Anything New about Paternal Contribution to Reproductive Outcomes? A Review of the Evidence

Montagnoli, Caterina; Ruggeri, Stefania; Cinelli, Giulia; Tozzi, Alberto Eugenio; Bovo, Chiara; Bortolus, Renata; Zanconato, Giovanni

doi:10.5534/wjmh.200147

Cited by 10 publications

(8 citation statements)

References 103 publications

(159 reference statements)

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“…In Japan, for instance, the implications of an MD or any related nutritional pattern upon IVF outcomes and clinical pregnancy rates remain undetermined [22]. Paternal nutrition also needs to be accounted for since substantial data suggest that a healthy diet can improve semen quality and fecundability rates [60].…”

Section: Discussionmentioning

confidence: 99%

Maternal periconceptional nutrition matters. A scoping review of the current literature

Montagnoli

Santoro

Buzzi

et al. 2021

The Journal of Maternal-Fetal & Neonatal Medicine

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Background: The importance of nutrition in reproductive health is widely acknowledged with special emphasis given to periconceptional maternal diet and its implications on embryo-fetal development, pregnancy complications, and the health of the offspring. Methods: Following the PRISMA guidelines, we searched for literature in PubMed, CINAHL, and WoS to gather newer information on how diet composition influences the concepts from the very early stages of pregnancy and how maternal health may be affected as well. Fifty-six studies published up to June 2020 met the inclusion criteria. Results: With its proportioned and diversified macronutrient composition, the Mediterranean Diet prevents congenital anomalies, preterm birth, hypertensive disorders, and gestational diabetes. Similar dietary patterns rich in vegetables, nuts, fish, and cereals increase the likelihood of conception and have a protective action, mediated by their antioxidant properties, against orofacial clefts, congenital heart and limb defects in the progeny. Conversely, the pro-inflammatory features of western diets, rich in processed foods and low in fruit content, diminish fertility, increase miscarriage rates, and enhance the risk of neural tube defects regardless of folate supplementation. Conclusions: It may be concluded that within the multiple dietary options, some of them are soundly associated with beneficial effects for the mother and the newborn. IMPLICATIONS FOR PRACTICEAn appropriate counseling must be offered to the woman of fertile age to make her aware of how periconceptional nutrition may help fulfill her reproductive expectations.

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Section: Discussionmentioning

confidence: 99%

Maternal periconceptional nutrition matters. A scoping review of the current literature

Montagnoli

Santoro

Buzzi

et al. 2021

The Journal of Maternal-Fetal & Neonatal Medicine

Self Cite

View full text Add to dashboard Cite

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“…This further highlights the imbalance of DOHaD research towards studies of maternal pregnancy exposures, which has been illustrated by other recent studies [ 4 , 5 ]. This review adds to research demonstrating the influence of paternal health and lifestyle on offspring health [ 6 , 7 , 17 ], and specifically the detrimental impact paternal behaviours around pregnancy may have on offspring mental health.…”

Section: Discussionmentioning

confidence: 99%

“…Negative control analyses are a method used to explore if associations are due to confounding or are likely to be causal [ 14 ], and are often the main reason why paternal exposures during pregnancy have been included in previous research [ 15 , 16 ]. A recent review distinguished between the impact of direct paternal biological and environmental effects, again highlighting the way paternal behaviour can impact offspring health [ 17 ]. This review was broad, focusing on outcomes of male fertility, early pregnancy complications as well as fetal and postnatal outcomes.…”

Section: Introductionmentioning

confidence: 99%

The impact of paternal alcohol, tobacco, caffeine use and physical activity on offspring mental health: a systematic review and meta-analysis

