Thiazoles are notable five-membered heterocyclic rings and their moieties can be found in several
biologically active compounds of natural origin, as well as synthetic molecules that possess a wide
range of pharmacological activities. Inflammation is the common cause that is associated with different
disorders and diseases such as psoriasis, arthritis, infections, asthma, cancer, etc. In this article, the
synthesis pattern of these novel molecules are discussed and their anti-inflammatory activities against
cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) were reviewed and
documented. The potent 26 thiazole analogs were validated with molecular docking against main protease
(6LU7) and spike binding domain ACE2 receptor (6M0J) to defeat from the COVID-19 infections.
Among this, THI-9a showed excellent binding energy and affinity against deadly SAR CoV-2. The
reviewed and theoretical study information strongly suggested that thiazole derivatives can be used for
the development of futuristic target drugs against death-causing diseases like SAR-CoV-2.
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