Semicircular lipoatrophy after intragluteal injection of benzathine penicillin

Lipodystrophy in Patients with Acromegaly Receiving Pegvisomant

“…Before the advent of recombinant insulin, lipoatrophy was commonly associated with insulin administration, likely attributable to a local immune reaction to crystals of impure insulin preparations (9). Localized lipoatrophy has been reported as a complication of im injection of benzathine penicillin (10,11) and steroids (11). After administration of sc octreotide for 2-6 yr (12), three female patients with acromegaly developed injection-site lipoatrophy (upper arms, thighs, and abdomen).…”

Partial Lipoatrophy in a Child

“…Localized lipoatrophy occurs in different clinical scenarios including panatrophy of Gowers, annular atrophy of the ankles (1), annular lipoatrophy, abdominal lipoatrophy, semicircular lipoatrophy, and localized postinjection lipoatrophy (2). Postinjection lipoatrophy can occur following injection of substances such as corticosteroids, iron dextran, diphtheria-pertussis-tetanus vaccine, insulin (3), and benzathine penicillin (4). Our case exemplifies the latter example.…”

Localized lipoatrophy after intramuscular amikacin

“…Localized lipoatrophy may be seen following connective tissue diseases, such as, lupus erythematosus, morphea, dermatomyositis, and overlap syndrome disease; neoplasms, such as T-cell lymphoma; drug injections, such as corticosteroids, benzathine penicillin, insulin, methotrexate, vasopressin, growth hormone, glatiramer acetate, copolymer 1, iron dextran, and DPT vaccine (drugs in order of reported frequency); or as primary idiopathic lipoatrophy. [1][2][3][5][6][7] Localized lipoatrophy may represent the end-stage of panniculitis in a localized expression of connective tissue disease. [8] Thus ANA, anti-ds-DNA, anti-Sm, and anti-U1-RNP immunoassay should be performed in all cases of localized lipoatrophy.…”

“…Drugs that have been implicated in the pathogenesis of lipoatrophy are insulin, penicillin, and corticosteroids. [1][2][3] We report two cases of acquired localized lipoatrophy after multiple intramuscular injections of amikacin, which have not been reported in the literature yet. A detailed history and examination did not reveal any antecedent cause of lipoatrophy in both cases.…”