Semisolid Dosage

Lunter, Dominique Jasmin; Daniels, Rolf

doi:10.3390/pharmaceutics12040315

Cited by 1 publication

(6 citation statements)

References 12 publications

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“…Further, it becomes clear that the formulation with enhancer delivers more procaine to the stratum corneum than the formulation without enhancer. This is in line with previous findings 2 …”

Section: Resultssupporting

confidence: 94%

“…HPMC poloxamer gels were prepared according to the method published by Shin et al 14 The method is also described in our previous publications 2‐4 . The formulation without penetration enhancer contained 7 g of procaine HCl, 0.2 g of HPMC, and 2 g of poloxamer 407 in 10‐g water.…”

Section: Methodsmentioning

confidence: 99%

“…Incubation lasted for 14 hr and was performed at 32°C under constant stirring. The exact procedures are described in previous publications 15‐20 …”

Section: Methodsmentioning

confidence: 99%

“…Confocal Raman microspectroscopy has been increasingly used in the past years to investigate the skin penetration of pharmaceutical or cosmetic actives and excipients 1‐6 . It makes use of the characteristic Raman spectrum of the penetrating substance to monitor its relative concentration across the skin depth and thus does not require any labels, which might interfere with skin penetration.…”

Section: Introductionmentioning

confidence: 99%

“…In pharmaceutical research, it is for example used to analyse the drug distribution in tablets or to investigate the inner structure of semisolids 10‐12 . It can also be utilised to analyse biological samples and to monitor skin penetration 2‐4, 13 …”

Section: Introductionmentioning

confidence: 99%

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Determination of skin penetration profiles by confocal Raman microspectroscopy: Evaluation of interindividual variability and interlab comparability

Binder

Valenta

Lunter

2020

J Raman Spectroscopy

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Confocal Raman microspectroscopy is being increasingly used to investigate the skin penetration of actives and excipients. The aim of the present study was to compare results obtained with skin from different donors, acquired with two Raman systems: the RiverD gen2 Skin Composition Analyzer and the WiTec alpha 500 instrument. To elucidate the interindividual variability between the skin donors and to find out whether the two systems would give similar results in skin penetration analysis, we compared the penetration of the model drug procaine from hydrogel formulations with or without the penetration enhancer POE‐23‐lauryl ether. Penetration was investigated with both systems on skin from three different skin donors, each. Penetration plots were prepared by plotting the signal intensity of a typical peak of procaine against the skin depth. We then calculated the enhancement ratio from the areas under the curves of the penetration plots of procaine that had penetrated from the formulation with or without the enhancer. They ranged between 2.0 and 3.1 for the WiTec system and between 2.1 and 3.1 for the RiverD system. Thus, we found that both systems provide similar estimations of the skin penetration of procaine.

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“…Further, it becomes clear that the formulation with enhancer delivers more procaine to the stratum corneum than the formulation without enhancer. This is in line with previous findings 2 …”

Section: Resultssupporting

confidence: 94%

Section: Methodsmentioning

confidence: 99%

“…Incubation lasted for 14 hr and was performed at 32°C under constant stirring. The exact procedures are described in previous publications 15‐20 …”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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