Seminal oestrogens in the boar: Origin and functions in the sow

Claus, R.; Hoang-Vu, C.; Ellendorff, Franz; Meyer, H. H. D.; Schopper, Doris; Weiler, Ulrike

doi:10.1016/0022-4731(87)90324-4

Cited by 64 publications

(22 citation statements)

References 17 publications

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“…In the present study, PR ratios from image analyses were higher in the glandular epithelium of inseminated sows at 5 -6 h after AI than in non-inseminated sows at oestrus which might be an effect by insemination. As the semen from boars contains high levels of oestrogen (Claus et al 1987) it could act locally on the endometrium in addition to plasma oestradiol-17b and result in the upregulation of glandular PR.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical studies on the progesterone receptor (PR) in the sow uterus during the oestrous cycle and in inseminated sows at oestrus and early pregnancy

Sukjumlong¹,

Dalin²,

Sahlin³

et al. 2005

Reproduction

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Physiological changes in the sow uterus involve the regulation by progesterone and its receptor proteins (PR). Therefore, the aim of the present study was to investigate the localization of PR during different stages of the oestrous cycle and in inseminated sows during early pregnancy by use of immunohistochemistry. Uterine samples were collected from cyclic and inseminated sows at different stages of the oestrous cycle and early pregnancy. The samples were fixed in 10% formaldehyde and embedded in paraffin. Immunohistochemistry was done by use of a mouse monoclonal antibody to PR. The highest PR immunostaining in the surface epithelium was observed at oestrus/5 -6 h after artificial insemination (AI) and early dioestrus/70 h after AI. In the glandular epithelium, the highest level of PR was found at oestrus with the lowest at late dioestrus/d 19. Higher levels of PR were observed in inseminated groups compared with cyclic sows. In the myometrium, a high level of PR was found at oestrus, while stromal PR cells were constantly present throughout the oestrous cycle and at different stages of early pregnancy. In conclusion, this study shows that the immunopresence of PR in the sow uterus differed between uterine compartments at the same reproductive stage. Differences were also found for some uterine compartments between cyclic and inseminated/early pregnant sows. The relatively consistent immunostaining of PR in the stroma strengthens a stromal role in the regulation of physiological activities in the sow uterus during the oestrous cycle as well as early pregnancy.

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Section: Discussionmentioning

confidence: 99%

Immunohistochemical studies on the progesterone receptor (PR) in the sow uterus during the oestrous cycle and in inseminated sows at oestrus and early pregnancy

Sukjumlong¹,

Dalin²,

Sahlin³

et al. 2005

Reproduction

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“…PGs have pleiotrophic effects in pregnancy and have the potential to influence maternal immune responses , embryo development (Claus et al 1987) and ovarian function (Armstrong 1981, Christenson et al 1994. Most notable is the role of PGF 2a and PGE 2 in the maternal recognition of pregnancy, particularly in view of studies indicating the importance of PGF 2a synthesised by the uterine endometrium (Bazer & Thatcher 1977) and potentially transferred to the ovary by a counter-current mechanism facilitated by close apposition of the uterine venous net to the ovarian artery (Krzymowski et al 1989).…”

Section: Pbs Spmentioning

confidence: 99%

Seminal plasma regulates endometrial cytokine expression, leukocyte recruitment and embryo development in the pig

O’Leary¹,

Jasper²,

Warnes³

et al. 2004

Reproduction

212

179

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In pigs, uterine exposure to the constituents of semen is known to increase litter size but the underlying physiological mechanisms remain undefined. Studies in rodents and humans implicate immune modulating moieties in seminal plasma as likely candidates, acting through enhancing the receptivity of the female tract. In this study, the acute and longer term effects of seminal plasma on cytokine expression and leukocyte abundance in the pig endometrium during early pregnancy have been characterised. The reproductive tracts of gonadotrophin-primed pre-pubertal gilts treated with intrauterine infusions of either pooled seminal plasma or phosphate-buffered saline (PBS) were retrieved at 34 h, or on day 5 and day 9 after treatment. Seminal plasma elicited an endometrial inflammatory infiltrate comprised of predominantly macrophages and major histocompatibility complex class II 1 -activated macrophages and dendritic cells. The abundance of these cells was greatest at the pre-ovulatory (34 h) time-point and their increase relative to PBS-treated tissues was maintained until day 9 after seminal plasma treatment. Seminal plasma induced the expression of the cytokines, granulocyte macrophage colony-stimulating factor, interleukin-6 and monocyte chemoattractant protein-1, and the eicosanoid-synthesising enzyme cyclo-oxygenase-2. Expression was maximal 34 h after treatment but altered expression patterns as a consequence of seminal plasma induction persisted through early pregnancy. These changes were accompanied by altered dynamics in pre-implantation embryo development with an increase in the number of embryos and in their viability after seminal plasma treatment. Together, these findings implicate factors in seminal plasma in programming the trajectory of uterine cytokine expression and leukocyte trafficking during early pregnancy and in regulating pre-implantation embryo development in the pig.

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“…In contrary, Claus et al (1983Claus et al ( , 1985 found higher concentrations of unconjugated oestrogens in seminal plasma compared to blood plasma. Oestrogens from boar semen increase the myometrial contraction frequency in the sows by stimulation of PGF2α release (Claus et al 1987, Claus 1990). They influence also LH release and contribute to the timing of ovulation in response to mating or insemination (Claus 1990, Weiler and Claus 1991, Waberski et al 1996.…”

Section: Discussionmentioning

confidence: 99%

Concentrations of oestrogens in blood plasma and seminal plasma of boars during the postpuberal period

Zduńczyk¹,

Janowski²,

Raś³

et al. 2011

Polish Journal of Veterinary Sciences

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Concentrations of oestrogens in the blood plasma and seminal plasma of mature boars are high. However, little is known about their concentrations after reaching sexual maturity. The aim of this study was to determine the concentration of oestrogens in blood plasma and seminal plasma of boars during the postpuberal period. Free and conjugated oestrone and oestradiol-17β were determined by radioimmunoassay in blood from the testicular vein and artery, and peripheral circulation as well as in seminal plasma collected from 18 Polish Landrace boars. The animals were divided into three groups (n = 6) according to age (8, 12 and 16 months, respectively). Oestrone was predominant free and conjugated oestrogen. The highest values of oestrogens were measured in the testicular vein (p ≤ 0.05). The concentrations of oestrogens in seminal plasma did not differ from those found in the peripheral circulation. An age-dependent increase in levels of all four oestrogens (p ≤ 0.05) was observed. This can be associated with biochemical maturation of the reproductive system during the postpuberal period.

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Seminal oestrogens in the boar: Origin and functions in the sow

Cited by 64 publications

References 17 publications

Immunohistochemical studies on the progesterone receptor (PR) in the sow uterus during the oestrous cycle and in inseminated sows at oestrus and early pregnancy

Immunohistochemical studies on the progesterone receptor (PR) in the sow uterus during the oestrous cycle and in inseminated sows at oestrus and early pregnancy

Seminal plasma regulates endometrial cytokine expression, leukocyte recruitment and embryo development in the pig

Concentrations of oestrogens in blood plasma and seminal plasma of boars during the postpuberal period

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