Easey

Sharp

2021

Reprod Health

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Background There is some evidence that paternal health behaviours during and around pregnancy could be associated with offspring health outcomes. However, the impact that paternal health behaviours during pregnancy can have on offspring mental health is understudied and remains unclear. Methods We conducted a systematic review and meta-analysis of articles in PubMed describing studies of potentially modifiable paternal health behaviours (tobacco smoking, alcohol consumption, caffeine consumption and physical activity) in the prenatal period in relation to offspring mental health. GRADE was used to measure risk of bias. Results Eight studies were included and categorized by paternal health behaviour and offspring mental health outcome investigated. The narrative synthesis provided evidence of association between paternal health behaviours around pregnancy and offspring mental health problems, with the strongest evidence shown for tobacco use. Grouped by analysis type, two separate meta-analyses showed evidence of paternal smoking during pregnancy being associated with greater odds of ADHD in offspring (OR 1.42, 95% CI 1.02–1.99; HR 1.28, 95% CI 1.19–1.39). Conclusions The small number of studies that have investigated paternal prenatal effects on offspring mental health, and the limited sample sizes of those studies, makes it challenging to draw firm conclusions. Although existing studies suggest that paternal tobacco smoking and alcohol consumption in the prenatal period are associated with poorer offspring mental health, (particularly hyperactivity/ADHD), further investigation of potential paternal effects is required, using methods that allow stronger inference to determine whether associations are causal.

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“…Most preconception health research disproportionately focuses on women with the greatest progress toward understanding the salience of men's preconception health made only in the past 10 years. These studies, which often focus on men's biological contributions to pregnancy, suggest that men's poor preconception health can impair fertility, and reduce semen quality and quantity (2)(3)(4)(5)(6)(7). Less is known about the social factors that contribute to men's preconception health or how these factors impact the aggregation of preconception health indicators at the population level.…”

Section: Introductionmentioning

confidence: 99%

Men's preconception health and the social determinants of health: What are we missing?

Anakwe¹,

Xian²,

BeLue³

et al. 2022

Front. Reprod. Health

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BackgroundLife course perspectives suggest that optimizing men's health before conception is requisite to equitably improve population health, an area of increasing public health focus. Although scholarship on the social determinants of health (SDOH) suggests that men's health and health behaviors do not occur in a vacuum, preconception health studies have not explicitly examined how these factors influence men's preconception health.ObjectiveTo identify latent classes of men's preconception health and the role of the SDOHs in predicting class membership.MethodsPooled data from the 2011–2019 male file of the National Survey of Family Growth were analyzed (n = 10,223). Latent class analysis (LCA) was used to identify distinct classes of men's preconception health. Eight manifest variables were used to fit latent class models. A classify-analyze approach was subsequently used to create a preconception health phenotype (PhP) outcome variable. SDOHs (exposure variable) were assessed in four domains (rural/urban residence, health access, socioeconomic status, and minority/immigrant status) to predict class membership. Survey-weighted multinomial regression models were fitted to examine the association between the exposure and the outcome.ResultsThree unique PhPs were identified (lowest risk (69%), substance users (22.9%), and sexual risk-takers (8.1%) from the LCA model. Health access, socioeconomic status, and minority/immigrant status were significant predictors of class membership but not rural/urban residence. Sexual risk takers were more likely to be uninsured (aOR: 1.25, 95% CI 1.02, 1.52), college-educated (aOR: 1.94 95% CI: 1.34, 2.79), and non-Hispanic Black (aOR: 1.99 95% CI: 1.55, 2.54) while substance users were more likely to have unstable employment (aOR: 1.23 95% CI:1.04, 1.45) and have a high school degree or higher (aOR 1.48 95% CI: 1.15, 1.90) than men in the lowest risk category.ConclusionSocial determinants may impact men's preconception health in ways that are not conventionally understood. These findings raise important questions about how preconception health interventions should be created, tailored, and/or retooled. Specifically, studies that examine the sociocultural and political contexts underpinning the relationship between social class, masculinity, and men's preconception health are needed to provide nuanced insights on factors that shape these outcomes.

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Anything New about Paternal Contribution to Reproductive Outcomes? A Review of the Evidence

Cited by 10 publications

References 103 publications

Maternal periconceptional nutrition matters. A scoping review of the current literature

Maternal periconceptional nutrition matters. A scoping review of the current literature

The impact of paternal alcohol, tobacco, caffeine use and physical activity on offspring mental health: a systematic review and meta-analysis

Men's preconception health and the social determinants of health: What are we missing?

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