Semi-synthesis of hybrid ulvan-kappa-carrabiose polysaccharides and evaluation of their cytotoxic and anticoagulant effects

Colodi, Franciely Grose; Ducatti, Diogo R.B.; Noseda, Miguel D.; Carvalho, Mariana M. de; Winnischofer, Sheila Maria Brochado; Duarte, Maria Eugênia R.

doi:10.1016/j.carbpol.2021.118161

Cited by 8 publications

(6 citation statements)

References 44 publications

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“…Ulvan polysaccharide is a biologically active natural sulfated polysaccharide with excellent properties such as antibacterial [ 58 ], antioxidant [ 59 ], antiviral [ 60 ], and hypolipidemic activity [ 61 ]. Ulvan polysaccharide mainly consists of rhamnose 3-sulfate, xylose-2-sulfate, and glucuronic acid, and is widely used as a raw material for the preparation of hydrogels [ 62 ]. Ulvan polysaccharide contains hydroxyl groups that can form hydrogen bonds, producing gel-like properties [ 63 ].…”

Section: Polysaccharidementioning

confidence: 99%

Polysaccharide-Based Transdermal Drug Delivery

Xiang

Zhang

et al. 2022

Pharmaceuticals

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Materials derived from natural plants and animals have great potential for transdermal drug delivery. Polysaccharides are widely derived from marine, herbal, and microbial sources. Compared with synthetic polymers, polysaccharides have the advantages of non-toxicity and biodegradability, ease of modification, biocompatibility, targeting, and antibacterial properties. Currently, polysaccharide-based transdermal drug delivery vehicles, such as hydrogel, film, microneedle (MN), and tissue scaffolds are being developed. The addition of polysaccharides allows these vehicles to exhibit better-swelling properties, mechanical strength, tensile strength, etc. Due to the stratum corneum’s resistance, the transdermal drug delivery system cannot deliver drugs as efficiently as desired. The charge and hydration of polysaccharides allow them to react with the skin and promote drug penetration. In addition, polysaccharide-based nanotechnology enhances drug utilization efficiency. Various diseases are currently treated by polysaccharide-based transdermal drug delivery devices and exhibit promising futures. The most current knowledge on these excellent materials will be thoroughly discussed by reviewing polysaccharide-based transdermal drug delivery strategies.

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Section: Polysaccharidementioning

confidence: 99%

Polysaccharide-Based Transdermal Drug Delivery

Xiang

Zhang

et al. 2022

Pharmaceuticals

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“…Thus, biocompatibility evaluation is an important indicator of the safety of drug delivery systems and scaffolds. The assessment applied to polysaccharides-based hydrogels usually involves chemical analysis, tissue cultures, and animal tests [ 7 , 8 , 249 , 250 , 251 , 252 , 253 , 254 , 255 ]. However, risk-free drug delivery systems do not exist, so those tests aim to screen systems or materials with maximum benefits and minimum risks.…”

Section: Performance Of Seaweed Polysaccharide-based Hydrogelsmentioning

confidence: 99%

“…Tissue cultures refer to using isolated cells to assess the cytotoxicity of materials, including qualitative and quantitative cytotoxicity tests. Qualitative tests are comprised of the direct contact procedure, the agar diffusion assay, and the minimum essential medium (MEM) elution assay, among which, the direct contact method is extensively used to evaluate the cytotoxicity of polysaccharides-based hydrogels used in the biomedical field [ 7 , 251 , 252 ]. Quantitative cytotoxicity evaluation shows higher priority than qualitative tests for the screening [ 256 ].…”

Section: Performance Of Seaweed Polysaccharide-based Hydrogelsmentioning

confidence: 99%

Algal Polysaccharides-Based Hydrogels: Extraction, Synthesis, Characterization, and Applications

Lin

Jiao²,

Kermanshahi-pour

2022

Marine Drugs

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Hydrogels are three-dimensional crosslinked hydrophilic polymer networks with great potential in drug delivery, tissue engineering, wound dressing, agrochemicals application, food packaging, and cosmetics. However, conventional synthetic polymer hydrogels may be hazardous and have poor biocompatibility and biodegradability. Algal polysaccharides are abundant natural products with biocompatible and biodegradable properties. Polysaccharides and their derivatives also possess unique features such as physicochemical properties, hydrophilicity, mechanical strength, and tunable functionality. As such, algal polysaccharides have been widely exploited as building blocks in the fabrication of polysaccharide-based hydrogels through physical and/or chemical crosslinking. In this review, we discuss the extraction and characterization of polysaccharides derived from algae. This review focuses on recent advances in synthesis and applications of algal polysaccharides-based hydrogels. Additionally, we discuss the techno-economic analyses of chitosan and acrylic acid-based hydrogels, drawing attention to the importance of such analyses for hydrogels. Finally, the future prospects of algal polysaccharides-based hydrogels are outlined.

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“…Several researchers discovered new anticoagulant drugs using synthesis by modifying with certain grup added or from natural materials [6]. The new drugs were tested for anticoagulant activity through in vivo, in vitro, or in silico assays [7][8][9][10][11][12][13][14]. In silico is known to be able to reduce failures in laboratory experiments by screening potential candidates using computational design for further synthesis.…”

Section: ■ Introductionmentioning

confidence: 99%

A Deep Overview of Anticoagulant Drugs: Recent Synthesis and Their Activity Assay

Astuti,

Ibrahim,

Zulfikar

et al. 2024

Indones. J. Chem.

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During the unprecedented COVID-19 pandemic, anticoagulant drugs have emerged as a crucial component of treatment alongside antivirus medications. Patients with severe COVID-19 frequently have critical conditions marked by blood clot development, necessitating the administration of anticoagulants. This review aims to provide a comprehensive overview of various anticoagulant drugs, their synthesis methods, and assays employed to predict their anticoagulant activity. Notable anticoagulant categories frequently utilized include oral anticoagulants heparin, non-vitamin K antagonists, and vitamin K antagonists. In recent years, the development of new anticoagulants has seen a shift towards a multifaceted approach that combines in silico prediction with in vitro and in vivo assays. In silico prediction techniques play a pivotal role in the initial screening process. This integrated approach has yielded promising results, paving the way for the synthesis of novel anticoagulant candidates, as substantiated by a battery of in vitro, in vivo, and ex-vivo tests.

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Semi-synthesis of hybrid ulvan-kappa-carrabiose polysaccharides and evaluation of their cytotoxic and anticoagulant effects

Cited by 8 publications

References 44 publications

Polysaccharide-Based Transdermal Drug Delivery

Polysaccharide-Based Transdermal Drug Delivery

Algal Polysaccharides-Based Hydrogels: Extraction, Synthesis, Characterization, and Applications

A Deep Overview of Anticoagulant Drugs: Recent Synthesis and Their Activity Assay

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