Sensitisation to aeroallergens among asthmatic and non-asthmatic adolescents living in a poor region in the Northeast of Brazil

Sarinho, Emanuel; Mariano, Jose Alberto; Sarinho, Sílvia Wanick; Medeiros, Décio; Rizzo, José Ângelo; Solé, Dírceu

doi:10.1016/j.aller.2009.03.009

Cited by 17 publications

(11 citation statements)

References 22 publications

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“…Exposure to molds is associated with allergic diseases, however, it prevalence vary widely probably because of environmental differences, and wide range of diagnostic tests used [ 2 ]. We assessed aeroallergen exposure through a questionnaire, not with objective measures, however, the results was similar to data obtained by Brazilian studies, with sensitization prevalence between 46.8% [ 35 ] and 54% [ 36 ] to at least one aeroallergen in asthmatic children evaluated by skin prick test or standard allergen extracts panel.…”

Section: Discussionsupporting

confidence: 65%

Asthma exacerbations in a subtropical area and the role of respiratory viruses: a cross-sectional study

et al. 2018

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BackgroundMultiple factors are involved in asthma exacerbations, including environmental exposure and viral infections. We aimed to assess the association between severe asthma exacerbations, acute respiratory viral infections and other potential risk factors.MethodsAsthmatic children aged 4–14 years were enrolled for a period of 12 months and divided into two groups: those with exacerbated asthma (group 1) and non-exacerbated asthma (group 2). Clinical data were obtained and nasopharyngeal samples were collected through nasopharyngeal aspirate or swab and analysed via indirect fluorescent immunoassays to detect influenza A and B viruses, parainfluenza 1–3, adenovirus and respiratory syncytial virus. Rhinovirus was detected via molecular assays. Potential risk factors for asthma exacerbation were identified in univariate and multivariate analyses.ResultsIn 153 children (group 1: 92; group 2: 61), median age 7 and 8 years, respectively, the rate of virus detection was 87.7%. There was no difference between groups regarding the frequency of virus detection (p = 0.68); however, group 1 showed a lower frequency (19.2%) of inhaled corticosteroid use (91.4%, p < 0.01) and evidence of inadequate disease control. In the multivariate analysis, the occurrence of three or more visits to the emergency room in the past 12 months (IRR = 1.40; p = 0.04) and nonadherence to inhaled corticosteroid (IRR = 4.87; p < 0.01) were the only factors associated with exacerbation.ConclusionOur results suggest an association between asthma exacerbations, poor disease control and nonadherence to asthma medication, suggesting that viruses may not be the only culprits for asthma exacerbations in this population.

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Section: Discussionsupporting

confidence: 65%

Asthma exacerbations in a subtropical area and the role of respiratory viruses: a cross-sectional study

et al. 2018

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“…Considering that asthma results from the complex interplay between genetic susceptibility and ubiquitous environmental factors, avoiding the latter completely may not only seem impossible but impractical and very limiting to the patient. It is more important, therefore, to resolve the HDM level that could result to either sensitization or tolerance since sensitization to HDMs among asthmatic adolescents has been demonstrated to be not significantly different from non-asthmatics [26]. …”

Section: Discussionmentioning

confidence: 99%

Association of house dust mite-specific IgE with asthma control, medications and household pets

