Sensing Properties of NH2-MIL-101 Series for Specific Amino Acids via Turn-On Fluorescence

Abstract

Metal–organic frameworks (MOFs) have been demonstrated to be desired candidates for sensing definite species owing to their tunable composition, framework structure and functionality. In this work, the NH2-MIL-101 series was utilized for sensing specific amino acids. The results show that cysteine (Cys) can significantly enhance the fluorescence emission of NH2-MIL-101-Fe suspended in water, while NH2-MIL-101-Al exhibits the ability to sense lysine (Lys), arginine (Arg) and histidine (His) in aqueous media via turn-on fluorescence emission. Titration experiments ensure that NH2-MIL-101-Fe and NH2-MIL-101-Al can selectively and quantitatively detect these amino acids. The sensing mechanism was examined and discussed. The results of this study show that the metal centers in MOFs are crucial for sensing specific amino acids.

Pillar-Layered Metal-Organic Frameworks for Sensing Specific Amino Acid and Photocatalyzing Rhodamine B Degradation

“…Besides, the unique porous structure may be helpful for adsorbing target analytes which may be selectively interacting with the framework by the porous skeleton [ 12 , 13 ]. In our previous work, it was found that the amino-functionalized MOF, namely NH 2 -MIL-101, can be utilized for sensing specific AA in aqueous media via turn-on fluorescence [ 14 ]. In addition to the detection, MOFs have also been widely employed in photocatalysis, like water splitting, CO 2 reduction, organic reactions and so on [ 15 , 16 , 17 , 18 , 19 , 20 ].…”

Metal–organic framework (MOF)-based fluorescence “turn-on” sensors

“…Amino acids are the basic building blocks for proteins in the living body. 111,112 In the food industry, arginine tends to release urea by fermentation. However, if the arginine content is high, then a high amount of urea will be released, which reacts with ethanol to produce urethane, posing carcinogenic threat to human health.…”

Progressive Trends on the Biomedical Applications of Metal Organic Frameworks

“…Consequently, coordination with the amino acid-derived MOFs possesses chirality and is utilized for specific and selective sensing and separation. Various BioMOFs (like MOF-11, NH 2 -MIL-101(Al), NH 2 -MIL-53(Al), and NH 2 -MIL-101(Cr) have been synthesized and reported for biological applications [ 156 , 157 , 158 , 159 ].…”