Sensing of zinc ions and sulfide using a highly practical and water-soluble fluorescent sensor: applications in test kits and zebrafish

Yun, Dongju; Chae, Ju Byeong; So, Haeri; Lee, Hyojin; Kim, Ki-Tae; Kim, Cheal

doi:10.1039/c9nj05057d

Cited by 34 publications

(11 citation statements)

References 69 publications

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“…The Kim group recently reported a Zn 2+ -based IDA ( P12.16 in Figure ) for S 2– detection which was tolerant to other anions, including CN – and I – , in 10 mM Bis-Tris buffer, pH 7.0, and even allowed for the Zn 2+ detection in zebrafish . The detection limit of P12.16 for Zn 2+ and for S 2– were 0.3 and 2.4 μM, respectively, and therefore lower than the requirements specified by the WHO guidelines (76.0 and 14.7 μM) for drinking water.…”

Section: Inorganic Anionsmentioning

confidence: 97%

Molecular Probes, Chemosensors, and Nanosensors for Optical Detection of Biorelevant Molecules and Ions in Aqueous Media and Biofluids

et al. 2022

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Synthetic molecular probes, chemosensors, and nanosensors used in combination with innovative assay protocols hold great potential for the development of robust, low-cost, and fast-responding sensors that are applicable in biofluids (urine, blood, and saliva). Particularly, the development of sensors for metabolites, neurotransmitters, drugs, and inorganic ions is highly desirable due to a lack of suitable biosensors. In addition, the monitoring and analysis of metabolic and signaling networks in cells and organisms by optical probes and chemosensors is becoming increasingly important in molecular biology and medicine. Thus, new perspectives for personalized diagnostics, theranostics, and biochemical/ medical research will be unlocked when standing limitations of artificial binders and receptors are overcome. In this review, we survey synthetic sensing systems that have promising (future) application potential for the detection of small molecules, cations, and anions in aqueous media and biofluids. Special attention was given to sensing systems that provide a readily measurable optical signal through dynamic covalent chemistry, supramolecular host− guest interactions, or nanoparticles featuring plasmonic effects. This review shall also enable the reader to evaluate the current performance of molecular probes, chemosensors, and nanosensors in terms of sensitivity and selectivity with respect to practical requirement, and thereby inspiring new ideas for the development of further advanced systems.

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Section: Inorganic Anionsmentioning

confidence: 97%

Molecular Probes, Chemosensors, and Nanosensors for Optical Detection of Biorelevant Molecules and Ions in Aqueous Media and Biofluids

et al. 2022

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“…29,30 Especially, the sensors for relay sensing of metal ions and biothiols have attracted much attention. [31][32][33] Unlike the detection methods for biothiols based on covalent interaction accompanying long response time, relay detection methods have been usually studied by utilizing a high affinity between metal ions and thiols with fast response time. [34][35][36][37][38][39] Hence, we focused on developing a sequential functioning sensor for detecting metal ion like Cu 2+ and biological thiols (GSH, Cys, and Hcy) by using a chromophore.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, many optical sensors for detecting various analytes have been addressed based on chromophores or fluorophores like quinoline, 21,22 BODIPY (Boron dipyrromethene difluoride), 23,24 coumarin, 25,26 NBD (Nitrobenzoxadiazole), 27,28 and rhodamine 29,30 . Especially, the sensors for relay sensing of metal ions and biothiols have attracted much attention 31–33 . Unlike the detection methods for biothiols based on covalent interaction accompanying long response time, relay detection methods have been usually studied by utilizing a high affinity between metal ions and thiols with fast response time 34–39 .…”

Section: Introductionmentioning

confidence: 99%

Construction of a Quinoline‐based Sequential Functioning Chromogenic Sensor for Copper(II) Ion and Biothiols: Its Application to Test Strips

Park

Kim

2021

Bulletin Korean Chem Soc

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A new compound BQ ((1E,1'E)-N,N'-((1,3-phenylenebis(oxy))bis(3,1-phenylene))bis(1-(quinolin-2-yl) methanimine)) containing quinoline moiety has been developed as a sequential functioning chromogenic sensor for copper(II) ion and biological thiols (GSH, Cys, and Hcy). BQ had a clear chromogenic response toward only copper ion with a red-shifted absorption. Detection limit for copper(II) ion was calculated to be 1.20 μM. Its application was successfully conducted in test strips. The resultant BQ-Cu 2+ complex could detect the biological thiols, showing the color change and blue-shifted absorption via the demetallation of copper(II) ion. The possible binding mechanisms of BQ to copper(II) ion and of BQ-Cu 2+ to biological thiols were understood by UV-vis titrations, Job plot, ESI-MS, and 1 H NMR titrations.

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“…Zinc is the second most abundant transition metal ion in the human body that plays important metabolic roles, including those in neurological signaling and enzymatic reactions, cell growth, protein and DNA synthesis, and immune function [5,6]. Several artificial receptors for Zn ion have been developed based on quinoline [7][8][9][10][11][12][13], coumarin [14][15][16][17][18][19][20], benzoxazole [21][22][23][24], BODIPY [25,26], BINOL [27][28][29], fluorescein [30][31][32], and rhodamine [33][34][35][36][37] fluorophores.…”

Section: Introductionmentioning

confidence: 99%

Solid-State Emissive Metallo-Supramolecular Assemblies of Quinoline-Based Acyl Hydrazone

Cho

Kim

et al. 2020

Sensors

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Development of fluorescence-based sensory materials for metal elements is currently in the mainstream of research due to the simplicity and usability of fluorescence as a method of detection. Herein, we report a novel “bis”-quinoline-based acyl hydrazone—named bQH that could be synthesized by a facile, low-cost method through simple condensation of hydrazide with an aldehyde. This acyl hydrazone showed emissive properties through Zn selective binding, especially in its solid-state, as shown by experiments such as UV–Vis, photoluminescence (PL), nuclear magnetic resonance (NMR), and inductively-coupled plasma-optical emission spectroscopies (ICP-OES), and energy-dispersive X-ray spectroscopy (EDS) mapping. The binding modes in which bQH coordinates to Zn2+ was proved to consist of two modes, 1:1 and 1:2 (bQH:Zn2+), where the binding mode was controlled by the Zn2+ ion content. Under the 1:1 binding mode, bQH-Zn2+ complexes formed a polymeric array through the metallo-supramolecular assembly. The resulting bQH-Zn2+ complex maintained its fluorescence in solid-state and exhibited excellent fluorescence intensity as compared to the previously reported quinoline-based acyl hydrazone derivative (mQH).

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Sensing of zinc ions and sulfide using a highly practical and water-soluble fluorescent sensor: applications in test kits and zebrafish

Abstract: A practical fluorescent sensor was synthesized for recognition of Zn2+ and S2− and applied in various applications such as in live zebrafish.

Cited by 34 publications

References 69 publications

Molecular Probes, Chemosensors, and Nanosensors for Optical Detection of Biorelevant Molecules and Ions in Aqueous Media and Biofluids

Molecular Probes, Chemosensors, and Nanosensors for Optical Detection of Biorelevant Molecules and Ions in Aqueous Media and Biofluids

Construction of a Quinoline‐based Sequential Functioning Chromogenic Sensor for Copper(II) Ion and Biothiols: Its Application to Test Strips

Solid-State Emissive Metallo-Supramolecular Assemblies of Quinoline-Based Acyl Hydrazone

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