Sensing of Antibiotic–Bacteria Interactions

Baranova, Anna A.; Tyurin, Anton P.; Korshun, Vladimir A.; Alferova, Vera A.

doi:10.3390/antibiotics12081340

Cited by 2 publications

(2 citation statements)

References 159 publications

(215 reference statements)

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“…Over the past 12 years, advancements in the application of BCP and similar methods in antibiotic research have received only brief mention in review articles covering other topics [6,26,27]. That is why we consider it necessary to conduct a more comprehensive and critical examination of the accumulated data.…”

Section: Fig 2 Main Steps Of Bacterial Cytological Profilingmentioning

confidence: 99%

“…The main problem with this approach is precisely the lack of information about the mechanism underlying the observed phenotypic changes. To solve this problem, various approaches have been developed to elucidate the mechanism of action, both newly developed [3,[6][7][8] and conventional, or "classical" ones. The "gold standard" for establishing the mechanism of action of an antibiotic is a macromolecular synthesis assay utilizing radioactively labeled precursors [9,10] (Fig.…”

Section: Introductionmentioning

confidence: 99%

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Imaging-based profiling for elucidation of antibacterial mechanisms of action

Baranova,

Alferova,

Korshun

et al. 2024

Preprint

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In this review, we aim to summarize experimental data and approaches to identifying cellular targets or mechanisms of action of antibacterials based on imaging techniques. Imaging-based profiling methods such as bacterial cytological profiling, dynamic bacterial morphology imaging and others have become a useful research tool for mechanistic studies of new antibiotics as well as combinations with conventional ones and other therapeutic options. The main methodological, experimental details and obtained results are summarized and discussed. The review covers the literature up to Feb 2024.

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Section: Fig 2 Main Steps Of Bacterial Cytological Profilingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Imaging-based profiling for elucidation of antibacterial mechanisms of action

Baranova,

Alferova,

Korshun

et al. 2024

Preprint

View full text Add to dashboard Cite

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Antibiotic resistance and a dire need for novel and innovative therapies: The impending crisis

Bhaskar

2023

Syncytia

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Antibiotic resistance poses an escalating global crisis as pathogens like the ESKAPE organisms –Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species—are evolving to evade our antibacterial arsenal. We desperately need innovative strategies to fill the pipeline with effective treatments. BioSAXS, which maps antibiotic targets using X-ray scattering and biophysics, and artificial intelligence, which expedites drug creation and screening, are two promising approaches. In addition to conventional antibiotics, scientists are investigating immunotherapies, phage treatment, antimicrobial peptides, and synergistic combinations. Major challenges still exist, though, in turning these insights into licensed medical interventions. Enhanced public-private partnerships, improved data sharing, and incentives like milestone prizes could help spur the development of new antimicrobials. Regulators should consider pathways to accelerate approval for therapies that address urgent needs against resistant infections. The COVID-19 pandemic spotlighted concerning gaps in infectious disease preparedness that must be addressed. With global coordination and increased funding, we can reignite antimicrobial discovery and development to combat superbugs before routine injuries and illnesses become untreatable again. Overcoming the scientific and economic challenges will require commitment from all stakeholders. We urgently need imagination and resolve to build a robust pipeline of novel therapies to meet the threat of modern “superbugs” before the antibacterial era comes to an end.

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Sensing of Antibiotic–Bacteria Interactions

Cited by 2 publications

References 159 publications

Imaging-based profiling for elucidation of antibacterial mechanisms of action

Imaging-based profiling for elucidation of antibacterial mechanisms of action

Antibiotic resistance and a dire need for novel and innovative therapies: The impending crisis

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