Imaging-based profiling for elucidation of antibacterial mechanisms of action
Anna A. Baranova,
Vera A. Alferova,
Vladimir A. Korshun
et al.
Abstract:In this review, we aim to summarize experimental data and approaches to identifying cellular targets or mechanisms of action of antibacterials based on imaging techniques. Imaging-based profiling methods such as bacterial cytological profiling, dynamic bacterial morphology imaging and others have become a useful research tool for mechanistic studies of new antibiotics as well as combinations with conventional ones and other therapeutic options. The main methodological, experimental details and obtained results… Show more
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