Primary seminal vesicle adenocarcinoma: A case report of rare entity and discussion of its differential diagnosis using immunohistochemical approach for the core biopsy specimen

Abstract

Primary seminal vesicle adenocarcinoma is a rare malignancy of the male genito‐urinary system with only a few confirmed reported cases. Initial tissue diagnostic modality is often a core biopsy specimen. Here, we report this rare entity in a 50‐year‐old male, highlighting the histomorphological and immunohistochemical approach to the core biopsy specimen of the seminal vesicle mass. The patient presented with a history of haematospermia and gross haematuria for one year, and radiological workup was found to have a right seminal vesicle mass. A trans‐rectal ultrasound guided core biopsy revealed a tumourous lesion with a predominant papillary architecture and cytological features of neoplasia. Based on positivity for CK7, PAX‐8 and CA‐125, and Ki‐67 index of 30%–40% and negativity for PSA, AMACR, CK20, CDX‐2, p63, GATA3, WT1 and calretinin, a diagnosis of primary seminal vesicle adenocarcinoma was offered. The diagnosis was also confirmed on the surgically resected specimen. This case depicts the approach of a pathologist to diagnose this rare entity on the core biopsy specimen and the possible differential diagnoses one must consider.

Total pelvic exenteration for mucinous adenocarcinoma arising from an implantation cyst 26 years after surgery for rectal cancer

“…Our case showed implantation cyst 24 years after the primary operation, and pathological findings revealed that the primary rectal cancer was a moderately differentiated adenocarcinoma, whereas the second adenocarcinoma arising from the implantation cyst was mucinous adenocarcinoma. Additionally, the tumor was found to be positive for CDX2, a characteristic that can differentiate it from a malignancy originating from the seminal vesicle, which demonstrates a negative CDX2 status 8 . Altogether, our case was not a local recurrence, but a secondary malignant formation from an implantation cyst at the anastomotic site.…”

“…Additionally, the tumor was found to be positive for CDX2, a characteristic that can differentiate it from a malignancy originating from the seminal vesicle, which demonstrates a negative CDX2 status. 8 Altogether, our case was not a local recurrence, but a secondary malignant formation from an implantation cyst at the anastomotic site.…”

Validation of the Rat Model of Prostate Cancer: Correlating Seminal Vesicle Lesions With Dorsolateral Prostate Lesions

“…Externally, there is an adventitial layer composed of loose areolar tissue (2,3). Primary adenocarcinoma of seminal vesicles are rare but neoplastic lesions spreading from adjacent organs such as the prostate, urinary bladder and rectum are commonly observed (4,5). Seminal vesicles play a key role in sperm synthesis, consequently diseases affecting this gland result in male infertility.…”