Albano

Ramos

2011

Asia Pacific Allergy

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BackgroundEvidence is conflicting regarding the effectiveness of creating a low-allergen environment or reducing allergen exposure to control asthma exacerbations.ObjectiveThis study determined the association of house dust mite (HDM)-specific IgE levels with asthma symptom control, selected medications, family history of allergic disease, and exposure to second-hand smoke and household pets.MethodsSerum samples from 102 doctor-diagnosed allergic asthma patients and 100 non-atopic controls were subjected to enzyme-linked immunosorbent assay using the HDM species Dermatophagoides pteronyssinus (Dp), Dermatophagoides farinae (Df), and Blomia tropicalis (Bt) allergens. Point-biserial correlation coefficient, Pearson R correlation, and logistic regression analyses were used to determine association of HDM-specific IgE levels with the abovementioned variables.ResultsOf the 102 cases, 38.24%, 47.06%, and 33.33% were sensitized to Bt, Df, and Dp, respectively. Sensitized patients showed greater probability [Bt (OR = 1.21), Df (OR = 1.14), and Dp (OR = 1.35)] to manifest symptoms than those who were not. Obtained p-values [Bt (p = 0.73), Df (p = 0.83), and Dp (p = 0.59)], however, proved that HDM-specific IgE levels had no significant contribution in predicting or explaining occurrence of asthma symptoms. Bt- and Df-specific IgEs showed moderately weak but significant relationship with bambuterol HCl and expectorant, respectively. Patients currently on said medications registered higher HDM-specific IgE levels than those who were not. No significant correlation between IgE levels and family history of allergic disease or with exposure to second-hand smoke was seen. Dp-specific IgE levels of patients exposed to household pets were significantly lower compared to those without exposure.ConclusionThis study proves that sensitization to Bt, Df, and Dp allergens is not significantly associated with asthma symptoms and control. Although cases were shown to be sensitized to HDMs, their current medications were at least effective in controlling their asthma symptoms.

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“…On the other hand, Sarinho et al , studying asthmatic and non-asthmatic adolescents from the municipality of Caruaru, state of Pernambuco, northeastern Brazil, observed a 54.0% prevalence of sensitization for asthmatics, with prevalence of sensitization to cockroach allergens ( 49 ) . Previous findings point to the need for local studies, with the aim of identifying the most relevant allergens and guiding more targeted therapeutic actions.…”

Section: Isaac Phase IIImentioning

confidence: 99%

“…Por outro lado, Sarinho et al , ao estudarem adolescentes asmáticos e não asmáticos da cidade de Caruaru, nordeste brasileiro, observaram prevalência de sensibilização de 54,0%para os asmáticos, com predomínio de sensibilização aos alérgenos da barata ( 49 ) . Os achados anteriores apontam para a necessidade de estudos locais, com o intuito de se identificarem os alérgenos de maior relevância e orientar condutas terapêuticas mais bem direcionadas.…”

Section: Isaac Fase IIIunclassified

Asthma in children and adolescents in Brazil: contribution of the International Study of Asthma and Allergies in Childhood (ISAAC)

Solé

Camelo-Nunes

Wandalsen

et al. 2014

Rev. paul. pediatr.

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Objective: To assess asthma among Brazilian pediatric population applying the International Study of Asthma and Allergies in Childhood (ISAAC), an internationally standardized and validated protocol. Data sources: ISAAC was conceived to maximize the value of epidemiologic studies on asthma and allergic diseases, establishing a standardized method (self-applicable written questionnaire and/or video questionnaire) capable to facilitate the international collaboration. Designed to be carried out in three successive and dependent phases, the ISAAC gathered a casuistic hitherto unimaginable in the world and in Brazil. This review included data gathered from ISAAC official Brazilian centers and others who used this method. Data synthesis: At the end of the first phase, it has been documented that the prevalence of asthma among Brazilian schoolchildren was the eighth among all centers participating all over the world. Few centers participated in the second phase and investigated possible etiological factors, especially those suggested by the first phase, and brought forth many conjectures. The third phase, repeated seven years later, assessed the evolutionary trend of asthma and allergic diseases prevalence in centers that participated simultaneously in phases I and III and in other centers not involved in phase I. Conclusions: In Brazil, the ISAAC study showed that asthma is a disease of high prevalence and impact in children and adolescents and should be seen as a Public Health problem. Important regional variations, not well understood yet, and several risk factors were found, which makes us wonder: is there only one or many asthmas in Brazil?

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Sensitisation to aeroallergens among asthmatic and non-asthmatic adolescents living in a poor region in the Northeast of Brazil

Cited by 17 publications

References 22 publications

Asthma exacerbations in a subtropical area and the role of respiratory viruses: a cross-sectional study

Asthma exacerbations in a subtropical area and the role of respiratory viruses: a cross-sectional study

Association of house dust mite-specific IgE with asthma control, medications and household pets

Asthma in children and adolescents in Brazil: contribution of the International Study of Asthma and Allergies in Childhood (ISAAC)

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