Semisynthetic Derivatives of Eugenol and their Biological Properties: A Fleeting Look at the Promising Molecules

Anjum, Noor Fathima; Purohit, Madhusudan; Kumar, H. Yogish; Ramya, K.; Javid, Saleem; Salahuddin,; Kumar, B. R. Prashantha

doi:10.1080/22311866.2020.1837674

Cited by 3 publications

(4 citation statements)

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“…Thanks to its highly versatile structure, several eugenol derivatives have been synthesized for different biological purposes in the past ten years [ 181 , 182 ]. Moreover, eugenol can be used as a scaffold to synthesize biologically active natural products [ 183 , 184 ].…”

Section: Monophenolsmentioning

confidence: 99%

Tailored Functionalization of Natural Phenols to Improve Biological Activity

et al. 2021

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Phenols are widespread in nature, being the major components of several plants and essential oils. Natural phenols’ anti-microbial, anti-bacterial, anti-oxidant, pharmacological and nutritional properties are, nowadays, well established. Hence, given their peculiar biological role, numerous studies are currently ongoing to overcome their limitations, as well as to enhance their activity. In this review, the functionalization of selected natural phenols is critically examined, mainly highlighting their improved bioactivity after the proper chemical transformations. In particular, functionalization of the most abundant naturally occurring monophenols, diphenols, lipidic phenols, phenolic acids, polyphenols and curcumin derivatives is explored.

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Section: Monophenolsmentioning

confidence: 99%

Tailored Functionalization of Natural Phenols to Improve Biological Activity

et al. 2021

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“…Eugenol is said to possess various biological properties like antiseptic, analgesic, and antibacterial properties. [8][9][10][11][12][13] Besides its potential applications in treating some diseases, it has been studied in terms of its anti-inammatory, antioxidant, antispasmodic, antidepressive, antigenotoxic, and anticarcinogenic properties. [14][15][16] Further studies are needed to determine the signal transduction pathways that are blocked and activated by the immune system to determine how eugenol inhibits inammation.…”

Section: Introductionmentioning

confidence: 99%

“…Eugenol is said to possess various biological properties like antiseptic, analgesic, and antibacterial properties. 8–13 Besides its potential applications in treating some diseases, it has been studied in terms of its anti-inflammatory, antioxidant, antispasmodic, antidepressive, antigenotoxic, and anticarcinogenic properties. 14–16…”

Section: Introductionmentioning

confidence: 99%

Novel derivatives of eugenol as potent anti-inflammatory agents via PPARγ agonism: rational design, synthesis, analysis, PPARγ protein binding assay and computational studies

Anjum¹,

Shanmugarajan

Shivaraju

et al. 2022

RSC Adv.

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“…[32 -33] Biological evaluations showed the antifungal potential of these derivatives against plant pathogenic oomycetes of Phytophthora capsici, which highlights these compounds as examples of greenfungicides. Anjum et al [34] reported the antimicrobial, anti-inflammatory, antioxidant and anticancer potential of semi-synthetic compounds prepared from eugenol. Arenas et al [35] demonstrated that eugenol can be a good starting material in the preparation of substances with optimised oxidising action.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Structure‐Activity Relationship Studies of Novel Aryl Sulfonamides and Their Activity against Human Breast Cancer Cell Lines

Azevedo-Barbosa

Ferreira-Silva

Vale

et al. 2022

Chemistry & Biodiversity

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A series of structural analogs of aryl sulfonamide hybrid compounds were synthesised and their cytotoxic activity was evaluated against three human breast cancer cell lines (MCF‐7, MDA‐MB‐231 and Hs 578T). The compounds were designed through electronic, hydrophobic and steric modifications using the chemical structure of N‐{4‐[(2‐hydroxy‐3‐methoxy‐5‐propylphenyl)sulfamoyl]phenyl}acetamide (referred to as compound 7) as a starting point to then assess a structure‐activity relationship (SAR) study. From the data generated, we observed that compounds 9, 10 and 11 (which have modifications in the substituents of the aryl sulfonamide), efficiently reduced the cell viability of MCF‐7 and MDA‐MB‐231 cell cultures. Based on initial data, we selected compounds 10 and 11 for further investigations into their antiproliferative and/or cytotoxic profile against MDA‐MB‐231 cells, and we noted that compound 10 was the most promising compound in the series. Compound 10 promoted morphological changes and altered the dynamics of cell cycle progression in MDA‐MB‐231 cells, inducing arrest in G1/S transition. Taken together, these results show that the dihydroeugenol‐aryl‐sulfonamide hybrid compound 10 (which has an electron withdrawing nitro group) displays promising antiproliferative activity against MDA‐MB‐231 cell lines.

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Semisynthetic Derivatives of Eugenol and their Biological Properties: A Fleeting Look at the Promising Molecules

Cited by 3 publications

References 48 publications

Tailored Functionalization of Natural Phenols to Improve Biological Activity

Tailored Functionalization of Natural Phenols to Improve Biological Activity

Novel derivatives of eugenol as potent anti-inflammatory agents via PPARγ agonism: rational design, synthesis, analysis, PPARγ protein binding assay and computational studies

Synthesis and Structure‐Activity Relationship Studies of Novel Aryl Sulfonamides and Their Activity against Human Breast Cancer Cell Lines

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