Senile Lens and Senile Macular Changes in a Population-Based Sample

Sperduto, Robert D.; Seigel, Daniel

doi:10.1016/s0002-9394(14)75081-0

Cited by 104 publications

(27 citation statements)

References 4 publications

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“…Its pathology is the opacification of the lens [2]. The development of lens opacities is concomitant with aging in virtually every human population study [3][4][5]. The biochemical processes responsible for the development of these opacities are poorly understood [3].…”

Section: Introductionmentioning

confidence: 99%

Nickel, Chromium, Manganese, Iron and Aluminum Levels in Human Cataractous and Normal Lenses

Çekıç

Bardak²,

Totan³

et al. 1999

Ophthalmic Res

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Atomic absorption spectrophotometry was used to detect lenticular nickel, chromium, manganese, iron and aluminum levels in 37 senile cataractous and 9 normal human lenses. The nuclear parts of the lenses were used for the study in both groups. It was found that the concentrations of nickel and iron were significantly higher, and those of chromium, manganese and aluminum were significantly lower in human cataractous lenses than those in normal human lenses. None of the elements showed a significant difference according to sex in both groups. As remarkable differences in chromium, manganese, iron, aluminum and nickel levels exist in cataractous lenses, all the five elements may play some roles in cataractogenesis.

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Section: Introductionmentioning

confidence: 99%

Nickel, Chromium, Manganese, Iron and Aluminum Levels in Human Cataractous and Normal Lenses

Çekıç

Bardak²,

Totan³

et al. 1999

Ophthalmic Res

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“…Several studies have reported rates computed from data derived from various samplings of the Framingham heart study cohort. [1][2][3][4] Variability in the prevalence rates derived from this cohort can be attributed to differing definitions of the disease, restricting the sample age range (52 to 85 years of age), and requiring subjects to present with a Snellen acuity of 6/9 or less before undergoing a fundus exam-ination.…”

mentioning

confidence: 99%

Prevalence of age related macular degeneration in persons aged 50 years and over resident in Australia.

Mitchell

1993

Journal of Epidemiology & Community Health

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Study objective-The aim was to determine, employing non-invasive procedures, the prevalence of age related macular degeneration in persons 50 years of age and over.Design-A clinical investigation and a retrospective examination of ophthalmological records were employed in this study.Setting-The study was conducted over the period 1988 to 1990 Other studies have computed rates for age related macular degeneration from samples which did not have an upper age limit.5 6 However, in both of these studies the samples were specialised, self selecting, and either had a pre-existing medical condition or were attending an ophthalmological clinic.Irrespective of the source of the sample and the associated errors of measurement, definition of disease, and restricted age range, all research on age related macular degeneration shows an increase in prevalence with age. The prevalence findings across age groups for the studies cited above are summarised in table I.Each of the above studies presents with one or more limitations which prevent generalisations of their findings to the elderly population 50 years of age and over. These limitations can be categorised into three generic areas; the manner in which the disease is defined, the inclusion of a certain Snellen visual acuity criterion as a sign of the disease, and finally the nature of the sample used in the specific study. These three general limitations lead to some question as to the accuracy of the prevalence rates presented for age related macular degeneration. The aim of the present study was to determine, employing non-invasive procedures, the prevalence of this disorder in persons 50 years of age and over. Methods

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“…The known association of ARM and cataract needs to be kept in mind (Sperduto & Seigel 1980;Liu et al 1989;Klein et al 1994). It has been suggested that AMD and senile nuclear cataracts have the same pathogenesis (Klein et al 1994), which may indicate similar risk factors and mechanisms of prevention.…”

Section: Discussionmentioning

confidence: 99%

Six‐year supplementation with alpha‐tocopherol and beta‐carotene and age‐related maculopathy

Teikari¹,

Laatikainen

Virtamo

et al. 1998

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: Animal research and observational studies in man suggest a protective effect of antioxidant vitamins in the development of age-related maculopathy (ARM). Methods: The ATBC study, a population-based, controlled clinical trial of alpha-tocopherol and beta carotene to prevent lung cancer, took place in Finland between 1984 and 1993. Over 29,000 smoking males aged 50 to 69 years were randomly assigned to alpha-tocopherol (AT; 50 mg/day), beta-carotene (BC; 20 mg/day), both of these, or placebo. We performed an end-of-trial ophthalmological examination on a random sample of 941 participants aged 65 years or more from two of the fourteen study areas, to discover if the five to eight-year intervention with alpha-tocopherol and/or beta-carotene had been associated with a difference in ARM prevalence. Age-related maculopathy was assessed using colour photographs of the macula. Results: Altogether, 269 cases of ARM were found; there were more cases in the AT group (32%; 75/237), BC group (29%; 68/234), and combined antioxidant group (28%; 73/257) than in the placebo group (25%; 53/213). However, neither substance was significantly associated with the risk of ARM in a logistic regression analysis controlling for possible risk factors. Conclusions: No beneficial effect of long-term supplementation with alpha-tocopherol or beta-carotene on the occurrence of ARM was detected among smoking males.

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Senile Lens and Senile Macular Changes in a Population-Based Sample

Cited by 104 publications

References 4 publications

Nickel, Chromium, Manganese, Iron and Aluminum Levels in Human Cataractous and Normal Lenses

Nickel, Chromium, Manganese, Iron and Aluminum Levels in Human Cataractous and Normal Lenses

Prevalence of age related macular degeneration in persons aged 50 years and over resident in Australia.

Six‐year supplementation with alpha‐tocopherol and beta‐carotene and age‐related maculopathy

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