - 0 . 042 p H + 1.1249 (R^{2} = 0.9759)

…”

Section: Resultsmentioning

confidence: 94%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Application of Single‐use Electrode Based on Nano‐clay and MWCNT for Simultaneous Determination of Acetaminophen, Ascorbic Acid and Acetylsalicylic Acid in Pharmaceutical Dosage

Bayraktepe

Yazan

2020

Electroanalysis

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“…Dönüşümlü voltametri yöntemi (CV), birçok türün elektrokimyasal davranışının incelenmesinde büyük önem taşımaktadır. Bunun yanı sıra, bazı redoks probları yardımıyla modifiye edilmiş elektrot yüzeylerinin incelenmesinde de DV yöntemi sıklıkla başvurulan bir yöntemdir [27] Şekil 5a"ya; her iki katyon için en yüksek pik akımları biriktirme potansiyeli değeri -1,5 V"da elde edilmiş olup biriktirme potansiyeli arttırıldıkça akımlarda düşüş olduğu görülmüştür. Bu bilgiler ışığında, en uygun biriktirme potansiyeli her iki katyon için de -1,5 V olarak belirlenmiştir.…”

Section: A Elektrot Karakteri̇zasyonuunclassified

NiO Modifiye Karbon Pasta Sensör Yüzeyinde Bakır ve Kadmiyum’un Anodik Sıyırma Voltametrisi ile Tayini

Yıldız

Bayraktepe

Yazan

2019

Düzce Üniversitesi Bilim Ve Teknoloji Dergisi

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Bu çalışmada NiO nanopartiküllerine dayanan, hızlı, duyarlı, düşük maliyetli yeni bir karbon pasta elektrot geliştirilmesi ve bu elektrodun differansiyel puls anodik sıyırma voltametrisi (DPASV) yöntemiyle musluk suyunda bulunan Cu 2+ ve Cd 2+ "un analizinde kullanılması amaçlanmıştır. Bu amaç doğrultusunda, çıplak karbon pasta elektrot (KPE) ve NiO nanopartikülleriyle modifiye edilmiş olan karbon pasta elektrot (NiO/KPE) yüzeyleri EIS ve CV yöntemiyle yapılan karakterizasyon yöntemleri ile karşılaştırılmıştır. Elde edilen sonuçlar, NiO/KPE"un elektroaktif türlere karşı elektrokatalitik etkisinin olduğunu göstermiş ve NiO/KPE, Cu 2+ ve Cd 2+ "un voltametrik analizinde çalışma elektrodu olarak kullanılmıştır. Çalışma elektrodunun belirlenmesinin ardından, bazı analitik ve yöntem parametrelerinin optimizasyonu yapılmış olup, her iki katyon için; optimum NiO bileşimi 3,0 mg NiO/30 mg pasta, optimum pH BR tampon ortamında 3,0, optimum biriktirme potansiyeli-1,5 V ve optimum biriktirme süresi ise 180,0 s olarak belirlenmiştir. Belirlenmiş olan optimum koşullarda, bir katyonun derişimi sabit tutulup, diğerinin derişimi arttırılarak ve her iki katyonun da derişimi arttırılarak kalibrasyon eğrileri oluşturulmuştur. Kalibrasyon eğrilerinden elde edilen veriler yardımıyla bulunan alt tayin sınırı ve doğrusal çalışma aralıkları her bir katyon için hesaplanmıştır. Yöntemin uygulanabilirliğinin test edilmesi amacıyla, musluk suyu içeren ortamda da Cu 2+ ve Cd 2+ "un analizi yeni geliştirilmiş olan DPASV yöntemiyle yapılmış ve geri kazanı değerleri %100 civarında bulunmuştur.

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Simultaneous Trace Electrochemical Determination of Xanthine Theophylline and Theobromine with a Novel Sensor Based on a Composite Including Metal Oxide Nanoparticle Multi‐walled Carbon Nanotube and Nano‐Na‐montmorillonite Clay

2021

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We report the simultaneous determination of purine molecules with biological significance on pencil graphite electrode (PGE) modified with a composite solution including NiO nanoparticles, multi-walled carbon nanotube (MWCNT), and natural nano-Na-montmorillonite clay (NNaM) using DPV technique. The novel sensor, NiO/MWCNT/NNaM/PGE, achieved simultane-ous determination of xanthine, theophylline, and theobromine at the detection limits 0.077 μM, 0.361 μM, and 0.458 μM with the linear working ranges 0.5-150 μM, 5-200 μM, and 5-250 μM in Britton-Robinson buffer at pH 2.0, respectively. The sensor revealed excellent performance for the simultaneous determination of XT, TP, and TB in three real-world samples.

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Sensitive and selective voltammetric determination of anti˗cancer agent shikonin on sepiolite clay/TiO 2 nanoparticle/MWCNTs composite carbon paste sensor and investigation of its electro˗oxidation mechanism

Cited by 35 publications

References 28 publications

Application of Single‐use Electrode Based on Nano‐clay and MWCNT for Simultaneous Determination of Acetaminophen, Ascorbic Acid and Acetylsalicylic Acid in Pharmaceutical Dosage

Application of Single‐use Electrode Based on Nano‐clay and MWCNT for Simultaneous Determination of Acetaminophen, Ascorbic Acid and Acetylsalicylic Acid in Pharmaceutical Dosage

NiO Modifiye Karbon Pasta Sensör Yüzeyinde Bakır ve Kadmiyum’un Anodik Sıyırma Voltametrisi ile Tayini

Simultaneous Trace Electrochemical Determination of Xanthine Theophylline and Theobromine with a Novel Sensor Based on a Composite Including Metal Oxide Nanoparticle Multi‐walled Carbon Nanotube and Nano‐Na‐montmorillonite Clay

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