Seminal vesicle involvement after radical prostatectomy: predicting risk factors for progression

Salomon, Laurent; Anastasiadis, Aristotelis G.; Johnson, Christopher W.; McKiernan, James M.; Goluboff, Erik T.; Abbou, Claude C.; Olsson, Carl A.; Benson, Mitchell C.

doi:10.1016/s0090-4295(03)00373-x

Cited by 60 publications

(51 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1 Furthermore, ECE and SVI (stages pT3a and pT3b, respectively) are associated with a poor prognosis. 2 According to the 2002 TNM staging system, 3 BNI is classified currently as stage pT4 disease; nevertheless, the outcome of subjects with microscopic BNI and otherwise organ-confined disease does not appear to be similar to that of patients with PCa involving the rectum or the external sphincter. [5][6][7] To our knowledge, this is the largest cohort of patients with clinically localized PCa and BNI (stage pT4) demonstrated on pathological analysis.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Invasion of bladder neck after radical prostatectomy: one definition for different outcomes

Rodríguez-Covarrubias

Larré

Dahan

et al. 2007

Prostate Cancer Prostatic Dis

View full text Add to dashboard Cite

The aim of the study was to evaluate factors of progression after radical prostatectomy in patients with bladder neck invasion (BNI). From 1988 to 2006, 1395 patients underwent radical prostatectomy, 120 (8.6%) had microscopic BNI (pT4 N0, TNM 2002). Group 1 was defined as BNI alone, group 2 as BNI plus extracapsular extension and group 3 as BNI plus seminal vesicle invasion (SVI). Postoperative follow-up data were obtained through routine serum prostate-specific antigen (PSA) and digital rectal examination. Biochemical progression was defined as a single detectable PSA level postoperatively (40.2 ng ml À1). Groups 1, 2 and 3 included 38 (31%), 35 (30%) and 47 (39%) patients, respectively. Preoperative PSA (11.1 vs 24.7 and 23.3 ng ml À1 , P ¼ 0.01), biopsy Gleason score (5 vs 6 and 6, P ¼ 0.003) and specimen Gleason score (6 vs 7 and 7, P ¼ 0.02) were statistically different between three groups. None of the patients had a specimen Gleason score X8 in group 1. After a mean follow-up of 27 months, 51 (42.5%) patients had biochemical progression.The 5-year progression-free survival was 87, 53 and 17% for groups 1, 2 and 3, respectively (Po0.001). Within pT4 prostate cancer, those tumors with isolated microscopic BNI appear to have better prognosis than those with associated extracapsular extension and/or seminal vesicle invasion, and should be distinguished in TNM classification.

show abstract

Section: Discussionmentioning

confidence: 99%

“…1 Furthermore, extracapsular extension (ECE) and seminal vesicle invasion (SVI) are associated with a poor prognosis. 2 According to the American Joint Committee on Cancer TNM 2002 staging system, 3 pT4 category includes tumors invading adjacent organs. Thus, bladder neck invasion (BNI) by PCa is considered within this category.…”

Section: Introductionmentioning

confidence: 99%

Invasion of bladder neck after radical prostatectomy: one definition for different outcomes

Rodríguez-Covarrubias

Larré

Dahan

et al. 2007

Prostate Cancer Prostatic Dis

View full text Add to dashboard Cite

show abstract

“…The 10 year metastasis free survival was 57%. In a smaller combined study (33), 137 SV positive patients were followed for a median of 4.9 years. Fifty two percent fa ile d (P SA >0.…”

Section: Seminal Vesicle and Lymph Node Positivementioning

confidence: 99%

Prognostic Factors for Failure after Prostatectomy

Swanson¹,

Basler²

2011

J. Cancer

View full text Add to dashboard Cite

“…However, there was no significant association between RM2 expression and seminal vesicle invasion, one of the poor prognostic factors. 4,25 Regarding this point, the expression level of RM2 antigen and seminal vesicle invasion may represent different aspects of the malignant potential of prostate cancer, respectively.…”

Section: Discussionmentioning

confidence: 99%

RM2 antigen (β1,4‐GalNAc‐disialyl‐Lc₄) as a new marker for prostate cancer

Saitoh

Egawa

Endoh

et al. 2005

Intl Journal of Cancer

View full text Add to dashboard Cite

Although prostate-specific antigen (PSA) has been widely used for early detection of prostate cancer, PSA has problems with specificity and prediction of pathological stage. Therefore, a new marker for prostate cancer is urgently required. We examined expression of a novel carbohydrate antigen, b1,4-GalNAc-disialyl-Lc 4 , defined by the monoclonal antibody RM2, in prostate cancer using 75 cases of radical prostatectomy specimens. RM2 immunoreactivity was negative to weak in all benign glands, and weak to moderate in high-grade prostatic intraepithelial neoplasia. In prostatic adenocarcinoma, RM2 immunoreactivity was negative to weak (lower expression) in 20 cases, and moderate to strong (higher expression) in 55 cases. A clear difference of RM2 expression level was observed between Gleason patterns 3 and !4. Higher expression of RM2 antigen was significantly associated with primary Gleason pattern !4, high Gleason score (!8), larger tumor volume and advanced tumor stage. Furthermore, 5-year PSA failurefree survival was significantly lower in the higher expression group. However, no significant relationship was observed between RM2 expression level and preoperative serum PSA. Western blot analysis in prostate cancer cell lines PC3 and LNCap revealed that major 49-kDa and minor 39-kDa glycoproteins were common to both cells, but there was an increase of 59-and 125-kDa glycoproteins unique to LNCap and an increase of 88-and 98-kDa glycoproteins unique to PC3. RM2 antigen is a new histological marker for prostate cancer that may reflect the Gleason grading system. Identification of the glycoproteins carrying the RM2 antigen will provide new insights into the properties of prostate cancer. ' 2005 Wiley-Liss, Inc.

show abstract

Seminal vesicle involvement after radical prostatectomy: predicting risk factors for progression

Cited by 60 publications

References 25 publications

Invasion of bladder neck after radical prostatectomy: one definition for different outcomes

Invasion of bladder neck after radical prostatectomy: one definition for different outcomes

Prognostic Factors for Failure after Prostatectomy

RM2 antigen (β1,4‐GalNAc‐disialyl‐Lc₄) as a new marker for prostate cancer

Contact Info

Product

Resources

About

Seminal vesicle involvement after radical prostatectomy: predicting risk factors for progression

Cited by 60 publications

References 25 publications

Invasion of bladder neck after radical prostatectomy: one definition for different outcomes

Invasion of bladder neck after radical prostatectomy: one definition for different outcomes

Prognostic Factors for Failure after Prostatectomy

RM2 antigen (β1,4‐GalNAc‐disialyl‐Lc4) as a new marker for prostate cancer

Contact Info

Product

Resources

About

RM2 antigen (β1,4‐GalNAc‐disialyl‐Lc₄) as a new marker for prostate cancer