Seminal vesicles

Bostwick, David G.

doi:10.1016/b978-0-323-01970-5.50012-9

Cited by 10 publications

(10 citation statements)

References 144 publications

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“…Leiomyosarcoma, a malignant mesenchymal neoplasm exhibiting smooth muscle differentiation at the light microscopic and ultrastructural level, is the most common sarcoma of the urinary bladder,1 although it comprises less than 1% of all malignancies in this anatomical location 2 3. Leiomyosarcomas of the urinary bladder (LMS-UB) most often occur in middle-aged to elderly adults, with a slight male predominance, and frequently present with gross haematuria, dysuria and abdominal pain 4–6.…”

Section: Introductionmentioning

confidence: 99%

Leiomyosarcoma of the urinary bladder: a clinicopathological study of 34 cases

Lindberg¹,

Fisher²,

Thway³

et al. 2010

J Clin Pathol

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Section: Introductionmentioning

confidence: 99%

Leiomyosarcoma of the urinary bladder: a clinicopathological study of 34 cases

Lindberg¹,

Fisher²,

Thway³

et al. 2010

J Clin Pathol

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“…Scattered large atypical cells with hyperchromatic nuclei can be seen in elderly males called monstrous cells, which can mimic a tumourous cell. The IHC profile of lining cells shows positivity for AE1/AE3, CK7, p63, CA‐125 and PAX 8, and negativity for PSA, CK20, CDX‐2 and AMACR (Bostwick, ). GATA3 expression has been described in one of the recent reports (Ortiz‐Rey, Chantada‐de la Fuente, Peteiro‐Cancelo, Gómez‐de María, & San Miguel‐Fraile, ) in the normal seminal vesicle epithelium (although no reports in seminal vesicle adenocarcinoma, probably due to its rarity).…”

Section: Discussionmentioning

confidence: 97%

“…They often present clinically with hematospermia and/or obstructive uropathy (Katafigiotis et al, ). They have poor survival of <3 years in about 95% of the patients (Bostwick, ). Some of these have a questionable diagnosis of histopathology owing to lack of specific IHC marker.…”

Section: Discussionmentioning

confidence: 99%

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Primary seminal vesicle adenocarcinoma: A case report of rare entity and discussion of its differential diagnosis using immunohistochemical approach for the core biopsy specimen

et al. 2020

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Primary seminal vesicle adenocarcinoma is a rare malignancy of the male genito‐urinary system with only a few confirmed reported cases. Initial tissue diagnostic modality is often a core biopsy specimen. Here, we report this rare entity in a 50‐year‐old male, highlighting the histomorphological and immunohistochemical approach to the core biopsy specimen of the seminal vesicle mass. The patient presented with a history of haematospermia and gross haematuria for one year, and radiological workup was found to have a right seminal vesicle mass. A trans‐rectal ultrasound guided core biopsy revealed a tumourous lesion with a predominant papillary architecture and cytological features of neoplasia. Based on positivity for CK7, PAX‐8 and CA‐125, and Ki‐67 index of 30%–40% and negativity for PSA, AMACR, CK20, CDX‐2, p63, GATA3, WT1 and calretinin, a diagnosis of primary seminal vesicle adenocarcinoma was offered. The diagnosis was also confirmed on the surgically resected specimen. This case depicts the approach of a pathologist to diagnose this rare entity on the core biopsy specimen and the possible differential diagnoses one must consider.

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“…In addition, immunohistochemical stains were positive for cytokeratin, epithelial membrane antigen, and vimentin, but negative for smooth muscle actin. Therefore, it was diagnosed as MCDK coexistent with MRTK (11). By electron microscopy, tumor cells of usual cases of MRTK form sheetlike patterns, have poorly formed intercellular junctions, abundant mitochondria, and lipid droplets in the cytoplasm, especially prominent aggregates of filaments.…”

Section: Discussionmentioning

confidence: 99%

Malignant Rhabdoid Tumor of the Kidney Combined with Multicystic Dysplasia in a 5-year-old Child

et al. 2010

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Multicystic dysplastic kidney (MCDK) is a relatively common developmental anomaly in infants and children and has a good prognosis. In contrast, a malignant rhabdoid tumor of the kidney (MRTK) is one of the most lethal neoplasms of early life. However, the presentation of such a lethal tumor combined with multicystic dysplasia has not been reported to date. In this report, we describe a case of MRTK in a 5-yr-old girl who also had multicystic dysplasia. She was previously diagnosed with MCDK at birth due to a huge palpable mass on the right side of the abdomen. The right kidney was extensively replaced by numerous grossly dilated, variable-sized cysts. Microscopically, the tumor cells show a diffusely infiltrative growth pattern, which revealed large non-cohesive, round-to-polygonal tumor cells with vesicular nuclei. Some tumor cells had eccentric nuclei and large, round, eosinophilic cytoplasmic inclusions. There were metanephrons present, with the central ureteric bud and peripheral branches surrounded by condensing mesenchyma, immature glomeruli, and metaplastic cartilage in the adjacent parenchyma. To our knowledge, this is the first combined case of the two aforementioned diseases and this case may, in fact, suggest a new disease entity.

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Seminal vesicles

Cited by 10 publications

References 144 publications

Leiomyosarcoma of the urinary bladder: a clinicopathological study of 34 cases

Leiomyosarcoma of the urinary bladder: a clinicopathological study of 34 cases

Primary seminal vesicle adenocarcinoma: A case report of rare entity and discussion of its differential diagnosis using immunohistochemical approach for the core biopsy specimen

Malignant Rhabdoid Tumor of the Kidney Combined with Multicystic Dysplasia in a 5-year-old Child

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