Sense of Smell in Long-Standing Nasal Polyposis

Vento, Seija; Simola, Markku; Ertama, Liisa; Malmberg, C. H. O.

doi:10.2500/105065801779954229

Cited by 37 publications

(26 citation statements)

References 10 publications

(2 reference statements)

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“…In our series we achieved 77% improvement, comparable to other reports [11,12,14]. Considering the 68.5% prevalence of nasal polyposis with worse prognosis, this is an acceptable level of improvement.…”

Section: Discussionsupporting

confidence: 78%

“…Perhaps this difference can be explained by dissimilarity of patients' characteristics or fallow up periods. [9,12].…”

Section: Discussionmentioning

confidence: 99%

“…Some reports claimed that only medical therapy using corticosteroids has effect on improving olfactory sensation [7], but other reports shows the effect of sinus surgery on it [8]. Moreover, the outcome of postoperative smell depends upon the type of surgery and condition of the patient [8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

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Effectiveness of FESS in Smell Improvement of Sinusitis Patients

Saedi

Sadeghi

Yazdani

et al. 2012

Indian J Otolaryngol Head Neck Surg

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The aim of this research was to verify the effect of functional endoscopic sinus surgery (FESS) on olfactory dysfunction in patients who suffer from chronic rhinosinusitis. We enrolled prospective consecutive patients at a tertiary institution who were undergoing FESS; for these patients prolonged medical therapy for chronic rhinosinusitis had failed. Patients were asked to grade their olfactory dysfunction from 1 to 5 with 1 representing lack of any smell function and 5 representing a completely normal sense of smell. Moreover, the pre-and postoperative smell identification test of the University of Pennsylvania was performed for all participating patients. In addition, data including computed tomography scores, nasal endoscopy, and the presence or absence of asthma as well as smoking habits were recorded and analyzed. Patients were followed at least 1 year after surgery. Data were collected on 89 patients who had undergone sinus surgery. Postoperative olfactory function was 77% improved for all subjects as a group. Higher involvement of sinus in computed tomography correlated with poorer results in olfactory UPSIT40 score. Patients' olfaction was significantly related to polyp pathology, duration of disease, age, smoking habits and history of asthma. A variety of patients' characteristics have impact on olfactory outcome of sinusitis patients after FESS.

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Section: Discussionsupporting

confidence: 78%

“…Perhaps this difference can be explained by dissimilarity of patients' characteristics or fallow up periods. [9,12].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effectiveness of FESS in Smell Improvement of Sinusitis Patients

Saedi

Sadeghi

Yazdani

et al. 2012

Indian J Otolaryngol Head Neck Surg

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“…The osteomeatal complex is scored with 0 (not obstructed) or 2 (obstructed). Although all paranasal sinuses are graded and contribute to the staging score, we used it in this study as an indicator of the inflammatory process in the nasal cavities, which is a significant factor for the olfactory dysfunction in nasal pathology [2,3,17] .…”

Section: The Lund-mackay System Scorementioning

confidence: 99%

Olfactory Dysfunction in Nasal Polyposis: Correlation with Computed Tomography Findings

Konstantinidis¹,

Triaridis²,

Printza³

et al. 2007

ORL

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Aims: This study evaluates if a computed tomography (CT) scan is useful to assess the olfactory loss in sinonasal disease, and if a preoperative CT scan has a predictive value for the long-term outcome regarding olfaction. Methods: Thirty-one patients with nasal polyposis were included. Olfactory function was assessed with the ‘Sniffin’ Sticks’ test and subjective perception recorded with a visual analogue scale. CT scans were assessed with the Lund-Mackay system and the Damm nasal segmentation. Patients were retested after endoscopic sinus surgery in a follow-up appointment at least 1 year later. Results: Disease in the upper meatus and the posterior portion of the middle meatus strongly affects olfactory function. Lund-Mackay scores were significantly correlated with preoperative olfactory test results. Preoperative subjective ratings had a significant correlation only with present disease in the anterior upper meatus. Postoperative results were significantly decreased. Their relative percentage change was correlated only with the preoperative presence of disease in the anterior upper meatus. No correlation was found between the Lund-Mackay score and the postoperative olfactory results. Conclusions: Olfactory dysfunction in nasal polyposis is strongly related to specific obstructed nasal areas. A CT scan has no predictive value for the long-term surgical outcome regarding olfaction.

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“…In addition, cytokines and mediators, particularly those released by eosinophils, may be toxic to olfactory receptor neurons (Apter et al, 1992;Nakashima et al, 1985), and the degree of inflammation changes in the neuropithelium is related to the severity of olfactory dysfunction (Kern, 2000) Patients with nasal polyps show a higher incidence of olfactory disturbances and a higher incidence of anosmia than patients with CRS without polyps. This more severe symptomatology may be explained by the conductive olfactory loss induced by polyps but also by degenerative changes associated with recurrent infections, scaring, chronic nasal medication, exotoxins and enhanced secretion of cytokines from Staphylococcus Aureus infection and neurotoxic cytokines released by a huge eosinophilic population (Bernstein et al, 2011;Holcomb et al, 1996;Joshi et al, 1987;Litvack et al, 2008;Vento et al, 2001;Wang et al, 2010).…”

Section: Pathophysiologymentioning

confidence: 99%