Abstract:A series of structural analogs of aryl sulfonamide hybrid compounds were synthesised and their cytotoxic activity was evaluated against three human breast cancer cell lines (MCF‐7, MDA‐MB‐231 and Hs 578T). The compounds were designed through electronic, hydrophobic and steric modifications using the chemical structure of N‐{4‐[(2‐hydroxy‐3‐methoxy‐5‐propylphenyl)sulfamoyl]phenyl}acetamide (referred to as compound 7) as a starting point to then assess a structure‐activity relationship (SAR) study. From the data… Show more
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