Semisynthetic hybrids of boswellic acids: a novel class of potential anti-inflammatory and anti-arthritic agents

Chaturvedi, Devdutt; Dwivedi, Parmesh Kumar; Chaturvedi, Amit K.; Mishra, Niraj; Siddiqui, Hefazat Hussain; Mishra, Virendra

doi:10.1007/s00044-015-1331-y

Cited by 11 publications

(6 citation statements)

References 35 publications

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“…Chaturvedi et al [ 99 ] reported the synthesis of some new fused compounds containing boswellic acid (BA)/11‐keto‐β‐boswellic acid (KBA) and aspirin, naproxen, ibuprofen, and cinnamic acid (Scheme 59). These fused compounds were screened for their anti‐inflammatory and antiarthritic activities.…”

Section: Development Of Antiarthritic Agents So Farmentioning

confidence: 99%

Therapeutic management of arthritis: A review on structural and target‐based approaches

Mahore

Kamboj

Kaleem

et al. 2022

Archiv der Pharmazie

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Inflammation is the natural defense mechanism against any external stimuli in the human body and it saves us from foreign entities that may alter our bodies' normal functioning. Any anomaly in this natural defense system leads to the development of different pathological conditions associated with chronic inflammation like rheumatoid arthritis, osteoarthritis, atopy, asthma, allergic rhino-conjunctivitis, coronary artery disease, cardiac arrhythmias, obesity, insulin resistance and type-2 diabetes, depression, and aging. These disorders impair the quality of life of affected people in different ways. Among these, rheumatoid arthritis and osteoarthritis are the most common chronic inflammation-associated disorders. Different therapeutic strategies are already available for the treatment of rheumatoid arthritis and osteoarthritis, but all with pros and cons. Here, we discuss the emergence of several antiarthritic analogs developed by different researchers which could provide the basis for the evolution of newer therapeutic strategies with better activity and safety profiles.

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Section: Development Of Antiarthritic Agents So Farmentioning

confidence: 99%

Therapeutic management of arthritis: A review on structural and target‐based approaches

Mahore

Kamboj

Kaleem

et al. 2022

Archiv der Pharmazie

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“…Some derivatives of BA and KBA with wellknown anti-inflammatory drugs (i.e., aspirin, naproxen, ibuprofen and cinnamic acid) have been synthesized and evaluated for their anti-inflammatory and anti-arthritic activities. Among synthesized compounds, two compounds bearing naproxen and BA/KBA unit have displayed potent anti-inflammatory and anti-arthritic activities [38].…”

Section: Boswellic Acid (Ba)mentioning

confidence: 99%

Current Developments on Anti-Inflammatory Natural Medicines

Das¹,

Mandal²

2018

Asian J Pharm Clin Res

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New anti-inflammatory substances are still vitally necessary due to intolerable side effects of the marketed anti-inflammatory drugs; however, the search for the novel entity against inflammation is challenging because of the complexity of the inflammatory process and its role in host defense to infections. Nature is the source of remedies for the mankind. Among the different biological activities of natural products that have been published till date, anti-inflammation is one of the most reported effects. In this review, we have discussed the current (2009–2018) information of some single natural products (quercetin, parthenolide, resveratrol, curcumin, cucurbitacin, capsicin, 1,8-cineole, bromelain, boswellic acid, lyprinol, and coumarin), plant products (garlic, ginger, papaya, blueberry, aloe, broccoli, olive, and rosemary), and non-plant products (marine sponges, mushrooms, and honey) having anti-inflammatory effects. Current information is mainly based on the molecular mechanisms of the above-mentioned products.

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“…Based on these positive effects, clinical trials have been conducted using BA to treat Crohn’s disease, chronic colitis, ulcerative colitis, and brain tumors [197]. BA consists of four components, β-boswellic acid (β-BA), acetyl-β-boswellic acid (ABA), 11-keto-boswellic acid (KBA), and 11-keto-β-acetyl-11-keto-β-boswellic acid (AKBA) [198]. KBA and AKBA are among the main compounds responsible for the pharmacologic effects of BA.…”

Section: Natural Compounds Alter Epigenetic Modifications Via Epigmentioning

confidence: 99%

Natural compound-derived epigenetic regulators targeting epigenetic readers, writers and erasers

Yang¹,

Kim²,

Li³

et al. 2015

CTMC

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Post-translational modifications can affect gene expression in a long-term manner without changes in the primary nucleotide sequence of the DNA. These epigenetic alterations involve dynamic processes that occur in histones, chromatin-associated proteins and DNA. In response to environmental stimuli, abnormal epigenetic alterations cause disorders in the cell cycle, apoptosis and other cellular processes and thus contribute to the incidence of diverse diseases, including cancers. In this review, we will summarize recent studies focusing on certain epigenetic readers, writers, and erasers associated with cancer development and how newly discovered natural compounds and their derivatives could interact with these targets. These advances provide insights into epigenetic alterations in cancers and the potential utility of these alterations as therapeutic targets for the future development of chemopreventive and chemotherapeutic drugs.

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Semisynthetic hybrids of boswellic acids: a novel class of potential anti-inflammatory and anti-arthritic agents

Cited by 11 publications

References 35 publications

Therapeutic management of arthritis: A review on structural and target‐based approaches

Therapeutic management of arthritis: A review on structural and target‐based approaches

Current Developments on Anti-Inflammatory Natural Medicines

Natural compound-derived epigenetic regulators targeting epigenetic readers, writers and erasers

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