Sensing of Phosphate and ATP by Lanthanide Complexes in Aqueous Medium and Its Application on Living Cells

Abstract

The design of coordination complexes as synthetic receptors for selective sensing of inorganic anions and nucleoside phosphates in aqueous medium under physiological conditions are important for biomedical research and drug delivery. In this work, two phenanthroline-based luminescent lanthanide complexes; EuLCl 3 (1) and TbLCl 3 (2), were explored for sensing anions such as HPO 4 2À , SO 4 2À , CH 3 COO À , I À , Br À , Cl À , F À , NO 3 À and HSO 4 À with HPO 4 2À exhibiting the strongest emission. Nucleoside phosphates such as ATP, ADP and AMP could be also detected. Both complexes 1 and 2 are highly selective sensing ATP at physiological pH. The detection limit and their corresponding Stern-Volmer quenching constant were calculated for ATP as in the range of 0.2 μM-1 mM and 2.0 × 10 6 M À 1. Complex 1 was applied as a staining agent to study alga cells (Microspora unialgal filamentous cell). The result shows that the ligand L causes a severe cytotoxic effect and induces the cell damage.

Luminescent Complexes of Europium (III) with 2-(Phenylethynyl)-1,10-phenanthroline: The Role of the Counterions

“…Since the antenna effect is extremely interesting from fundamental point of view, many theoretical and spectroscopic studies discussed the photophysical process of absorption of light, the excited state energy transfer from the ligand to the europium ion and the luminescent properties of these compounds [ 30 , 31 , 32 , 33 , 34 ]. Application-oriented investigations on phenanthroline-based complexes also demonstrated their importance for the advance technologies [ 35 , 36 , 37 , 38 , 39 , 40 ].…”

An overview on the development of different optical sensing platforms for adenosine triphosphate (ATP) recognition

“…Furthermore, complex 85 was used as a staining agent in live green algal cells. 126 Nadella et al reported a series of phenanthroline-based hexadentate ligands with two chiral imine moieties and their corresponding lanthanide complexes with various lanthanide ions such as La( iii ), Eu( iii ), Tb( iii ), Lu( iii ), and Y( iii ) metal ions with a coordination number nine. The crystal structures of these complexes [ML 1 Cl 3 ] (M = La( iii ), Eu( iii ), Tb( iii ), Lu( iii ), or Y( iii )) were also reported.…”

Carbon‐ZnO Composite Synthesized from ZIF‐8 Depositing Vegetable Biomass for Efficient Removal of Phosphate from Aqueous Solution

“…There is a pressing need to remove phosphate from aqueous solution, otherwise it can raise the possibility of aquatic ecosystem eutrophication. [2][3] In recent decades, chemical, physical, biological, and other techniques have been conducted to reduce phosphate from wastewater. [4][5] By comparison, adsorption is relatively economical and effective due to its simple remove process and low energy equipment.…”