Sensitive and selective determination of bromisovalum by high-performance liquid chromatography/particle beam mass spectrometry

Nagata, Takeaki; Kudo, Kazuhiko; Imamura, Tohru; Jitsufuchi, Narumi

doi:10.1016/0379-0738(95)01762-8

Cited by 9 publications

(3 citation statements)

References 11 publications

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“…HPLC/DAD and capillary GC/ MS were employed to quantify dothiepin in biological fluids, tissues, and hair from a death attributed to oral dothiepin ingestion (363). A specific procedure using HPLC/particle beam MS has facilitated the determination of bromisovalum in human plasma and whole blood (364). Antihistamine concentrations have been determined in postmortem blood and liver specimens (365).…”

Section: Drugs and Poisonsmentioning

confidence: 99%

Forensic Science

Brettell¹,

Saferstein²

1997

Anal. Chem.

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Section: Drugs and Poisonsmentioning

confidence: 99%

Forensic Science

Brettell¹,

Saferstein²

1997

Anal. Chem.

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“…The present method allows for the determination of bromvalerylurea concentrations as low as 1 mg/ml, which is superior to the LC/MS method of Higuchi et al, 13) which has a lower detection limit of 10 mg/ml. Among the blood concentrations reported in acute poisoning victims, Maguchi 19) reported that the concentration of bromides in body fluid in acute intoxication ranged from 20 to 50 mg/ml, indicating that the bromvalerylurea concentration in the blood was in the range of 55.8-140 mg/ml, whereas Nagata et al 12) found a blood level of bromvalerylurea of 2.31 mg/ml, which is sufficiently high to require treatment, in a patient who died after ingesting it. This suggests the need to measure the compound at a blood concentration range of less than 10 mg/ml for the treatment of bromvalerylurea poisoning.…”

Section: Calibration Curvesmentioning

confidence: 99%

“…LC/MS methods of analysis for salicylic acid, 6) acetaminophen, [6][7][8] theophylline, 9,10) barbiturates, 11) and bromvalerylurea [12][13][14] have been reported, but our examination of the literature has not revealed any method of simultaneous analysis for all of these from biological samples.…”

mentioning

confidence: 96%

Method for Screening and Quantitative Determination of Serum Levels of Salicylic Acid, Acetaminophen, Theophylline, Phenobarbital, Bromvalerylurea, Pentobarbital, and Amobarbital Using Liquid Chromatography/Electrospray Mass Spectrometry

Hori

Fujisawa

Shimada

et al. 2006

Biological & Pharmaceutical Bulletin

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Liquid chromatography?mass spectrometry in forensic toxicology

Bocxlaer¹,

Clauwaert²,

Lambert³

et al. 2000

Mass Spectrom. Rev.

115

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Liquid chromatography—mass spectrometry has evolved from a topic of mainly research interest into a routinely usable tool in various application fields. With the advent of new ionization approaches, especially atmospheric pressure, the technique has established itself firmly in many areas of research. Although many applications prove that LC—MS is a valuable complementary analytical tool to GC—MS and has the potential to largely extend the application field of mass spectrometry to hitherto “MS‐phobic” molecules, we must recognize that the use of LC—MS in forensic toxicology remains relatively rare. This rarity is all the more surprising because forensic toxicologists find themselves often confronted with the daunting task of actually searching for evidence materials on a scientific basis without any indication of the direction in which to search. Through the years, mass spectrometry, mainly in the GC—MS form, has gained a leading role in the way such quandaries are tackled. The advent of robust, bioanalytically compatible combinations of liquid chromatographic separation with mass spectrometric detection really opens new perspectives in terms of mass spectrometric identification of difficult molecules (e.g., polar metabolites) or biopolymers with toxicological relevance, high throughput, and versatility. Of course, analytical toxicologists are generally mass spectrometry users rather than mass spectrometrists, and this difference certainly explains the slow start of LC—MS in this field. Nevertheless, some valuable applications have been published, and it seems that the introduction of the more universal atmospheric pressure ionization interfaces really has boosted interests. This review presents an overview of what has been realized in forensic toxicological LC—MS. After a short introduction into LC—MS interfacing operational characteristics (or limitations), it covers applications that range from illicit drugs to often abused prescription medicines and some natural poisons. As such, we hope it can act as an appetizer to those involved in forensic toxicology but still hesitating to invest in LC—MS. © 2000 John Wiley & Sons, Inc., Mass Spec Rev 19: 165–214, 2000

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Sensitive and selective determination of bromisovalum by high-performance liquid chromatography/particle beam mass spectrometry

Cited by 9 publications

References 11 publications

Forensic Science

Forensic Science

Method for Screening and Quantitative Determination of Serum Levels of Salicylic Acid, Acetaminophen, Theophylline, Phenobarbital, Bromvalerylurea, Pentobarbital, and Amobarbital Using Liquid Chromatography/Electrospray Mass Spectrometry

Liquid chromatography?mass spectrometry in forensic toxicology

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