Semi-IPN chitosan/polyvinylpyrrolidone microspheres and films: sustained release and property optimisation

Abstract

A set of chitosan-polyvinylpyrrolidone (CH-PVP) microspheres were prepared as semi-inter penetrating networks (semi-IPN) and loaded with 5-fluorouracil. In vitro release studies showed faster release for semi-IPN microspheres compared to pure CH samples, and the total release was achieved in about 20-30 days, depending on the composition. In vitro cell studies were achieved against human breast adenocarcinoma cell line cells where adsorption of cells on microspheres with a significant decrease in their number was obtained. Meanwhile, the CH-PVP films, which were prepared with the same compositions as in the microspheres, demonstrated an increase in strength from 66 to 118 MPa as the PVP content was decreased. It can be concluded that the prepared CH-PVP semi-IPN microspheres are novel promising carriers compared to pure CH microspheres since it becomes possible to adjust stability and hydrophilicity of the microspheres as well as the release rates of the drugs from the microspheres by changing the ratio of CH/PVP composition.

Poly(sebacic anhydride) nanocapsules as carriers: effects of preparation parameters on properties and release of doxorubicin

“…Advances in material science and nanotechnology have accelerated the synthesis and the design of novel systems. Polymers or polymeric composites are commonly preferred materials because of their versatility and economically availability (Ulubayram, 2005;Hasirci, 2007;Ozerkan, 2013;Falconi, 2014). The devices such as site-specific drug carrying vehicles can be prepared as nanoparticles, nanowires, nanocages, etc., to deliver different bioactive substances, such as antibiotics , peptides (Wang and Zhang, 2012;Tan, 2013), bone morphogenetic proteins (Yilgor, 2013), chemotherapeutic agents (Muvaffak et al, 2005;Zhao et al, 2013) or genes (Huang et al, 2005).…”

Coating of silver nanoparticles on polyurethane film surface by green chemistry approach and investigation of antibacterial activity against S. epidermidis

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Preparation and release kinetics of carboxymethyl chitosan/cellulose acetate microspheres as drug delivery system

“…Chitosan microspheres have been investigated widely as controlled release delivery systems for antigens, vaccines, phytoalexin, proteins, cells, vitamins, and drugs . Furthermore various chitosan composite microspheres have been prepared with different materials such as poly (vinyl alcohol), tripolyphosphate, alginate, poly(lactic‐ co ‐glycolic acid), polyvinylpyrrolidone, ethyl cellulose, and cellulose acetate . In addition, different administration routes of microspheres are studied to enhance the bioavailability of drugs including via intranasal, ocular, inhalable, subcutaneous, colonic, intra‐articular, and oral delivery …”