Semen quality and cigarette smoking in a cohort of healthy fertile men

Tang, Qiuqin; Pan, Feng; Wang, Xian; Nichols, C.E.; Wang, Xinru; Xia, Yankai; London, Stephanie J.; Wu, Wei

doi:10.1097/ee9.0000000000000055

Cited by 30 publications

(24 citation statements)

References 33 publications

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“…98 Evaluating socio-demographic characteristics, in this cohort current smokers were about one out of four men, mainly reporting a mild consumption. Previous studies on fertile men 14,21,[99][100][101] found relatively higher rates of current smokers than the present study. To date, considering previous studies 14,21,[99][100][101] In the present study, alcohol consumption was reported by one out of three men, mainly as a mild intake, and was associated with a lower sperm vitality compared to the rest of the sample.…”

Section: F I G U R Econtrasting

confidence: 80%

“…Previous studies on fertile men 14,21,[99][100][101] found relatively higher rates of current smokers than the present study. To date, considering previous studies 14,21,[99][100][101] In the present study, alcohol consumption was reported by one out of three men, mainly as a mild intake, and was associated with a lower sperm vitality compared to the rest of the sample. Previous meta-analyses showed that alcohol intake has a detrimental effect on semen volume 105,106 and normal sperm morphology.…”

Section: F I G U R Econtrasting

confidence: 80%

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The European Academy of Andrology (EAA) ultrasound study on healthy, fertile men: clinical, seminal and biochemical characteristics

et al. 2020

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Background Infertility affects 7%‐12% of men, and its etiology is unknown in half of cases. To fill this gap, use of the male genital tract color‐Doppler ultrasound (MGT‐CDUS) has progressively expanded. However, MGT‐CDUS still suffers from lack of standardization. Hence, the European Academy of Andrology (EAA) has promoted a multicenter study (“EAA ultrasound study”) to assess MGT‐CDUS characteristics of healthy, fertile men to obtain normative parameters. Objectives To report (a) the development and methodology of the “EAA ultrasound study,” (b) the clinical characteristics of the cohort of healthy, fertile men, and (c) the correlations of both fertility history and seminal features with clinical parameters. Methods A cohort of 248 healthy, fertile men (35.3 ± 5.9 years) was studied. All subjects were asked to undergo, within the same day, clinical, biochemical, and seminal evaluation and MGT‐CDUS before and after ejaculation. Results The clinical, seminal, and biochemical characteristics of the cohort have been reported here. The seminal characteristics were consistent with those reported by the WHO (2010) for the 50th and 5th centiles for fertile men. Normozoospermia was observed in 79.6% of men, while normal sperm vitality was present in almost the entire sample. Time to pregnancy (TTP) was 3.0[1.0‐6.0] months. TTP was negatively correlated with sperm vitality (Adj.r =−.310, P = .011), but not with other seminal, clinical, or biochemical parameters. Sperm vitality and normal morphology were positively associated with fT3 and fT4 levels, respectively (Adj.r = .244, P < .05 and Adj.r = .232, P = .002). Sperm concentration and total count were negatively associated with FSH levels and positively, along with progressive motility, with mean testis volume (TV). Mean TV was 20.4 ± 4.0 mL, and the lower reference values for right and left testes were 15.0 and 14.0 mL. Mean TV was negatively associated with gonadotropin levels and pulse pressure. Varicocoele was found in 33% of men. Conclusions The cohort studied confirms the WHO data for all semen parameters and represents a reference with which to assess MGT‐CDUS normative parameters.

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Section: F I G U R Econtrasting

confidence: 80%

Section: F I G U R Econtrasting

confidence: 80%

The European Academy of Andrology (EAA) ultrasound study on healthy, fertile men: clinical, seminal and biochemical characteristics

et al. 2020

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“…(1) Fertility Very common habits, like smoking or alcohol intake, could influence paternal sexual functions at different levels. Studies suggest a detrimental effect of tobacco smoking mediated by reduced sexual hormones levels and exposure of spermatozoa to oxidative stress [41,42]. Heavy smokers present lower sperm concentration, total count and more pronounced teratozoospermia which entail decreased ART success rates although effects on sperm motility are found unaffected [41,43].…”

Section: ) Lifestyle Paternal Factorsmentioning

confidence: 99%

“…Studies suggest a detrimental effect of tobacco smoking mediated by reduced sexual hormones levels and exposure of spermatozoa to oxidative stress [41,42]. Heavy smokers present lower sperm concentration, total count and more pronounced teratozoospermia which entail decreased ART success rates although effects on sperm motility are found unaffected [41,43]. In addition, smoking exposes to hazardous substances like tar, nicotine, carbon monoxide, and heavy metals (e.g., cadmium and lead) with implications for semen DNA integrity leading to aneuploidies and mutations [43].…”

Section: ) Lifestyle Paternal Factorsmentioning

confidence: 99%

“…In addition, smoking exposes to hazardous substances like tar, nicotine, carbon monoxide, and heavy metals (e.g., cadmium and lead) with implications for semen DNA integrity leading to aneuploidies and mutations [43]. It is somewhat reassuring that, following smoking cessation, a healing effect on semen quality has been observed [41].…”

Section: ) Lifestyle Paternal Factorsmentioning

confidence: 99%

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