Semen quality pattern and age threshold: a retrospective cross-sectional study of 71,623 infertile men in China, between 2011 and 2017

Li, W. N.; Jia, Miaomiao; Peng, Yangqin; Ding, Rui; Fan, Liqing; Liu, G.

doi:10.1186/s12958-019-0551-2

Cited by 36 publications

(37 citation statements)

References 30 publications

(29 reference statements)

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“…5 Subjects with post-testicular causes of infertility often show oligo-or azoospermia when a partial or a complete obstruction is present, respectively, 5,6 low semen volume and pH when ejaculatory duct obstruction or seminal vesicle/s agenesis/abnormalities occur, 5 and TV, gonadotropin and T levels in the normal range. 5 Large previous studies performed on infertile men reported that, according to the World Health Organization (WHO), 7 oligozoospermia was detected in 10% 8 to 30% [9][10][11] of cases, asthenozoospermia in 30%, 9,11 teratozoospermia in 21% 8 to 49%, 9 and low semen volume in 11% 11 to 15%. 8,10 Severe male factor infertility has been reported in 20.4% of infertile men, 2 azoospermia in ~ 5% 2,9 to 11%, 12 and T deficiency in 10.1 12 to 25.6% 13 of cases.…”

Section: Introductionmentioning

confidence: 98%

The European Academy of Andrology (EAA) ultrasound study on healthy, fertile men: clinical, seminal and biochemical characteristics

et al. 2020

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Background Infertility affects 7%‐12% of men, and its etiology is unknown in half of cases. To fill this gap, use of the male genital tract color‐Doppler ultrasound (MGT‐CDUS) has progressively expanded. However, MGT‐CDUS still suffers from lack of standardization. Hence, the European Academy of Andrology (EAA) has promoted a multicenter study (“EAA ultrasound study”) to assess MGT‐CDUS characteristics of healthy, fertile men to obtain normative parameters. Objectives To report (a) the development and methodology of the “EAA ultrasound study,” (b) the clinical characteristics of the cohort of healthy, fertile men, and (c) the correlations of both fertility history and seminal features with clinical parameters. Methods A cohort of 248 healthy, fertile men (35.3 ± 5.9 years) was studied. All subjects were asked to undergo, within the same day, clinical, biochemical, and seminal evaluation and MGT‐CDUS before and after ejaculation. Results The clinical, seminal, and biochemical characteristics of the cohort have been reported here. The seminal characteristics were consistent with those reported by the WHO (2010) for the 50th and 5th centiles for fertile men. Normozoospermia was observed in 79.6% of men, while normal sperm vitality was present in almost the entire sample. Time to pregnancy (TTP) was 3.0[1.0‐6.0] months. TTP was negatively correlated with sperm vitality (Adj.r =−.310, P = .011), but not with other seminal, clinical, or biochemical parameters. Sperm vitality and normal morphology were positively associated with fT3 and fT4 levels, respectively (Adj.r = .244, P < .05 and Adj.r = .232, P = .002). Sperm concentration and total count were negatively associated with FSH levels and positively, along with progressive motility, with mean testis volume (TV). Mean TV was 20.4 ± 4.0 mL, and the lower reference values for right and left testes were 15.0 and 14.0 mL. Mean TV was negatively associated with gonadotropin levels and pulse pressure. Varicocoele was found in 33% of men. Conclusions The cohort studied confirms the WHO data for all semen parameters and represents a reference with which to assess MGT‐CDUS normative parameters.

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Section: Introductionmentioning

confidence: 98%

The European Academy of Andrology (EAA) ultrasound study on healthy, fertile men: clinical, seminal and biochemical characteristics

et al. 2020

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“…Inicia-se entre os 35 e 40 anos, estendendo-se aos 65 anos e caracteriza-se por um estado de hipoestrogenismo progressivo. O envelhecimento feminino pode afetar além da quantidade e qualidade dos oócitos, a função uterina, uma vez que o endométrio perderia sua capacidade de garantir a fixação e o crescimento embrionário (LORENZI;DANELON;SACILOTO, 2005;PESSANHA et al, 2015). Corroborando com estas observações a idade avançada (>35anos) foi o fator mais prevalente como causa de infertilidade entre as mulheres.…”

Section: Discussionunclassified

“…Nos últimos anos, tem se observado uma queda considerável na qualidade do esperma entre indivíduos saudáveis e jovens. A etiologia para as alterações observadas na avaliação microscópica do espermatozoide pode ser atribuída, principalmente, a insuficiência testicular primária, resultante de uma anormalidade congênita ou adquirida em ambos os testículos (HARRIS et al, 2011;DURAIRAJANAYAGAM, 2018;LI et al, 2019). Além disso, hábitos cotidianos como usar roupas justas e ficar muito tempo sentado podem afetar a temperatura dos testículos e causar alterações (DURAIRAJANAYAGAM, 2018;ILACQUA et al, 2018) Embora seja possível identificar os fatores que causam infertilidade em ambos os sexos, a prevalência de infertilidade varia consideravelmente com os diferentes critérios de avaliação diagnóstica e as diferenças regionais que ocorrem em toda extensão do território brasileiro (DENTILLO, 2012).…”

