Seminal fructose in normal and infertile men

Rajalakshmi, M.; Sharma, R.; Dávid, Gyula; Kapur, M. M.

doi:10.1016/0010-7824(89)90062-0

Cited by 16 publications

(15 citation statements)

References 5 publications

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“…Rajalakshmi et al . (1989) have demonstrated that fructolysis is very low when spermatozoa have poor motility.…”

Section: Discussionmentioning

confidence: 99%

“…Despite that, the measurement of seminal fructose is used as a marker of the seminal vesicle function. Rajalakshmi et al (1989) have demonstrated that fructolysis is very low when spermatozoa have poor motility. This suggests that fructose is used mainly by motile spermatozoa.…”

Section: Discussionmentioning

confidence: 99%

“…In semen samples it is possible to find motile as well as immotile spermatozoa. It has been observed that seminal fructose concentration inversely correlates with motile spermatozoa (Rajalakshmi et al ., 1989; Lewis‐Jones et al ., 1996). Spermatozoa with poor or absent motility do not use fructose (Lewis‐Jones et al ., 1996), therefore, seminal fructose should be corrected for motile sperm concentration and not for motile plus non‐motile sperm concentration as it was used for the calculation of corrected fructose (Gonzales & Villena, 1997).…”

Section: Introductionmentioning

confidence: 99%

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True corrected seminal fructose level: a better marker of the function of seminal vesicles in infertile men

Gonzales

Villena

2001

Int J of Andrology

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This study was designed to determine if the value obtained after multiplying motile sperm concentration by seminal fructose concentration, named "true corrected fructose", correlates with sperm motility in asthenozoospermic men. Forty-two male partners in infertile couples were studied. Men were treated with 100 mg daily of clomiphene citrate for 5 days. Blood and semen samples were collected before treatment and 24 h after the end of treatment. Serum testosterone, seminal fructose and sperm motility were measured in each subject. Corrected fructose (log. sperm concentration multiplied by seminal fructose), and true corrected fructose (log. motile sperm concentration multiplied by seminal fructose) values were calculated. Prevalence of asthenozoospermia was 42.85% (18 of 42). Prevalence of hypofunction of the seminal vesicles was 9.5% using seminal fructose as a marker; 40.5% using seminal corrected fructose as a marker and 47.6% using true corrected fructose as a marker of seminal vesicle function. Regression analysis showed a better coefficient of determination between true corrected fructose and motile sperm concentration (R2=0.20, p < 0.001) than with corrected fructose (R(2)=0.05, p < 0.1) or fructose concentration (R(2)=0.006, p < 0.5). Asthenozoospermia was observed in 22.7% of subjects with normal function of the seminal vesicles, and in 65% of men with low values of true corrected fructose (z=6.02, p < 0.0001). Multivariate analysis showed that sperm motility grade 3 improved after treatment with clomiphene if true corrected fructose increased (p < 0.002). In those men whose seminal vesicle function improved after clomiphene treatment, a reduction in the prevalence of asthenozoospermia from 50 to 28.6% (z=3.10, p < 0.002) was observed whereas in those whose seminal vesicles did not respond to clomiphene the prevalence of asthenozoospermia was not reduced (z=1.05; p: NS). In conclusion, true corrected fructose measurement relates with sperm motility in cases of asthenozoospermia. Asthenozoospermia improves with clomiphene treatment if seminal vesicle function improves after treatment.

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“…Rajalakshmi et al . (1989) have demonstrated that fructolysis is very low when spermatozoa have poor motility.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

True corrected seminal fructose level: a better marker of the function of seminal vesicles in infertile men

Gonzales

Villena

2001

Int J of Andrology

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“…10,11 The role of fructose concentrations in seminal plasma for total and sperm density has been investigated by several authors. Rajalakhshmi M, et al, 12 and Gonzales 13 reported that an increase in sperm concentration is often accompanied by a decrease in fructose concentration in seminal plasma, because sperm using fructose as the primary source of energy, 12,13 However, others studies have also shown that fructose concentrations in seminal plasma of patients with oligozoospermia and azoospermia did not decrease as compared to normal men.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the level of seminal zinc and fructose concentration in seminal plasma of Vietnamese infertile men

Trang¹,

Sang²,

Hoàng³

et al. 2018

MOJBOC

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“…Surgery was done with 1% xylocaine on one side at a time (Rajalakshmi et al, 1989(Rajalakshmi et al, , 1990. In brief, the testis and epididymis were exposed by a scrota1 incision and the presence of epididymal tubule with fluid containing spermatozoa was confirmed under an operating microscope; side to side anastomosis of the epididymal tubule above the site of obstruction with the vas deferens was done using 6-0 prolene sutures.…”

Section: Methodsmentioning

confidence: 99%

Ultrastructural changes in the efferent duct and epididymis of men with obstructive infertility

et al. 1993

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Ultrastructural changes in the efferent duct and in different regions of the epididymis in men with obstructive azoospermia were compared with corresponding tissues collected from men of proven fertility who underwent castration due to malignancy of the prostate. Major degenerative changes were seen in the efferent duct and the caput epididymidis of men with obstruction at the caput epididymidis which may have been induced by fluid pressure due to defective absorption of testicular fluid in the caput epididymidis. These degenerative changes included decrease in tubular and lumen diameter of the caput and the cauda epididymides, decrease in height of the stereocilia, reduction in rough endoplasmic reticulum and Golgi material, and presence of lipofuscin and osmiophilic dense bodies. The degenerative changes were less when the site of obstruction was in the cauda epididymidis since fluid reabsorption would continue to take place normally in the caput epididymidis. In men who had undergone vasoepididymostomy (VEA), the ejaculated spermatozoa showed a high percentage of morphological abnormalities which may have occurred due to adverse effects of long-term obstruction on spermatogenesis.

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Seminal fructose in normal and infertile men

Cited by 16 publications

References 5 publications

True corrected seminal fructose level: a better marker of the function of seminal vesicles in infertile men

True corrected seminal fructose level: a better marker of the function of seminal vesicles in infertile men

Assessment of the level of seminal zinc and fructose concentration in seminal plasma of Vietnamese infertile men

Ultrastructural changes in the efferent duct and epididymis of men with obstructive infertility

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