Sensitive and selective determination of dopamine by electrochemical sensor based on molecularly imprinted electropolymerization of o-phenylenediamine

Wu, Dan; Li, He; Xue, Xiaodong; Fan, Haixia; Xin, Qiang; Wei, Qin

doi:10.1039/c3ay26200f

Cited by 39 publications

(17 citation statements)

References 23 publications

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“…Moreover, the imprinted polymer effectively avoided the interferences caused by ascorbic acid and uric acid, which coexist with dopamine in biological samples. In another work, a gold electrode was modified by biocompatible sulfonated graphene and by a dopamine-imprinted film polymerized in the presence of conducting o-phenylenediamine monomer [165]. This biosensor allowed the detection of dopamine in the range of 3-50 µM, and the low detection limit was 0.7 µM.…”

Section: Molecularly Imprinted Polymersmentioning

confidence: 99%

Electrochemical Biosensing of Dopamine Neurotransmitter: A Review

2021

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Neurotransmitters are biochemical molecules that transmit a signal from a neuron across the synapse to a target cell, thus being essential to the function of the central and peripheral nervous system. Dopamine is one of the most important catecholamine neurotransmitters since it is involved in many functions of the human central nervous system, including motor control, reward, or reinforcement. It is of utmost importance to quantify the amount of dopamine since abnormal levels can cause a variety of medical and behavioral problems. For instance, Parkinson’s disease is partially caused by the death of dopamine-secreting neurons. To date, various methods have been developed to measure dopamine levels, and electrochemical biosensing seems to be the most viable due to its robustness, selectivity, sensitivity, and the possibility to achieve real-time measurements. Even if the electrochemical detection is not facile due to the presence of electroactive interfering species with similar redox potentials in real biological samples, numerous strategies have been employed to resolve this issue. The objective of this paper is to review the materials (metals and metal oxides, carbon materials, polymers) that are frequently used for the electrochemical biosensing of dopamine and point out their respective advantages and drawbacks. Different types of dopamine biosensors, including (micro)electrodes, biosensing platforms, or field-effect transistors, are also described.

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Section: Molecularly Imprinted Polymersmentioning

confidence: 99%

Electrochemical Biosensing of Dopamine Neurotransmitter: A Review

2021

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“…In NTs detection, non-conductive polymers also have been used to develop sensors due to their insulating properties that reduce the EC signal resulting from other biological interferences. This in turn improves the selectivity of the sensors [200]. However, the electrode modification is necessary because the bare electrode cannot distinguish between DA and other biological samples due to the overlapping of their signals.…”

Section: Polymer-based Ec Sensormentioning

confidence: 99%

Recent Advances in Electrochemical and Optical Sensing of Dopamine

Eddin

Fen

2020

Sensors

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Nowadays, several neurological disorders and neurocrine tumours are associated with dopamine (DA) concentrations in various biological fluids. Highly accurate and ultrasensitive detection of DA levels in different biological samples in real-time can change and improve the quality of a patient’s life in addition to reducing the treatment cost. Therefore, the design and development of diagnostic tool for in vivo and in vitro monitoring of DA is of considerable clinical and pharmacological importance. In recent decades, a large number of techniques have been established for DA detection, including chromatography coupled to mass spectrometry, spectroscopic approaches, and electrochemical (EC) methods. These methods are effective, but most of them still have some drawbacks such as consuming time, effort, and money. Added to that, sometimes they need complex procedures to obtain good sensitivity and suffer from low selectivity due to interference from other biological species such as uric acid (UA) and ascorbic acid (AA). Advanced materials can offer remarkable opportunities to overcome drawbacks in conventional DA sensors. This review aims to explain challenges related to DA detection using different techniques, and to summarize and highlight recent advancements in materials used and approaches applied for several sensor surface modification for the monitoring of DA. Also, it focuses on the analytical features of the EC and optical-based sensing techniques available.

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“…Non-conductive polymers are also used for neurotransmitter sensor development. The insulating properties of non-conductive polymers could minimize the electrochemical signal produced from interferences, therefore, the selectivity of the sensor was improved [58]. Table 2 lists the recently published works on polymer-based neurotransmitter sensors.…”

Section: Polymer-based Sensormentioning

confidence: 99%

“…The high surface area and promising ion-exchange characteristics of the nanowire-based POA have greatly enhanced the electrical signal transduction for dopamine. Wu et al introduced a selective poly-o-phenylenediamine (P-o-PD) sensor for dopamine detection [58]. Their work demonstrated the feasibility of o-PD as dopamine-imprinted MIP.…”

Section: Polymer-based Sensormentioning

confidence: 99%

Recent Advances in the Detection of Neurotransmitters

Song

2018

Chemosensors

148

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Neurotransmitters are chemicals that act as messengers in the synaptic transmission process. They are essential for human health and any imbalance in their activities can cause serious mental disorders such as Parkinson's disease, schizophrenia, and Alzheimer's disease. Hence, monitoring the concentrations of various neurotransmitters is of great importance in studying and diagnosing such mental illnesses. Recently, many researchers have explored the use of unique materials for developing biosensors for both in vivo and ex vivo neurotransmitter detection. A combination of nanomaterials, polymers, and biomolecules were incorporated to implement such sensor devices. For in vivo detection, electrochemical sensing has been commonly applied, with fast-scan cyclic voltammetry being the most promising technique to date, due to the advantages such as easy miniaturization, simple device architecture, and high sensitivity. However, the main challenges for in vivo electrochemical neurotransmitter sensors are limited target selectivity, large background signal and noise, and device fouling and degradation over time. Therefore, achieving simultaneous detection of multiple neurotransmitters in real time with long-term stability remains the focus of research. The purpose of this review paper is to summarize the recently developed sensing techniques with the focus on neurotransmitters as the target analyte, and to discuss the outlook of simultaneous detection of multiple neurotransmitter species. This paper is organized as follows: firstly, the common materials used for developing neurotransmitter sensors are discussed. Secondly, several sensor surface modification approaches to enhance sensing performance are reviewed. Finally, we discuss recent developments in the simultaneous detection capability of multiple neurotransmitters.

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Sensitive and selective determination of dopamine by electrochemical sensor based on molecularly imprinted electropolymerization of o-phenylenediamine

Cited by 39 publications

References 23 publications

Electrochemical Biosensing of Dopamine Neurotransmitter: A Review

Electrochemical Biosensing of Dopamine Neurotransmitter: A Review

Recent Advances in Electrochemical and Optical Sensing of Dopamine

Recent Advances in the Detection of Neurotransmitters

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