Semisynthetic penicillins. A structure-activity study of a new series of acyl amino acid-pyridone and pyrimidone amoxicillin analogs.

Abstract

The synthesis and biological activities of a series of 12 new semisynthetic penicillins is described. These compounds consisted of acylated amino acid analogs of 6-substituted-l,2-dihydro-2-oxonicotinic acid and 2-substituted-3,4-dihydro-4-oxo-5-pyrimidinecarboxylic acid attached to amoxicillin. The effect of the amino acid substitutnt, chirality of amino acid and acyl function on biological properties is discussed.