Section: Introductionunclassified

Perfil Dos Casais Inférteis Submetidos À Técnica De Reprodução Humana Assistida

Santos¹,

Fraga²,

Takenami³

2020

POBS

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O objetivo deste estudo foi caracterizar o perfil dos casais inférteis submetidos à técnica de reprodução humana assistida (RHA) no município de Salvador, Bahia. Trata-se de um estudo de caráter retrospectivo, observacional, baseado em dados secundários, obtidos mediante consulta aos prontuários eletrônicos dos pacientes cadastrados em uma clínica particular de RHA durante o ano de 2017. As variáveis categóricas e quantitativas foram apresentadas em valor absoluto e relativo, média ± desvio-padrão, respectivamente. Posteriormente, analisadas por meio de um software estatístico. Dos 496 pacientes atendidos na clínica de reprodução, 360 (72,6%) foram diagnosticados com infertilidade. A causa compartilhada (n=224; 62,2%) foi mais prevalente do que a isolada por sexo. Entre as mulheres, observa-se que a idade avançada (30,8%) e endometriose (26,5%) representam as principais causas de infertilidade. Nos homens, a teratozoospermia (36,9%) e a varicocele (33,6%) foram os fatores que mais comprometeram a fertilidade. A qualidade do gameta feminino e masculino é severamente comprometida em pacientes que tem como causa de infertilidade a falência ovariana (62,5%) e oligoastenoteratozoospermia (56,5%), respectivamente. No entanto, observa-se que nas mulheres, a baixa qualidade embrionária está mais associada à obstrução tubária (47,7%), enquanto que nos homens, o mesmo fator associado a baixa qualidade seminal é também responsável pelo desenvolvimento insatisfatório dos embriões (69,2%). Por fim, conclui-se que a infertilidade acomete, em maior proporção, homens e mulheres simultaneamente. Nas mulheres, a infertilidade associa-se a idade avançada e endometriose, enquanto que nos homens a teratozoospermia e varicocele. Essas causas, além de impactarem na qualidade dos gametas, também afetam a qualidade e desenvolvimento embrionário.

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“…In the late XX -early XXI centuries, the numerous population studies of sperm quality in men were performed in different regions of Europe, North America and Southeast Asia. These studies revealed regional and ethnic differences in sperm count, sperm motility and percentage of morphologically normal sperm [25][26][27][28][29][30] as well as decreasing semen quality during the last decades [31,32] and high frequency of sub-optimal sperm quality in men from general population [33]. It is believed that revealed regional and ethnic differences may be caused by the complex in uences of various environmental and lifestyle factors [34] as well as genetic features associated with ethnicity.…”

Section: Introductionmentioning

confidence: 99%

Ethnic Differences in Spermatozoa Morphological Defects Diversity Among Men From Eastern Siberia, Russia

Клещев

Осадчук

Шантанова

et al. 2020

Preprint

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Background.Sperm morphology defects are considered to indicate several spermiogenesis anomalies, resulting in decreased men fertility, causing not only poor sperm morphology but also increased DNA fragmentation, chromatin condensation defects, increased oxidative stress. Consequently, detailed assessment of sperm morphological abnormalities in additional to counting percentage of sperm with normal morphology may be useful for andrologists and reproductive biologists. However, a little attention is paid to studying a regional and especially ethnic variability in the incidence of the sperm morphology defects. The aim of this research was to estimate ethnic variability in percentages of the sperm morphology abnormalities in men from general population living in the Siberian region of the Russian Federation.Methods.Male volunteers of Buryat (n=195), Yakut (n=130), and Slavic (n=89) ethnicity from the general population from Ulan-Ude and Yakutsk at least 5 years were enrolled in the study. Percentages of sperm morphological defects (according to the classification provided by the WHO laboratory manual, 2010) are counted after staining native ejaculate smears by Diff-Quick kits. Results.Among sperm defect, amorphous (62.25±12.18%), elongated (10.61±8.62%), pyriform(8.61±9.17%), and vacuolated heads (10.31±6.77%), abnormal acrosome (20.43±12.67%), asymmetrical insertion neck (18.33±6,43%), thick midpiece (6.21±3,41%), bent head (5.94±4,02%) and coiled tail (10.8±6.79%) were most frequent. In comparison with Buryats, Slavs and Yakuts were characterized by the decreased proportion sperm with normal morphology, the increased proportion of pyriform, elongated heads, abnormal acrosome, asymmertical tail insertion, excessive residual cytoplasm and increased teratozoospermia index (TZI). It was shown that impared progressive sperm motility and concentration associated with decreased percentage of sperm with normal morphology and increased proportion most of sperm morphology defects and TZI. However, increasing TZI in men with oligoastenozoospermia compared to men with astenozoospermia was revealed for Buryats only, suggesting ethnic features in the relationships between sperm morphology and concentration.Conclusion.The present study showed significant coordinated ethnic variability in the percentages of several sperm morphological defects in men from the general population located in Eastern Siberia. Damaged spermiogenesis processes underlying sperm head elongation and tail formation is considered to be significant contributors to geographical and ethnic variability of sperm morphology in men from the studied populations.

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Semen quality pattern and age threshold: a retrospective cross-sectional study of 71,623 infertile men in China, between 2011 and 2017

Cited by 36 publications

References 30 publications

The European Academy of Andrology (EAA) ultrasound study on healthy, fertile men: clinical, seminal and biochemical characteristics

The European Academy of Andrology (EAA) ultrasound study on healthy, fertile men: clinical, seminal and biochemical characteristics

Perfil Dos Casais Inférteis Submetidos À Técnica De Reprodução Humana Assistida

Ethnic Differences in Spermatozoa Morphological Defects Diversity Among Men From Eastern Siberia, Russia

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